DegronMD - Q14008(CKAP5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1974F	TCGA-90-A4ED	LUSC	TCGA	VASST	DEG_SPOP_SBC_1	1971:1975	Mutation altering degron motif	0.7982
p.C1911Y	TCGA-A5-A0G2	UCEC	TCGA	VPTPTST	DEG_SCF_FBW7_1	1912:1918	Mutation rewiring degron network	0.3056
p.R1525W	TCGA-A5-A0G2	UCEC	TCGA	VSPHFD	LIG_APCC_ABBA_1	1527:1532	Mutation rewiring degron network	0.2778
p.R1525W	TCGA-A5-A0VP	UCEC	TCGA	VSPHFD	LIG_APCC_ABBA_1	1527:1532	Mutation rewiring degron network	0.2778
p.R1525W	DO42600	UCEC	ICGC	VSPHFD	LIG_APCC_ABBA_1	1527:1532	Mutation rewiring degron network	0.2778
p.R1525W	DO41235	UCEC	ICGC	VSPHFD	LIG_APCC_ABBA_1	1527:1532	Mutation rewiring degron network	0.2778
p.S2005P	TCGA-AJ-A3OL	UCEC	TCGA	VTSSS	DEG_SPOP_SBC_1	2008:2012	Mutation rewiring degron network	0.25
p.P1913A	TCGA-AN-A0FL	BRCA	TCGA	VPTPTST	DEG_SCF_FBW7_1	1912:1918	Mutation altering degron motif	0.6392
p.I2017V	TCGA-B5-A3FA	UCEC	TCGA	VTSSS	DEG_SPOP_SBC_1	2008:2012	Mutation rewiring degron network	0.1944
p.T1975I	TCGA-CK-4951	COAD	TCGA	VASST	DEG_SPOP_SBC_1	1971:1975	Mutation altering degron motif	0.7078
p.S1973Y	TCGA-CK-4951	COAD	TCGA	VASST	DEG_SPOP_SBC_1	1971:1975	Mutation altering degron motif	0.712
p.P1969S	TCGA-DA-A3F8	SKCM	TCGA	TSLLSKPAVPTV	DEG_COP1_1	1960:1971	Mutation altering degron motif	0.6752
p.R1956Q	TCGA-DK-A6AW	BLCA	TCGA	DRPPLTSLL	DEG_APCC_DBOX_1	1955:1963	Mutation altering degron motif	0.7329
p.P1520S	TCGA-ER-A19O	SKCM	TCGA	VSPHFD	LIG_APCC_ABBA_1	1527:1532	Mutation rewiring degron network	0.1389
p.P1520S	DO38063	SKCM	ICGC	VSPHFD	LIG_APCC_ABBA_1	1527:1532	Mutation rewiring degron network	0.1389
p.L2020F	TCGA-HD-7229	HNSC	TCGA	VTSSS	DEG_SPOP_SBC_1	2008:2012	Mutation rewiring degron network	0.1111
p.S1945L	DO48457	BLCA	ICGC	DRPPLTSLL	DEG_APCC_DBOX_1	1955:1963	Mutation rewiring degron network	0.0556
p.S1923C	DO48449	BLCA	ICGC	VPTPTST	DEG_SCF_FBW7_1	1912:1918	Mutation rewiring degron network	0.1944
p.T1915I	DO10582	COAD	ICGC	VPTPTST	DEG_SCF_FBW7_1	1912:1918	Mutation altering degron motif	0.7078
p.S1913Y	DO10582	COAD	ICGC	VPTPTST	DEG_SCF_FBW7_1	1912:1918	Mutation altering degron motif	0.712
p.S1969N	DO233935	GACA	ICGC	TSLLSKPAVPTV	DEG_COP1_1	1960:1971	Mutation altering degron motif	0.7069
p.L1960F	DO15479	HNSC	ICGC	DRPPLTSLL	DEG_APCC_DBOX_1	1955:1963	Mutation altering degron motif	0.6981
p.L1960F	DO15479	HNSC	ICGC	TSLLSKPAVPTV	DEG_COP1_1	1960:1971	Mutation altering degron motif	0.6981
p.T1541K	DO229006	LICA	ICGC	VSPHFD	LIG_APCC_ABBA_1	1527:1532	Mutation rewiring degron network	0.0833
p.I1542V	DO231620	LINC	ICGC	VSPHFD	LIG_APCC_ABBA_1	1527:1532	Mutation rewiring degron network	0.0556
p.S1914F	DO45482	LUSC	ICGC	VPTPTST	DEG_SCF_FBW7_1	1912:1918	Mutation altering degron motif	0.7982
p.P1909S	DO37418	SKCM	ICGC	VPTPTST	DEG_SCF_FBW7_1	1912:1918	Mutation rewiring degron network	0.25
p.S1945P	DO43001	UCEC	ICGC	DRPPLTSLL	DEG_APCC_DBOX_1	1955:1963	Mutation rewiring degron network	0.0556
p.I1957V	DO52402	UCEC	ICGC	DRPPLTSLL	DEG_APCC_DBOX_1	1955:1963	Mutation altering degron motif	0.7076
p.E1965D	DO41235	UCEC	ICGC	TSLLSKPAVPTV	DEG_COP1_1	1960:1971	Mutation altering degron motif	0.6758
p.R1971C	DO43755	UCEC	ICGC	TSLLSKPAVPTV	DEG_COP1_1	1960:1971	Mutation altering degron motif	0.8301
p.R1971C	DO43755	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	1971:1975	Mutation altering degron motif	0.8301
p.R1971C	HT-115	large intestine	COSMIC	TSLLSKPAVPTV	DEG_COP1_1	1960:1971	Mutation altering degron motif	0.8301
p.R1971C	HT-115	large intestine	COSMIC	VASST	DEG_SPOP_SBC_1	1971:1975	Mutation altering degron motif	0.8301
p.P1905S	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VPTPTST	DEG_SCF_FBW7_1	1912:1918	Mutation rewiring degron network	0.1389
p.P1905S	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VPTPTST	DEG_SCF_FBW7_1	1912:1918	Mutation rewiring degron network	0.1389
p.P1905S	ACH-000995	Leukemia	CCLE	VPTPTST	DEG_SCF_FBW7_1	1912:1918	Mutation rewiring degron network	0.1389
p.P1905S	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VPTPTST	DEG_SCF_FBW7_1	1912:1918	Mutation rewiring degron network	0.1389
p.H2003D	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	VTSSS	DEG_SPOP_SBC_1	2008:2012	Mutation rewiring degron network	0.1944
p.H2003D	ACH-002272	Lymphoma	CCLE	VTSSS	DEG_SPOP_SBC_1	2008:2012	Mutation rewiring degron network	0.1944
p.H2003D	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	VTSSS	DEG_SPOP_SBC_1	2008:2012	Mutation rewiring degron network	0.1944
p.I1922L	SIDM00845	Burkitt's Lymphoma	GDSC	VPTPTST	DEG_SCF_FBW7_1	1912:1918	Mutation rewiring degron network	0.2222
p.I1922L	SIDM01519	Head and Neck Carcinoma	GDSC	VPTPTST	DEG_SCF_FBW7_1	1912:1918	Mutation rewiring degron network	0.2222
p.I1922L	ACH-000786	Lymphoma	CCLE	VPTPTST	DEG_SCF_FBW7_1	1912:1918	Mutation rewiring degron network	0.2222
p.D1532N	SIDM00860	Head and Neck Carcinoma	GDSC	VSPHFD	LIG_APCC_ABBA_1	1527:1532	Mutation altering degron motif	0.6932
p.D1532N	FADU	upper aerodigestive tract	COSMIC	VSPHFD	LIG_APCC_ABBA_1	1527:1532	Mutation altering degron motif	0.6932
p.D2019N	SIDM00534	Colorectal Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	2008:2012	Mutation rewiring degron network	0.1389
p.D2019N	ACH-000986	Colon/Colorectal Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	2008:2012	Mutation rewiring degron network	0.1389
p.D2019N	HT-115	large intestine	COSMIC	VTSSS	DEG_SPOP_SBC_1	2008:2012	Mutation rewiring degron network	0.1389
p.P1969H	ACH-000816	Lung Cancer	CCLE	TSLLSKPAVPTV	DEG_COP1_1	1960:1971	Mutation altering degron motif	0.7694
p.T1541A	ACH-001991	Primary	CCLE	VSPHFD	LIG_APCC_ABBA_1	1527:1532	Mutation rewiring degron network	0.0833
p.S1528Y	ACH-001991	Primary	CCLE	VSPHFD	LIG_APCC_ABBA_1	1527:1532	Mutation altering degron motif	0.712
p.D1959N	HT-115	large intestine	COSMIC	DRPPLTSLL	DEG_APCC_DBOX_1	1955:1963	Mutation altering degron motif	0.6932

Kaplan plot for CKAP5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CKAP5

UniProt ID: Q14008

Entrez ID: 9793

Protein name: Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CKAP5 in