DegronMD

Uniprot ID: Q14008

Source protein: Cytoskeleton-associated protein 5

Source gene: CKAP5

Class: DEG_COP1_1

Location: 1960:1971

E3 ligase: COP1

DEGRON score: 0.9542

ASA_SCORE: 88.7083

COIL: 0.8701

CONS_SCORE: 0.2381

DSS_SCORE: 0.5662

HELIX: 0.1014

FCONS_SCORE: 0.9883

RIG_SCORE: 0.6872

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1969S	TCGA-DA-A3F8	SKCM	TCGA	TSLLSKPAVPTV	DEG_COP1_1	0.6752
p.S1969N	DO233935	GACA	ICGC	TSLLSKPAVPTV	DEG_COP1_1	0.7069
p.L1960F	DO15479	HNSC	ICGC	TSLLSKPAVPTV	DEG_COP1_1	0.6981
p.E1965D	DO41235	UCEC	ICGC	TSLLSKPAVPTV	DEG_COP1_1	0.6758
p.R1971C	DO43755	UCEC	ICGC	TSLLSKPAVPTV	DEG_COP1_1	0.8301
p.R1971C	HT-115	large_intestine	COSMIC	TSLLSKPAVPTV	DEG_COP1_1	0.8301
p.P1969H	ACH-000816	Lung Cancer	CCLE	TSLLSKPAVPTV	DEG_COP1_1	0.7694

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14008	Cytoskeleton-associated protein 5	DEG_COP1_1	1960:1971	TSLLSKPAVPTV	COP1	0.9542	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons