DegronMD - P48378(RFX2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T105M	TCGA-EO-A22U	UCEC	TCGA	APSST	DEG_SPOP_SBC_1	101:105	Mutation altering degron motif	0.7423
p.T105M	DO43755	UCEC	ICGC	APSST	DEG_SPOP_SBC_1	101:105	Mutation altering degron motif	0.7423
p.T307M	TCGA-L5-A4OI	ESCA	TCGA	DSGSHS	DEG_SCF_TRCP1_1	312:317	Mutation rewiring degron network	0.1944
p.E96K	TCGA-ZF-A9RL	BLCA	TCGA	APSST	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.1944
p.E96K	DO219078	BLCA	ICGC	APSST	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.1944
p.E96K	DO33091	PACA	ICGC	APSST	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.1944
p.G311R	DO229343	BTCA	ICGC	DSGSHS	DEG_SCF_TRCP1_1	312:317	Mutation rewiring degron network	0.3056
p.G311R	SIDM01879	Non-Cancerous	GDSC	DSGSHS	DEG_SCF_TRCP1_1	312:317	Mutation rewiring degron network	0.3056
p.A111D	DO229027	LICA	ICGC	APSST	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.1667
p.P95L	DO220878	MELA	ICGC	APSST	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.1667
p.G114N	DO222843	MELA	ICGC	APSST	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.0833
p.P303T	DO232761	PBCA	ICGC	DSGSHS	DEG_SCF_TRCP1_1	312:317	Mutation rewiring degron network	0.0833
p.M99I	DO229259	THCA	ICGC	APSST	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.2778
p.Y91N	DO229275	THCA	ICGC	APSST	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.0556
p.Q98H	DO229221	THCA	ICGC	APSST	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.25
p.A115T	DO229240	THCA	ICGC	APSST	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.0556
p.G318S	SIDM00654	Small Cell Lung Carcinoma	GDSC	DSGSHS	DEG_SCF_TRCP1_1	312:317	Mutation rewiring degron network	0.3056
p.A101T	SIDM00449	B-Lymphoblastic Leukemia	GDSC	APSST	DEG_SPOP_SBC_1	101:105	Mutation altering degron motif	0.7139
p.A101T	SIDM00686	Endometrial Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	101:105	Mutation altering degron motif	0.7139
p.A101T	KLE	endometrium	COSMIC	APSST	DEG_SPOP_SBC_1	101:105	Mutation altering degron motif	0.7139
p.A101T	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	APSST	DEG_SPOP_SBC_1	101:105	Mutation altering degron motif	0.7139
p.L319V	SIDM00317	Kidney Carcinoma	GDSC	DSGSHS	DEG_SCF_TRCP1_1	312:317	Mutation rewiring degron network	0.2778
p.L319V	SIDM00090	Ovarian Carcinoma	GDSC	DSGSHS	DEG_SCF_TRCP1_1	312:317	Mutation rewiring degron network	0.2778
p.L319V	SIDM00181	Bladder Carcinoma	GDSC	DSGSHS	DEG_SCF_TRCP1_1	312:317	Mutation rewiring degron network	0.2778
p.L319V	SIDM01646	Non-Cancerous	GDSC	DSGSHS	DEG_SCF_TRCP1_1	312:317	Mutation rewiring degron network	0.2778
p.R302Q	SIDM01263	T-Lymphoblastic Leukemia	GDSC	DSGSHS	DEG_SCF_TRCP1_1	312:317	Mutation rewiring degron network	0.0556
p.R302Q	ACH-000995	Leukemia	CCLE	DSGSHS	DEG_SCF_TRCP1_1	312:317	Mutation rewiring degron network	0.0556
p.P320L	Mewo	skin	COSMIC	DSGSHS	DEG_SCF_TRCP1_1	312:317	Mutation rewiring degron network	0.25

Kaplan plot for RFX2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RFX2

UniProt ID: P48378

Entrez ID: 5990

Protein name: DNA-binding protein RFX2 (Regulatory factor X 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RFX2 in