DegronMD

Uniprot ID: Q9GZV5

Source protein: WW domain-containing transcription regulator protein 1

Source gene: WWTR1

Class: DEG_SCF_TRCP1_1

Location: 57:62

E3 ligase: BTRC

DEGRON score: 0.9953

ASA_SCORE: 79.45

COIL: 0.8847

CONS_SCORE: 0.4764

DSS_SCORE: 0.693

HELIX: 0.0807

FCONS_SCORE: 1.0149

RIG_SCORE: 0.5265

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K54E	TCGA-GF-A3OT	SKCM	TCGA	DSGSHS	DEG_SCF_TRCP1_1	0.3611
p.K54E	DO47288	SKCM	ICGC	DSGSHS	DEG_SCF_TRCP1_1	0.3611
p.G72C	SIDM00729	Non-Small Cell Lung Carcinoma	GDSC	DSGSHS	DEG_SCF_TRCP1_1	0.0556
p.G72C	ACH-000447	Lung Cancer	CCLE	DSGSHS	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10071	Transcriptional activator GLI3	DEG_SCF_TRCP1_1	655:660	DSGSHS	BTRC	0.9789	More...
P48378	DNA-binding protein RFX2	DEG_SCF_TRCP1_1	312:317	DSGSHS	BTRC	0.7867	More...
Q96N21	AP-4 complex accessory subunit Tepsin	DEG_SCF_TRCP1_1	211:216	DSGSHS	BTRC	0.9272	More...
Q9GZV5	WW domain-containing transcription regulator protein 1	DEG_SCF_TRCP1_1	57:62	DSGSHS	BTRC	0.9953	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons