DegronMD

Uniprot ID: Q14008

Source protein: Cytoskeleton-associated protein 5

Source gene: CKAP5

Class: LIG_APCC_ABBA_1

Location: 1527:1532

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9745

ASA_SCORE: 71.0167

COIL: 0.785

CONS_SCORE: 0.2312

DSS_SCORE: 0.4323

HELIX: 0.1322

FCONS_SCORE: 0.9675

RIG_SCORE: 0.7411

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1525W	TCGA-A5-A0G2	UCEC	TCGA	VSPHFD	LIG_APCC_ABBA_1	0.2778
p.R1525W	TCGA-A5-A0VP	UCEC	TCGA	VSPHFD	LIG_APCC_ABBA_1	0.2778
p.R1525W	DO42600	UCEC	ICGC	VSPHFD	LIG_APCC_ABBA_1	0.2778
p.R1525W	DO41235	UCEC	ICGC	VSPHFD	LIG_APCC_ABBA_1	0.2778
p.P1520S	TCGA-ER-A19O	SKCM	TCGA	VSPHFD	LIG_APCC_ABBA_1	0.1389
p.P1520S	DO38063	SKCM	ICGC	VSPHFD	LIG_APCC_ABBA_1	0.1389
p.T1541K	DO229006	LICA	ICGC	VSPHFD	LIG_APCC_ABBA_1	0.0833
p.I1542V	DO231620	LINC	ICGC	VSPHFD	LIG_APCC_ABBA_1	0.0556
p.D1532N	SIDM00860	Head and Neck Carcinoma	GDSC	VSPHFD	LIG_APCC_ABBA_1	0.6932
p.D1532N	FADU	upper_aerodigestive_tract	COSMIC	VSPHFD	LIG_APCC_ABBA_1	0.6932
p.T1541A	ACH-001991	Primary	CCLE	VSPHFD	LIG_APCC_ABBA_1	0.0833
p.S1528Y	ACH-001991	Primary	CCLE	VSPHFD	LIG_APCC_ABBA_1	0.712

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14008	Cytoskeleton-associated protein 5	LIG_APCC_ABBA_1	1527:1532	VSPHFD	APC,CDC20,FZR1	0.9745	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons