DegronMD

Uniprot ID: Q7L590

Source protein: Protein MCM10 homolog

Source gene: MCM10

Class: DEG_Kelch_Keap1_1

Location: 61:66

E3 ligase: KEAP1

DEGRON score: 0.9209

ASA_SCORE: 95.9833

COIL: 0.8627

CONS_SCORE: 0.3067

DSS_SCORE: 0.837

HELIX: 0.127

FCONS_SCORE: 1.0041

RIG_SCORE: 0.6278

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E63K	TCGA-2W-A8YY	CESC	TCGA	DGETGE	DEG_Kelch_Keap1_1	0.7022
p.E63K	DO223732	CESC	ICGC	DGETGE	DEG_Kelch_Keap1_1	0.7022
p.A75V	TCGA-A8-A09Z	BRCA	TCGA	DGETGE	DEG_Kelch_Keap1_1	0.0833
p.A75V	TCGA-B4-5377	KIRC	TCGA	DGETGE	DEG_Kelch_Keap1_1	0.0833
p.A75V	DO5521	BRCA	ICGC	DGETGE	DEG_Kelch_Keap1_1	0.0833
p.A75V	DO20229	KIRC	ICGC	DGETGE	DEG_Kelch_Keap1_1	0.0833
p.E70K	TCGA-AZ-4315	COAD	TCGA	DGETGE	DEG_Kelch_Keap1_1	0.2222
p.E70K	DO8842	COAD	ICGC	DGETGE	DEG_Kelch_Keap1_1	0.2222
p.D51N	TCGA-CA-5256	COAD	TCGA	DGETGE	DEG_Kelch_Keap1_1	0.0556
p.D51N	TCGA-D1-A16F	UCEC	TCGA	DGETGE	DEG_Kelch_Keap1_1	0.0556
p.D51N	DO10526	COAD	ICGC	DGETGE	DEG_Kelch_Keap1_1	0.0556
p.D51N	DO42408	UCEC	ICGC	DGETGE	DEG_Kelch_Keap1_1	0.0556
p.D60N	TCGA-XF-AAMZ	BLCA	TCGA	DGETGE	DEG_Kelch_Keap1_1	0.3056
p.D60N	DO219051	BLCA	ICGC	DGETGE	DEG_Kelch_Keap1_1	0.3056
p.D60N	SIDM02020	Esophageal Carcinoma	GDSC	DGETGE	DEG_Kelch_Keap1_1	0.3056
p.R68K	TCGA-XF-AAMZ	BLCA	TCGA	DGETGE	DEG_Kelch_Keap1_1	0.2778
p.R68K	DO219051	BLCA	ICGC	DGETGE	DEG_Kelch_Keap1_1	0.2778
p.D69N	TCGA-XF-AAMZ	BLCA	TCGA	DGETGE	DEG_Kelch_Keap1_1	0.25
p.D69N	DO219051	BLCA	ICGC	DGETGE	DEG_Kelch_Keap1_1	0.25
p.D61N	DO228246	BRCA	ICGC	DGETGE	DEG_Kelch_Keap1_1	0.5821
p.D51Y	DO229031	LICA	ICGC	DGETGE	DEG_Kelch_Keap1_1	0.0556
p.S54F	DO222653	MELA	ICGC	DGETGE	DEG_Kelch_Keap1_1	0.5833
p.G52S	SIDM01268	Colorectal Carcinoma	GDSC	DGETGE	DEG_Kelch_Keap1_1	0.0833
p.E57K	SIDM00333	Endometrial Carcinoma	GDSC	DGETGE	DEG_Kelch_Keap1_1	0.2222
p.E57K	ACH-000988	Endometrial/Uterine Cancer	CCLE	DGETGE	DEG_Kelch_Keap1_1	0.2222
p.E57K	MFE-319	endometrium	COSMIC	DGETGE	DEG_Kelch_Keap1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14494	Endoplasmic reticulum membrane sensor NFE2L1	DEG_Kelch_Keap1_1	231:236	DGETGE	KEAP1	0.9809	More...
Q7L590	Protein MCM10 homolog	DEG_Kelch_Keap1_1	61:66	DGETGE	KEAP1	0.9209	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DGETGE

Degron related mutations and impact score

Drug responses associated with MCM10 mutations

All proteins holding degron of DGETGE