DegronMD

Uniprot ID: Q14008

Source protein: Cytoskeleton-associated protein 5

Source gene: CKAP5

Class: DEG_APCC_DBOX_1

Location: 1955:1963

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9925

ASA_SCORE: 91.0889

COIL: 0.8516

CONS_SCORE: 0.2248

DSS_SCORE: 0.591

HELIX: 0.1292

FCONS_SCORE: 0.8933

RIG_SCORE: 0.7167

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1956Q	TCGA-DK-A6AW	BLCA	TCGA	DRPPLTSLL	DEG_APCC_DBOX_1	0.7329
p.S1945L	DO48457	BLCA	ICGC	DRPPLTSLL	DEG_APCC_DBOX_1	0.0556
p.L1960F	DO15479	HNSC	ICGC	DRPPLTSLL	DEG_APCC_DBOX_1	0.6981
p.S1945P	DO43001	UCEC	ICGC	DRPPLTSLL	DEG_APCC_DBOX_1	0.0556
p.I1957V	DO52402	UCEC	ICGC	DRPPLTSLL	DEG_APCC_DBOX_1	0.7076
p.D1959N	HT-115	large_intestine	COSMIC	DRPPLTSLL	DEG_APCC_DBOX_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14008	Cytoskeleton-associated protein 5	DEG_APCC_DBOX_1	1955:1963	DRPPLTSLL	APC,CDC20,FZR1	0.9925	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons