DegronMD

Uniprot ID: P10071

Source protein: Transcriptional activator GLI3

Source gene: GLI3

Class: DEG_SCF_FBW7_1

Location: 1538:1544

E3 ligase: FBXW7

DEGRON score: 0.8297

ASA_SCORE: 95.8571

COIL: 0.9129

CONS_SCORE: 0.3888

DSS_SCORE: 0.4281

HELIX: 0.0327

FCONS_SCORE: 1.08

RIG_SCORE: 0.6897

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1542L	TCGA-17-Z049	LUAD	TCGA	LTTPRAS	DEG_SCF_FBW7_1	0.7316
p.R1542W	TCGA-AZ-4615	COAD	TCGA	LTTPRAS	DEG_SCF_FBW7_1	0.7523
p.R1542W	DO7977	COAD	ICGC	LTTPRAS	DEG_SCF_FBW7_1	0.7523
p.R1542W	DO233737	GACA	ICGC	LTTPRAS	DEG_SCF_FBW7_1	0.7523
p.A1549V	TCGA-B5-A3FC	UCEC	TCGA	LTTPRAS	DEG_SCF_FBW7_1	0.1944
p.A1549V	TCGA-EI-6917	READ	TCGA	LTTPRAS	DEG_SCF_FBW7_1	0.1944
p.A1549V	DO36881	READ	ICGC	LTTPRAS	DEG_SCF_FBW7_1	0.1944
p.A1549V	DO41871	UCEC	ICGC	LTTPRAS	DEG_SCF_FBW7_1	0.1944
p.A1549V	SIDM00251	Gastric Carcinoma	GDSC	LTTPRAS	DEG_SCF_FBW7_1	0.1944
p.A1549V	ACH-000949	Gastric Cancer	CCLE	LTTPRAS	DEG_SCF_FBW7_1	0.1944
p.A1549V	TGBC11TKB	stomach	COSMIC	LTTPRAS	DEG_SCF_FBW7_1	0.1944
p.A1543G	TCGA-BK-A139	UCEC	TCGA	LTTPRAS	DEG_SCF_FBW7_1	0.6429
p.A1543G	DO41716	UCEC	ICGC	LTTPRAS	DEG_SCF_FBW7_1	0.6429
p.R1537H	TCGA-CM-6677	COAD	TCGA	LTTPRAS	DEG_SCF_FBW7_1	0.3056
p.R1537H	TCGA-DM-A0XD	COAD	TCGA	LTTPRAS	DEG_SCF_FBW7_1	0.3056
p.R1537H	TCGA-HU-8243	STAD	TCGA	LTTPRAS	DEG_SCF_FBW7_1	0.3056
p.R1537H	DO10228	COAD	ICGC	LTTPRAS	DEG_SCF_FBW7_1	0.3056
p.R1537H	DO8570	COAD	ICGC	LTTPRAS	DEG_SCF_FBW7_1	0.3056
p.R1537H	DO47915	STAD	ICGC	LTTPRAS	DEG_SCF_FBW7_1	0.3056
p.S1551C	TCGA-L5-A8NR	ESCA	TCGA	LTTPRAS	DEG_SCF_FBW7_1	0.1389
p.A1549E	TCGA-L9-A7SV	LUAD	TCGA	LTTPRAS	DEG_SCF_FBW7_1	0.1944
p.A1549E	DO49875	LUAD	ICGC	LTTPRAS	DEG_SCF_FBW7_1	0.1944
p.S1553G	TCGA-ND-A4WF	UCS	TCGA	LTTPRAS	DEG_SCF_FBW7_1	0.0833
p.T1540M	DO224768	BRCA	ICGC	LTTPRAS	DEG_SCF_FBW7_1	0.7423
p.T1540M	DO50398	ESAD	ICGC	LTTPRAS	DEG_SCF_FBW7_1	0.7423
p.T1540K	DO229035	LICA	ICGC	LTTPRAS	DEG_SCF_FBW7_1	0.7306
p.S1535F	DO232224	PBCA	ICGC	LTTPRAS	DEG_SCF_FBW7_1	0.25
p.S1535F	DO229479	SKCA	ICGC	LTTPRAS	DEG_SCF_FBW7_1	0.25
p.A1543T	DO229240	THCA	ICGC	LTTPRAS	DEG_SCF_FBW7_1	0.6028
p.L1545P	SIDM01662	Plasma Cell Myeloma	GDSC	LTTPRAS	DEG_SCF_FBW7_1	0.3056
p.L1545P	ACH-000564	Myeloma	CCLE	LTTPRAS	DEG_SCF_FBW7_1	0.3056
p.T1540A	ACH-000665	Lung Cancer	CCLE	LTTPRAS	DEG_SCF_FBW7_1	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTTPRAS

Degron related mutations and impact score

Drug responses associated with GLI3 mutations

All proteins holding degron of LTTPRAS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10071	Transcriptional activator GLI3	DEG_SCF_FBW7_1	1538:1544	LTTPRAS	FBXW7	0.8297	More...