DegronMD

Uniprot ID: P10071

Source protein: Transcriptional activator GLI3

Source gene: GLI3

Class: DEG_APCC_DBOX_1

Location: 829:837

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9203

ASA_SCORE: 72.5111

COIL: 0.8119

CONS_SCORE: 0.387

DSS_SCORE: 0.3838

HELIX: 0.0899

FCONS_SCORE: 1.017

RIG_SCORE: 0.7482

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L833I	TCGA-BS-A0UV	UCEC	TCGA	GRSDLSGVD	DEG_APCC_DBOX_1	0.7174
p.L833I	DO42793	UCEC	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	0.7174
p.S834F	TCGA-D3-A2JP	SKCM	TCGA	GRSDLSGVD	DEG_APCC_DBOX_1	0.6871
p.S834F	DO47407	SKCM	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	0.6871
p.L826F	TCGA-D3-A8GM	SKCM	TCGA	GRSDLSGVD	DEG_APCC_DBOX_1	0.25
p.L826F	DO50288	SKCM	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	0.25
p.T825M	TCGA-D5-6926	COAD	TCGA	GRSDLSGVD	DEG_APCC_DBOX_1	0.2222
p.T825M	DO8530	COAD	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	0.2222
p.T825M	DO234239	ESAD	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	0.2222
p.L827I	TCGA-D7-A4Z0	STAD	TCGA	GRSDLSGVD	DEG_APCC_DBOX_1	0.2778
p.L827I	DO47765	STAD	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	0.2778
p.G829D	TCGA-F1-6874	STAD	TCGA	GRSDLSGVD	DEG_APCC_DBOX_1	0.6087
p.G829D	DO38201	STAD	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	0.6087
p.P828L	TCGA-HF-7132	STAD	TCGA	GRSDLSGVD	DEG_APCC_DBOX_1	0.3056
p.P828L	DO38214	STAD	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	0.3056
p.D832N	DO227985	COCA	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	0.5821
p.T839N	DO228971	LICA	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	0.2778
p.D837E	DO229026	LICA	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	0.5647
p.T825K	DO229038	LICA	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	0.2222
p.P828Q	DO222731	MELA	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	0.3056
p.M840T	DO224575	PACA	ICGC	GRSDLSGVD	DEG_APCC_DBOX_1	0.25
p.N842D	SIDM00359	Colorectal Carcinoma	GDSC	GRSDLSGVD	DEG_APCC_DBOX_1	0.1944
p.N842D	ACH-000565	Colon/Colorectal Cancer	CCLE	GRSDLSGVD	DEG_APCC_DBOX_1	0.1944
p.N842D	RCM-1	large_intestine	COSMIC	GRSDLSGVD	DEG_APCC_DBOX_1	0.1944
p.V838I	SIDM01588	Endometrial Carcinoma	GDSC	GRSDLSGVD	DEG_APCC_DBOX_1	0.3056
p.V838I	ACH-000993	Endometrial/Uterine Cancer	CCLE	GRSDLSGVD	DEG_APCC_DBOX_1	0.3056
p.L833F	ACH-001389	Breast Cancer	CCLE	GRSDLSGVD	DEG_APCC_DBOX_1	0.6981
p.P827L	GP5d	large_intestine	COSMIC	GRSDLSGVD	DEG_APCC_DBOX_1	0.2778
p.R845H	MES-SA	soft_tissue	COSMIC	GRSDLSGVD	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRSDLSGVD

Degron related mutations and impact score

Drug responses associated with GLI3 mutations

All proteins holding degron of GRSDLSGVD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10071	Transcriptional activator GLI3	DEG_APCC_DBOX_1	829:837	GRSDLSGVD	APC,CDC20,FZR1	0.9203	More...