DegronMD

Uniprot ID: P10071

Source protein: Transcriptional activator GLI3

Source gene: GLI3

Class: LIG_APCC_ABBA_1

Location: 197:202

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.797

ASA_SCORE: 55.6

COIL: 0.6693

CONS_SCORE: 0.3661

DSS_SCORE: 0.3824

HELIX: 0.2763

FCONS_SCORE: 0.844

RIG_SCORE: 0.7547

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I197T	TCGA-A5-A1OF	UCEC	TCGA	INPYMD	LIG_APCC_ABBA_1	0.7078
p.I197T	DO42568	UCEC	ICGC	INPYMD	LIG_APCC_ABBA_1	0.7078
p.R205H	TCGA-AA-A022	COAD	TCGA	INPYMD	LIG_APCC_ABBA_1	0.25
p.R205H	TCGA-AX-A2HD	UCEC	TCGA	INPYMD	LIG_APCC_ABBA_1	0.25
p.R205H	DO10647	COAD	ICGC	INPYMD	LIG_APCC_ABBA_1	0.25
p.R205H	DO42608	UCEC	ICGC	INPYMD	LIG_APCC_ABBA_1	0.25
p.F190I	TCGA-CC-A5UD	LIHC	TCGA	INPYMD	LIG_APCC_ABBA_1	0.1389
p.F190I	DO219552	LIHC	ICGC	INPYMD	LIG_APCC_ABBA_1	0.1389
p.P192H	TCGA-CM-6170	COAD	TCGA	INPYMD	LIG_APCC_ABBA_1	0.1944
p.P192H	DO7849	COAD	ICGC	INPYMD	LIG_APCC_ABBA_1	0.1944
p.P195L	TCGA-D3-A51R	SKCM	TCGA	INPYMD	LIG_APCC_ABBA_1	0.2778
p.P195L	DO49149	PACA	ICGC	INPYMD	LIG_APCC_ABBA_1	0.2778
p.P195L	DO47480	SKCM	ICGC	INPYMD	LIG_APCC_ABBA_1	0.2778
p.P199S	TCGA-FR-A8YC	SKCM	TCGA	INPYMD	LIG_APCC_ABBA_1	0.6752
p.P199S	DO50301	SKCM	ICGC	INPYMD	LIG_APCC_ABBA_1	0.6752
p.S209G	DO233624	GACA	ICGC	INPYMD	LIG_APCC_ABBA_1	0.1389
p.S188Y	DO228971	LICA	ICGC	INPYMD	LIG_APCC_ABBA_1	0.0833
p.S209R	DO229029	LICA	ICGC	INPYMD	LIG_APCC_ABBA_1	0.1389
p.S191R	DO229031	LICA	ICGC	INPYMD	LIG_APCC_ABBA_1	0.1667
p.R205C	DO34696	PACA	ICGC	INPYMD	LIG_APCC_ABBA_1	0.25
p.P199L	SIDM00007	Other Solid Cancers	GDSC	INPYMD	LIG_APCC_ABBA_1	0.6471
p.P199L	ACH-001550	Skin Cancer	CCLE	INPYMD	LIG_APCC_ABBA_1	0.6471
p.P199L	MCC13	skin	COSMIC	INPYMD	LIG_APCC_ABBA_1	0.6471
p.Y200C	SIDM00217	Colorectal Carcinoma	GDSC	INPYMD	LIG_APCC_ABBA_1	0.7087
p.Y200C	ACH-000999	Colon/Colorectal Cancer	CCLE	INPYMD	LIG_APCC_ABBA_1	0.7087
p.Y200C	SNU-1040	large_intestine	COSMIC	INPYMD	LIG_APCC_ABBA_1	0.7087
p.R189C	Sarc9371	bone	COSMIC	INPYMD	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10071	Transcriptional activator GLI3	LIG_APCC_ABBA_1	197:202	INPYMD	APC,CDC20,FZR1	0.797	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: INPYMD

Degron related mutations and impact score

Drug responses associated with GLI3 mutations

All proteins holding degron of INPYMD