DegronMD

Uniprot ID: P10071

Source protein: Transcriptional activator GLI3

Source gene: GLI3

Class: DEG_SPOP_SBC_1

Location: 34:38

E3 ligase: SPOP

DEGRON score: 0.9984

ASA_SCORE: 80.38

COIL: 0.8654

CONS_SCORE: 0.3772

DSS_SCORE: 0.6512

HELIX: 0.0278

FCONS_SCORE: 1.1129

RIG_SCORE: 0.6546

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S37N	TCGA-A5-A0G1	UCEC	TCGA	VASST	DEG_SPOP_SBC_1	0.7069
p.S37N	DO42472	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	0.7069
p.R26Q	TCGA-AJ-A5DW	UCEC	TCGA	VASST	DEG_SPOP_SBC_1	0.1111
p.R26Q	TCGA-BS-A0UV	UCEC	TCGA	VASST	DEG_SPOP_SBC_1	0.1111
p.R26Q	DO35128	PACA	ICGC	VASST	DEG_SPOP_SBC_1	0.1111
p.R26Q	DO50075	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	0.1111
p.R26Q	DO42793	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	0.1111
p.S36F	TCGA-AP-A051	UCEC	TCGA	VASST	DEG_SPOP_SBC_1	0.7982
p.S36F	DO42673	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	0.7982
p.D28N	TCGA-AP-A1DV	UCEC	TCGA	VASST	DEG_SPOP_SBC_1	0.1667
p.D28N	DO43186	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	0.1667
p.D28A	TCGA-D1-A17Q	UCEC	TCGA	VASST	DEG_SPOP_SBC_1	0.1667
p.D28A	DO41903	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	0.1667
p.S24Y	DO229019	LICA	ICGC	VASST	DEG_SPOP_SBC_1	0.0556
p.D43N	DO230990	LUSC	ICGC	VASST	DEG_SPOP_SBC_1	0.1944
p.D43N	DO224554	LUSC	ICGC	VASST	DEG_SPOP_SBC_1	0.1944
p.S45G	DO228600	MALY	ICGC	VASST	DEG_SPOP_SBC_1	0.5833
p.A47D	DO42673	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	0.0833
p.G47V	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	0.0833
p.G47V	ACH-000945	Lung Cancer	CCLE	VASST	DEG_SPOP_SBC_1	0.0833
p.G47V	NCI-H650	lung	COSMIC	VASST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94876	Transmembrane and coiled-coil domains protein 1	DEG_SPOP_SBC_1	208:212	VASST	SPOP	0.6543	More...
P10071	Transcriptional activator GLI3	DEG_SPOP_SBC_1	34:38	VASST	SPOP	0.9984	More...
P22670	MHC class II regulatory factor RFX1	DEG_SPOP_SBC_1	366:370	VASST	SPOP	0.601	More...
P35789	Zinc finger protein 93	DEG_SPOP_SBC_1	435:439	VASST	SPOP	0.6657	More...
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	444:448	VASST	SPOP	0.937	More...
Q14008	Cytoskeleton-associated protein 5	DEG_SPOP_SBC_1	1971:1975	VASST	SPOP	0.9917	More...
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_SPOP_SBC_1	860:864	VASST	SPOP	0.9989	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SPOP_SBC_1	110:114	VASST	SPOP	0.9912	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	862:866	VASST	SPOP	0.9864	More...
Q9H4H8	Protein FAM83D	DEG_SPOP_SBC_1	487:491	VASST	SPOP	0.9868	More...
Q9UHD8	Septin-9	DEG_SPOP_SBC_1	56:60	VASST	SPOP	0.9944	More...
Q9UI36	Dachshund homolog 1	DEG_SPOP_SBC_1	128:132	VASST	SPOP	0.9985	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	2007:2011	VASST	SPOP	0.9246	More...
Q9Y4G8	Rap guanine nucleotide exchange factor 2	DEG_SPOP_SBC_1	1380:1384	VASST	SPOP	0.9098	More...
Q8NCQ7	Protein PROCA1	DEG_SPOP_SBC_1	46:50	VASST	SPOP	0.8048	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons