DegronMD

Uniprot ID: Q8NEJ9

Source protein: Neuroguidin

Source gene: NGDN

Class: LIG_APCC_ABBA_1

Location: 177:182

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.99

ASA_SCORE: 87.2333

COIL: 0.8708

CONS_SCORE: 0.7968

DSS_SCORE: 0.4795

HELIX: 0.0857

FCONS_SCORE: 0.9936

RIG_SCORE: 0.7679

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V177F	TCGA-66-2791	LUSC	TCGA	VPVHYD	LIG_APCC_ABBA_1	0.5957
p.V177F	DO26435	LUSC	ICGC	VPVHYD	LIG_APCC_ABBA_1	0.5957
p.R188P	TCGA-67-3771	LUAD	TCGA	VPVHYD	LIG_APCC_ABBA_1	0.1667
p.R188P	DO25797	LUAD	ICGC	VPVHYD	LIG_APCC_ABBA_1	0.1667
p.R175H	TCGA-AJ-A3EL	UCEC	TCGA	VPVHYD	LIG_APCC_ABBA_1	0.2778
p.R175H	DO41542	UCEC	ICGC	VPVHYD	LIG_APCC_ABBA_1	0.2778
p.K169N	TCGA-B5-A1MR	UCEC	TCGA	VPVHYD	LIG_APCC_ABBA_1	0.2222
p.K169N	TCGA-EO-A22U	UCEC	TCGA	VPVHYD	LIG_APCC_ABBA_1	0.2222
p.K169N	TCGA-EO-A3B0	UCEC	TCGA	VPVHYD	LIG_APCC_ABBA_1	0.2222
p.K169N	DO219773	UCEC	ICGC	VPVHYD	LIG_APCC_ABBA_1	0.2222
p.K169N	DO41758	UCEC	ICGC	VPVHYD	LIG_APCC_ABBA_1	0.2222
p.K169N	DO43755	UCEC	ICGC	VPVHYD	LIG_APCC_ABBA_1	0.2222
p.H180Y	DO233764	GACA	ICGC	VPVHYD	LIG_APCC_ABBA_1	0.6118
p.E189D	DO228900	LICA	ICGC	VPVHYD	LIG_APCC_ABBA_1	0.1389
p.E189D	DO229019	LICA	ICGC	VPVHYD	LIG_APCC_ABBA_1	0.1389
p.V172F	DO229035	LICA	ICGC	VPVHYD	LIG_APCC_ABBA_1	0.1944
p.V167L	DO229038	LICA	ICGC	VPVHYD	LIG_APCC_ABBA_1	0.0556
p.D182Y	DO229037	LICA	ICGC	VPVHYD	LIG_APCC_ABBA_1	0.7325
p.V179I	SIDM00460	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPVHYD	LIG_APCC_ABBA_1	0.5965
p.V179I	ACH-000124	Lymphoma	CCLE	VPVHYD	LIG_APCC_ABBA_1	0.5965
p.V179I	OCI-LY-19	haematopoietic_and_lymphoid_tissue	COSMIC	VPVHYD	LIG_APCC_ABBA_1	0.5965
p.R175C	SIDM00596	Endometrial Carcinoma	GDSC	VPVHYD	LIG_APCC_ABBA_1	0.2778
p.R175C	ACH-001517	Endometrial/Uterine Cancer	CCLE	VPVHYD	LIG_APCC_ABBA_1	0.2778
p.R175C	HEC-1	endometrium	COSMIC	VPVHYD	LIG_APCC_ABBA_1	0.2778
p.E185Q	SIDM01645	Non-Cancerous	GDSC	VPVHYD	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEJ9	Neuroguidin	LIG_APCC_ABBA_1	177:182	VPVHYD	APC,CDC20,FZR1	0.99	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons