DegronMD

Uniprot ID: P48378

Source protein: DNA-binding protein RFX2

Source gene: RFX2

Class: DEG_SCF_TRCP1_1

Location: 312:317

E3 ligase: BTRC

DEGRON score: 0.7867

ASA_SCORE: 62.2833

COIL: 0.7847

CONS_SCORE: 0.3285

DSS_SCORE: 0.799

HELIX: 0.1158

FCONS_SCORE: 1.0238

RIG_SCORE: 0.4803

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T307M	TCGA-L5-A4OI	ESCA	TCGA	DSGSHS	DEG_SCF_TRCP1_1	0.1944
p.G311R	DO229343	BTCA	ICGC	DSGSHS	DEG_SCF_TRCP1_1	0.3056
p.G311R	SIDM01879	Non-Cancerous	GDSC	DSGSHS	DEG_SCF_TRCP1_1	0.3056
p.P303T	DO232761	PBCA	ICGC	DSGSHS	DEG_SCF_TRCP1_1	0.0833
p.G318S	SIDM00654	Small Cell Lung Carcinoma	GDSC	DSGSHS	DEG_SCF_TRCP1_1	0.3056
p.L319V	SIDM00317	Kidney Carcinoma	GDSC	DSGSHS	DEG_SCF_TRCP1_1	0.2778
p.L319V	SIDM00090	Ovarian Carcinoma	GDSC	DSGSHS	DEG_SCF_TRCP1_1	0.2778
p.L319V	SIDM00181	Bladder Carcinoma	GDSC	DSGSHS	DEG_SCF_TRCP1_1	0.2778
p.L319V	SIDM01646	Non-Cancerous	GDSC	DSGSHS	DEG_SCF_TRCP1_1	0.2778
p.R302Q	SIDM01263	T-Lymphoblastic Leukemia	GDSC	DSGSHS	DEG_SCF_TRCP1_1	0.0556
p.R302Q	ACH-000995	Leukemia	CCLE	DSGSHS	DEG_SCF_TRCP1_1	0.0556
p.P320L	Mewo	skin	COSMIC	DSGSHS	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10071	Transcriptional activator GLI3	DEG_SCF_TRCP1_1	655:660	DSGSHS	BTRC	0.9789	More...
P48378	DNA-binding protein RFX2	DEG_SCF_TRCP1_1	312:317	DSGSHS	BTRC	0.7867	More...
Q96N21	AP-4 complex accessory subunit Tepsin	DEG_SCF_TRCP1_1	211:216	DSGSHS	BTRC	0.9272	More...
Q9GZV5	WW domain-containing transcription regulator protein 1	DEG_SCF_TRCP1_1	57:62	DSGSHS	BTRC	0.9953	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons