DegronMD - Q7L590(MCM10)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P649Q	TCGA-17-Z001	LUAD	TCGA	PRPKLSALA	DEG_APCC_DBOX_1	647:655	Mutation altering degron motif	0.5924
p.N221K	TCGA-23-1121	OV	TCGA	IVGTPGSS	DEG_SCF_FBW7_1	231:238	Mutation rewiring degron network	0.0556
p.E63K	TCGA-2W-A8YY	CESC	TCGA	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation altering degron motif	0.7022
p.E63K	DO223732	CESC	ICGC	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation altering degron motif	0.7022
p.L651R	TCGA-A8-A07W	BRCA	TCGA	PRPKLSALA	DEG_APCC_DBOX_1	647:655	Mutation altering degron motif	0.8428
p.L651R	DO1297	BRCA	ICGC	PRPKLSALA	DEG_APCC_DBOX_1	647:655	Mutation altering degron motif	0.8428
p.A75V	TCGA-A8-A09Z	BRCA	TCGA	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation rewiring degron network	0.0833
p.A75V	TCGA-B4-5377	KIRC	TCGA	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation rewiring degron network	0.0833
p.A75V	DO5521	BRCA	ICGC	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation rewiring degron network	0.0833
p.A75V	DO20229	KIRC	ICGC	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation rewiring degron network	0.0833
p.L651M	TCGA-AA-A010	COAD	TCGA	PRPKLSALA	DEG_APCC_DBOX_1	647:655	Mutation altering degron motif	0.711
p.R609Q	TCGA-AX-A06F	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	596:600	Mutation rewiring degron network	0.0833
p.R609Q	DO41752	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	596:600	Mutation rewiring degron network	0.0833
p.R609Q	SIDM00214	Colorectal Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	596:600	Mutation rewiring degron network	0.0833
p.R609Q	ACH-000955	Colon/Colorectal Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	596:600	Mutation rewiring degron network	0.0833
p.R609Q	SNU-407	large intestine	COSMIC	VPSSS	DEG_SPOP_SBC_1	596:600	Mutation rewiring degron network	0.0833
p.E70K	TCGA-AZ-4315	COAD	TCGA	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation rewiring degron network	0.2222
p.E70K	DO8842	COAD	ICGC	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation rewiring degron network	0.2222
p.D179V	TCGA-B0-5700	KIRC	TCGA	VARTPKAS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.0556
p.R185I	TCGA-B5-A0JY	UCEC	TCGA	VARTPKAS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.2222
p.R185I	TCGA-ER-A19Q	SKCM	TCGA	VARTPKAS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.2222
p.P200L	TCGA-B5-A3FC	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.7582
p.P200L	TCGA-DA-A3F8	SKCM	TCGA	PKSSS	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.7582
p.P647Q	TCGA-BF-A1Q0	SKCM	TCGA	PRPKLSALA	DEG_APCC_DBOX_1	647:655	Mutation altering degron motif	0.5924
p.P647Q	DO47374	SKCM	ICGC	PRPKLSALA	DEG_APCC_DBOX_1	647:655	Mutation altering degron motif	0.5924
p.D51N	TCGA-CA-5256	COAD	TCGA	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation rewiring degron network	0.0556
p.D51N	TCGA-D1-A16F	UCEC	TCGA	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation rewiring degron network	0.0556
p.D51N	DO10526	COAD	ICGC	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation rewiring degron network	0.0556
p.D51N	DO42408	UCEC	ICGC	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation rewiring degron network	0.0556
p.S238P	TCGA-CJ-4643	KIRC	TCGA	IVGTPGSS	DEG_SCF_FBW7_1	231:238	Mutation altering degron motif	0.7863
p.P197H	TCGA-CV-7178	HNSC	TCGA	VARTPKAS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.3056
p.P197H	TCGA-CV-7178	HNSC	TCGA	PKSSS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.25
p.K194E	TCGA-DD-AAC8	LIHC	TCGA	VARTPKAS	DEG_SCF_FBW7_1	189:196	Mutation altering degron motif	0.591
p.S593I	TCGA-DX-A6YT	SARC	TCGA	VPSSS	DEG_SPOP_SBC_1	596:600	Mutation blocking phosphorylation signal	0.6944
p.S593I	DO220007	SARC	ICGC	VPSSS	DEG_SPOP_SBC_1	596:600	Mutation blocking phosphorylation signal	0.6944
p.Q243E	TCGA-EK-A2PL	CESC	TCGA	IVGTPGSS	DEG_SCF_FBW7_1	231:238	Mutation rewiring degron network	0.1944
p.R609W	TCGA-HU-A4GQ	STAD	TCGA	VPSSS	DEG_SPOP_SBC_1	596:600	Mutation rewiring degron network	0.0833
p.R609W	DO222973	BTCA	ICGC	VPSSS	DEG_SPOP_SBC_1	596:600	Mutation rewiring degron network	0.0833
p.R609W	DO47767	STAD	ICGC	VPSSS	DEG_SPOP_SBC_1	596:600	Mutation rewiring degron network	0.0833
p.P647A	TCGA-KD-A5QS	SARC	TCGA	PRPKLSALA	DEG_APCC_DBOX_1	647:655	Mutation altering degron motif	0.6392
p.P647A	DO223270	SARC	ICGC	PRPKLSALA	DEG_APCC_DBOX_1	647:655	Mutation altering degron motif	0.6392
p.R228S	TCGA-UB-A7MB	LIHC	TCGA	IVGTPGSS	DEG_SCF_FBW7_1	231:238	Mutation rewiring degron network	0.25
p.A661S	TCGA-WK-A8XS	SARC	TCGA	PRPKLSALA	DEG_APCC_DBOX_1	647:655	Mutation rewiring degron network	0.1667
p.A661S	DO220297	SARC	ICGC	PRPKLSALA	DEG_APCC_DBOX_1	647:655	Mutation rewiring degron network	0.1667
p.D60N	TCGA-XF-AAMZ	BLCA	TCGA	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation rewiring degron network	0.3056
p.D60N	DO219051	BLCA	ICGC	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation rewiring degron network	0.3056
p.D60N	SIDM02020	Esophageal Carcinoma	GDSC	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation rewiring degron network	0.3056
p.R68K	TCGA-XF-AAMZ	BLCA	TCGA	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation rewiring degron network	0.2778
p.R68K	DO219051	BLCA	ICGC	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation rewiring degron network	0.2778
p.D69N	TCGA-XF-AAMZ	BLCA	TCGA	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation rewiring degron network	0.25
p.D69N	DO219051	BLCA	ICGC	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation rewiring degron network	0.25
p.S238F	TCGA-Z2-A8RT	SKCM	TCGA	IVGTPGSS	DEG_SCF_FBW7_1	231:238	Mutation altering degron motif	0.9093
p.D61N	DO228246	BRCA	ICGC	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation altering degron motif	0.5821
p.Q242E	DO48979	CESC	ICGC	IVGTPGSS	DEG_SCF_FBW7_1	231:238	Mutation rewiring degron network	0.2222
p.D642H	DO234225	ESAD	ICGC	PRPKLSALA	DEG_APCC_DBOX_1	647:655	Mutation rewiring degron network	0.1944
p.S644P	DO218693	GACA	ICGC	PRPKLSALA	DEG_APCC_DBOX_1	647:655	Mutation blocking phosphorylation signal	0.6944
p.P196H	DO14774	HNSC	ICGC	VARTPKAS	DEG_SCF_FBW7_1	189:196	Mutation altering degron motif	0.7694
p.S237P	DO18124	KIRC	ICGC	IVGTPGSS	DEG_SCF_FBW7_1	231:238	Mutation altering degron motif	0.5641
p.A189S	DO228936	LICA	ICGC	VARTPKAS	DEG_SCF_FBW7_1	189:196	Mutation altering degron motif	0.7588
p.R205S	DO229019	LICA	ICGC	VARTPKAS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.0833
p.R205S	DO229019	LICA	ICGC	PKSSS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.3056
p.R609L	DO229022	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	596:600	Mutation rewiring degron network	0.0833
p.D51Y	DO229031	LICA	ICGC	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation rewiring degron network	0.0556
p.A662S	DO229038	LICA	ICGC	PRPKLSALA	DEG_APCC_DBOX_1	647:655	Mutation rewiring degron network	0.1389
p.S201I	DO229009	LICA	ICGC	PKSSS	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.7341
p.R227S	DO52318	LIHC	ICGC	IVGTPGSS	DEG_SCF_FBW7_1	231:238	Mutation rewiring degron network	0.2222
p.K193E	DO52193	LIHC	ICGC	VARTPKAS	DEG_SCF_FBW7_1	189:196	Mutation altering degron motif	0.7022
p.V638A	DO45299	LIRI	ICGC	PRPKLSALA	DEG_APCC_DBOX_1	647:655	Mutation rewiring degron network	0.0833
p.Q242K	DO224563	LUSC	ICGC	IVGTPGSS	DEG_SCF_FBW7_1	231:238	Mutation rewiring degron network	0.2222
p.Q606H	DO224563	LUSC	ICGC	VPSSS	DEG_SPOP_SBC_1	596:600	Mutation rewiring degron network	0.1667
p.S54F	DO222653	MELA	ICGC	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation blocking phosphorylation signal	0.5833
p.S208R	DO222753	MELA	ICGC	PKSSS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2222
p.A657D	DO35763	PBCA	ICGC	PRPKLSALA	DEG_APCC_DBOX_1	647:655	Mutation rewiring degron network	0.2778
p.P199L	DO37418	SKCM	ICGC	VARTPKAS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.25
p.P199L	DO37418	SKCM	ICGC	PKSSS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.3056
p.P199L	DO41871	UCEC	ICGC	VARTPKAS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.25
p.P199L	DO41871	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.3056
p.R184I	DO47497	SKCM	ICGC	VARTPKAS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.1944
p.R184I	DO43041	UCEC	ICGC	VARTPKAS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.1944
p.S237F	DO51301	SKCM	ICGC	IVGTPGSS	DEG_SCF_FBW7_1	231:238	Mutation altering degron motif	0.6871
p.G52S	SIDM01268	Colorectal Carcinoma	GDSC	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation rewiring degron network	0.0833
p.Q230L	SIDM00831	Head and Neck Carcinoma	GDSC	IVGTPGSS	DEG_SCF_FBW7_1	231:238	Mutation rewiring degron network	0.3056
p.Q230L	ACH-000207	Head and Neck Cancer	CCLE	IVGTPGSS	DEG_SCF_FBW7_1	231:238	Mutation rewiring degron network	0.3056
p.Q230L	Detroit562	upper aerodigestive tract	COSMIC	IVGTPGSS	DEG_SCF_FBW7_1	231:238	Mutation rewiring degron network	0.3056
p.E590K	SIDM00386	Ewing's Sarcoma	GDSC	VPSSS	DEG_SPOP_SBC_1	596:600	Mutation rewiring degron network	0.1667
p.E590K	ACH-000391	Bone Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	596:600	Mutation rewiring degron network	0.1667
p.E590K	MHH-ES-1	bone	COSMIC	VPSSS	DEG_SPOP_SBC_1	596:600	Mutation rewiring degron network	0.1667
p.E57K	SIDM00333	Endometrial Carcinoma	GDSC	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation rewiring degron network	0.2222
p.E57K	ACH-000988	Endometrial/Uterine Cancer	CCLE	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation rewiring degron network	0.2222
p.E57K	MFE-319	endometrium	COSMIC	DGETGE	DEG_Kelch_Keap1_1	61:66	Mutation rewiring degron network	0.2222
p.R191Q	SIDM01045	Endometrial Carcinoma	GDSC	VARTPKAS	DEG_SCF_FBW7_1	189:196	Mutation altering degron motif	0.6218
p.R191Q	ACH-000978	Endometrial/Uterine Cancer	CCLE	VARTPKAS	DEG_SCF_FBW7_1	189:196	Mutation altering degron motif	0.6218
p.R191Q	EN	endometrium	COSMIC	VARTPKAS	DEG_SCF_FBW7_1	189:196	Mutation altering degron motif	0.6218
p.T241M	SIDM00097	Breast Carcinoma	GDSC	IVGTPGSS	DEG_SCF_FBW7_1	231:238	Mutation rewiring degron network	0.25
p.T241M	SIDM00861	Ovarian Carcinoma	GDSC	IVGTPGSS	DEG_SCF_FBW7_1	231:238	Mutation rewiring degron network	0.25
p.S600L	SIDM00999	Bladder Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	596:600	Mutation altering degron motif	0.7667
p.S600L	ACH-000973	Bladder Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	596:600	Mutation altering degron motif	0.7667
p.S600L	639-V	urinary tract	COSMIC	VPSSS	DEG_SPOP_SBC_1	596:600	Mutation altering degron motif	0.7667
p.P198A	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	VARTPKAS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.2778
p.P198A	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2778
p.P198A	ACH-000717	Esophageal Cancer	CCLE	VARTPKAS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.2778
p.P198A	ACH-000717	Esophageal Cancer	CCLE	PKSSS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2778
p.P198A	COLO-680N	oesophagus	COSMIC	VARTPKAS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.2778
p.P198A	COLO-680N	oesophagus	COSMIC	PKSSS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2778
p.S589R	SIDM01254	Burkitt's Lymphoma	GDSC	VPSSS	DEG_SPOP_SBC_1	596:600	Mutation rewiring degron network	0.1389
p.S589R	ACH-000707	Lymphoma	CCLE	VPSSS	DEG_SPOP_SBC_1	596:600	Mutation rewiring degron network	0.1389
p.S599L	639-V	urinary tract	COSMIC	VPSSS	DEG_SPOP_SBC_1	596:600	Mutation altering degron motif	0.7667
p.P197A	COLO-680N	oesophagus	COSMIC	VARTPKAS	DEG_SCF_FBW7_1	189:196	Mutation rewiring degron network	0.3056
p.P197A	COLO-680N	oesophagus	COSMIC	PKSSS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.25
p.Q229L	Detroit562	upper aerodigestive tract	COSMIC	IVGTPGSS	DEG_SCF_FBW7_1	231:238	Mutation rewiring degron network	0.2778
p.E589K	MHH-ES-1	bone	COSMIC	VPSSS	DEG_SPOP_SBC_1	596:600	Mutation rewiring degron network	0.1389
p.R608Q	SNU-407	large intestine	COSMIC	VPSSS	DEG_SPOP_SBC_1	596:600	Mutation rewiring degron network	0.1111
p.R190Q	EN	endometrium	COSMIC	VARTPKAS	DEG_SCF_FBW7_1	189:196	Mutation altering degron motif	0.7329

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MCM10

UniProt ID: Q7L590

Entrez ID: 55388

Protein name: Protein MCM10 homolog (HsMCM10)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MCM10 in