DegronMD

Uniprot ID: Q96F05

Source protein: Uncharacterized protein C11orf24

Source gene: C11orf24

Class: DEG_SPOP_SBC_1

Location: 110:114

E3 ligase: SPOP

DEGRON score: 0.9912

ASA_SCORE: 88.64

COIL: 0.9276

CONS_SCORE: 0.4179

DSS_SCORE: 0.3385

HELIX: 0.0324

FCONS_SCORE: 1.4994

RIG_SCORE: 0.7437

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A111V	TCGA-12-0778	GBM	TCGA	VASST	DEG_SPOP_SBC_1	0.5825
p.A111V	DO11411	GBM	ICGC	VASST	DEG_SPOP_SBC_1	0.5825
p.A111S	TCGA-55-6970	LUAD	TCGA	VASST	DEG_SPOP_SBC_1	0.6477
p.A111S	DO24421	LUAD	ICGC	VASST	DEG_SPOP_SBC_1	0.6477
p.A116V	TCGA-AD-A5EJ	COAD	TCGA	VASST	DEG_SPOP_SBC_1	0.2778
p.A116V	TCGA-XF-A9T8	BLCA	TCGA	VASST	DEG_SPOP_SBC_1	0.2778
p.A116V	DO51927	BLCA	ICGC	VASST	DEG_SPOP_SBC_1	0.2778
p.A116V	DO50090	COAD	ICGC	VASST	DEG_SPOP_SBC_1	0.2778
p.A122V	DO227987	COCA	ICGC	VASST	DEG_SPOP_SBC_1	0.1111
p.A122V	SIDM01619	Endometrial Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	0.1111
p.A117V	DO233941	GACA	ICGC	VASST	DEG_SPOP_SBC_1	0.25
p.A106D	DO229037	LICA	ICGC	VASST	DEG_SPOP_SBC_1	0.2222
p.S113I	DO50672	ORCA	ICGC	VASST	DEG_SPOP_SBC_1	0.7341
p.S113I	SIDM00251	Gastric Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	0.7341
p.S113I	ACH-000949	Gastric Cancer	CCLE	VASST	DEG_SPOP_SBC_1	0.7341
p.T103I	SIDM01090	Colorectal Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	0.1389
p.T103I	ACH-000943	Colon/Colorectal Cancer	CCLE	VASST	DEG_SPOP_SBC_1	0.1389
p.D100H	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	0.0556
p.D100H	ACH-000892	Lung Cancer	CCLE	VASST	DEG_SPOP_SBC_1	0.0556
p.I119S	SIDM01060	Melanoma	GDSC	VASST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94876	Transmembrane and coiled-coil domains protein 1	DEG_SPOP_SBC_1	208:212	VASST	SPOP	0.6543	More...
P10071	Transcriptional activator GLI3	DEG_SPOP_SBC_1	34:38	VASST	SPOP	0.9984	More...
P22670	MHC class II regulatory factor RFX1	DEG_SPOP_SBC_1	366:370	VASST	SPOP	0.601	More...
P35789	Zinc finger protein 93	DEG_SPOP_SBC_1	435:439	VASST	SPOP	0.6657	More...
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	444:448	VASST	SPOP	0.937	More...
Q14008	Cytoskeleton-associated protein 5	DEG_SPOP_SBC_1	1971:1975	VASST	SPOP	0.9917	More...
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_SPOP_SBC_1	860:864	VASST	SPOP	0.9989	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SPOP_SBC_1	110:114	VASST	SPOP	0.9912	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	862:866	VASST	SPOP	0.9864	More...
Q9H4H8	Protein FAM83D	DEG_SPOP_SBC_1	487:491	VASST	SPOP	0.9868	More...
Q9UHD8	Septin-9	DEG_SPOP_SBC_1	56:60	VASST	SPOP	0.9944	More...
Q9UI36	Dachshund homolog 1	DEG_SPOP_SBC_1	128:132	VASST	SPOP	0.9985	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	2007:2011	VASST	SPOP	0.9246	More...
Q9Y4G8	Rap guanine nucleotide exchange factor 2	DEG_SPOP_SBC_1	1380:1384	VASST	SPOP	0.9098	More...
Q8NCQ7	Protein PROCA1	DEG_SPOP_SBC_1	46:50	VASST	SPOP	0.8048	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons