DegronMD

Uniprot ID: P10071

Source protein: Transcriptional activator GLI3

Source gene: GLI3

Class: DEG_SCF_TRCP1_1

Location: 655:660

E3 ligase: BTRC

DEGRON score: 0.9789

ASA_SCORE: 81.2833

COIL: 0.9062

CONS_SCORE: 0.3894

DSS_SCORE: 0.9626

HELIX: 0.069

FCONS_SCORE: 0.9912

RIG_SCORE: 0.4416

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q670E	TCGA-13-0893	OV	TCGA	DSGSHS	DEG_SCF_TRCP1_1	0.0556
p.Q670E	DO29002	OV	ICGC	DSGSHS	DEG_SCF_TRCP1_1	0.0556
p.Q661H	TCGA-35-3615	LUAD	TCGA	DSGSHS	DEG_SCF_TRCP1_1	0.3056
p.Q661H	DO23627	LUAD	ICGC	DSGSHS	DEG_SCF_TRCP1_1	0.3056
p.P653L	TCGA-37-4130	LUSC	TCGA	DSGSHS	DEG_SCF_TRCP1_1	0.2778
p.P653L	TCGA-BS-A0TJ	UCEC	TCGA	DSGSHS	DEG_SCF_TRCP1_1	0.2778
p.P653L	TCGA-F1-6874	STAD	TCGA	DSGSHS	DEG_SCF_TRCP1_1	0.2778
p.P653L	DO234335	ESAD	ICGC	DSGSHS	DEG_SCF_TRCP1_1	0.2778
p.P653L	DO26490	LUSC	ICGC	DSGSHS	DEG_SCF_TRCP1_1	0.2778
p.P653L	DO38201	STAD	ICGC	DSGSHS	DEG_SCF_TRCP1_1	0.2778
p.P653L	DO42953	UCEC	ICGC	DSGSHS	DEG_SCF_TRCP1_1	0.2778
p.P653L	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	DSGSHS	DEG_SCF_TRCP1_1	0.2778
p.P653L	ACH-000916	Lung Cancer	CCLE	DSGSHS	DEG_SCF_TRCP1_1	0.2778
p.P653L	NCI-H1573	lung	COSMIC	DSGSHS	DEG_SCF_TRCP1_1	0.2778
p.P651Q	TCGA-86-6851	LUAD	TCGA	DSGSHS	DEG_SCF_TRCP1_1	0.2222
p.P651Q	DO23798	LUAD	ICGC	DSGSHS	DEG_SCF_TRCP1_1	0.2222
p.D655Y	TCGA-AJ-A5DW	UCEC	TCGA	DSGSHS	DEG_SCF_TRCP1_1	0.7325
p.D655Y	DO50075	UCEC	ICGC	DSGSHS	DEG_SCF_TRCP1_1	0.7325
p.P652L	TCGA-EB-A430	SKCM	TCGA	DSGSHS	DEG_SCF_TRCP1_1	0.25
p.P652L	DO37906	SKCM	ICGC	DSGSHS	DEG_SCF_TRCP1_1	0.25
p.R649W	TCGA-EE-A2MR	SKCM	TCGA	DSGSHS	DEG_SCF_TRCP1_1	0.1667
p.R649W	TCGA-VS-A958	CESC	TCGA	DSGSHS	DEG_SCF_TRCP1_1	0.1667
p.R649W	DO51639	CESC	ICGC	DSGSHS	DEG_SCF_TRCP1_1	0.1667
p.R649W	DO37819	SKCM	ICGC	DSGSHS	DEG_SCF_TRCP1_1	0.1667
p.S664L	TCGA-EI-6917	READ	TCGA	DSGSHS	DEG_SCF_TRCP1_1	0.6667
p.S664L	DO36881	READ	ICGC	DSGSHS	DEG_SCF_TRCP1_1	0.6667
p.S664L	SIDM00228	Thyroid Gland Carcinoma	GDSC	DSGSHS	DEG_SCF_TRCP1_1	0.6667
p.S664L	ACH-000897	Thyroid Cancer	CCLE	DSGSHS	DEG_SCF_TRCP1_1	0.6667
p.H647Y	TCGA-NC-A5HE	LUSC	TCGA	DSGSHS	DEG_SCF_TRCP1_1	0.1111
p.H647Y	DO45453	LUSC	ICGC	DSGSHS	DEG_SCF_TRCP1_1	0.1111
p.P653Q	TCGA-VQ-AA6K	STAD	TCGA	DSGSHS	DEG_SCF_TRCP1_1	0.2778
p.P653Q	DO222401	STAD	ICGC	DSGSHS	DEG_SCF_TRCP1_1	0.2778
p.R663S	DO233271	GACA	ICGC	DSGSHS	DEG_SCF_TRCP1_1	0.25
p.P650L	DO233760	GACA	ICGC	DSGSHS	DEG_SCF_TRCP1_1	0.1944
p.P650Q	DO231942	LICA	ICGC	DSGSHS	DEG_SCF_TRCP1_1	0.1944
p.P648T	DO229036	LICA	ICGC	DSGSHS	DEG_SCF_TRCP1_1	0.1389
p.P653S	DO50970	LICA	ICGC	DSGSHS	DEG_SCF_TRCP1_1	0.2778
p.Q670P	DO50927	LICA	ICGC	DSGSHS	DEG_SCF_TRCP1_1	0.0556
p.R649Q	SIDM00582	Pancreatic Carcinoma	GDSC	DSGSHS	DEG_SCF_TRCP1_1	0.1667
p.R649Q	ACH-000281	Pancreatic Cancer	CCLE	DSGSHS	DEG_SCF_TRCP1_1	0.1667
p.R649Q	KP-2	pancreas	COSMIC	DSGSHS	DEG_SCF_TRCP1_1	0.1667
p.R649L	SIDM00357	Small Cell Lung Carcinoma	GDSC	DSGSHS	DEG_SCF_TRCP1_1	0.1667
p.R649L	ACH-002193	Lung Cancer	CCLE	DSGSHS	DEG_SCF_TRCP1_1	0.1667
p.R649L	RERF-LC-FM	lung	COSMIC	DSGSHS	DEG_SCF_TRCP1_1	0.1667
p.R667L	SIDM00497	Colorectal Carcinoma	GDSC	DSGSHS	DEG_SCF_TRCP1_1	0.1389
p.R667L	ACH-000683	Colon/Colorectal Cancer	CCLE	DSGSHS	DEG_SCF_TRCP1_1	0.1389
p.L669F	LS-411N	large_intestine	COSMIC	DSGSHS	DEG_SCF_TRCP1_1	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10071	Transcriptional activator GLI3	DEG_SCF_TRCP1_1	655:660	DSGSHS	BTRC	0.9789	More...
P48378	DNA-binding protein RFX2	DEG_SCF_TRCP1_1	312:317	DSGSHS	BTRC	0.7867	More...
Q96N21	AP-4 complex accessory subunit Tepsin	DEG_SCF_TRCP1_1	211:216	DSGSHS	BTRC	0.9272	More...
Q9GZV5	WW domain-containing transcription regulator protein 1	DEG_SCF_TRCP1_1	57:62	DSGSHS	BTRC	0.9953	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGSHS

Degron related mutations and impact score

Drug responses associated with GLI3 mutations

All proteins holding degron of DSGSHS