DegronMD

Uniprot ID: Q14008

Source protein: Cytoskeleton-associated protein 5

Source gene: CKAP5

Class: DEG_SCF_FBW7_1

Location: 1912:1918

E3 ligase: FBXW7

DEGRON score: 0.9887

ASA_SCORE: 90.6286

COIL: 0.959

CONS_SCORE: 0.2394

DSS_SCORE: 0.5243

HELIX: 0.02

FCONS_SCORE: 1.0411

RIG_SCORE: 0.7278

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C1911Y	TCGA-A5-A0G2	UCEC	TCGA	VPTPTST	DEG_SCF_FBW7_1	0.3056
p.P1913A	TCGA-AN-A0FL	BRCA	TCGA	VPTPTST	DEG_SCF_FBW7_1	0.6392
p.S1923C	DO48449	BLCA	ICGC	VPTPTST	DEG_SCF_FBW7_1	0.1944
p.T1915I	DO10582	COAD	ICGC	VPTPTST	DEG_SCF_FBW7_1	0.7078
p.S1913Y	DO10582	COAD	ICGC	VPTPTST	DEG_SCF_FBW7_1	0.712
p.S1914F	DO45482	LUSC	ICGC	VPTPTST	DEG_SCF_FBW7_1	0.7982
p.P1909S	DO37418	SKCM	ICGC	VPTPTST	DEG_SCF_FBW7_1	0.25
p.P1905S	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VPTPTST	DEG_SCF_FBW7_1	0.1389
p.P1905S	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VPTPTST	DEG_SCF_FBW7_1	0.1389
p.P1905S	ACH-000995	Leukemia	CCLE	VPTPTST	DEG_SCF_FBW7_1	0.1389
p.P1905S	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	VPTPTST	DEG_SCF_FBW7_1	0.1389
p.I1922L	SIDM00845	Burkitt's Lymphoma	GDSC	VPTPTST	DEG_SCF_FBW7_1	0.2222
p.I1922L	SIDM01519	Head and Neck Carcinoma	GDSC	VPTPTST	DEG_SCF_FBW7_1	0.2222
p.I1922L	ACH-000786	Lymphoma	CCLE	VPTPTST	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14008	Cytoskeleton-associated protein 5	DEG_SCF_FBW7_1	1912:1918	VPTPTST	FBXW7	0.9887	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons