DegronMD

Uniprot ID: Q14494

Source protein: Endoplasmic reticulum membrane sensor NFE2L1

Source gene: NFE2L1

Class: DEG_Kelch_Keap1_1

Location: 231:236

E3 ligase: KEAP1

DEGRON score: 0.9809

ASA_SCORE: 82.3667

COIL: 0.8747

CONS_SCORE: 0.5731

DSS_SCORE: 0.5186

HELIX: 0.0835

FCONS_SCORE: 1.391

RIG_SCORE: 0.6773

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L221F	DO49941	CESC	ICGC	DGETGE	DEG_Kelch_Keap1_1	0.0556
p.P239L	DO234274	ESAD	ICGC	DGETGE	DEG_Kelch_Keap1_1	0.25
p.L221V	DO19058	KIRC	ICGC	DGETGE	DEG_Kelch_Keap1_1	0.0556
p.A231S	DO229022	LICA	ICGC	DGETGE	DEG_Kelch_Keap1_1	0.7588
p.A232S	DO22854	LIHC	ICGC	DGETGE	DEG_Kelch_Keap1_1	0.7588
p.P242H	DO43306	UCEC	ICGC	DGETGE	DEG_Kelch_Keap1_1	0.1667
p.R226Q	SIDM01343	Gastric Carcinoma	GDSC	DGETGE	DEG_Kelch_Keap1_1	0.1944
p.P232R	JIMT-1	breast	COSMIC	DGETGE	DEG_Kelch_Keap1_1	0.7512
p.L225M	FADU	upper_aerodigestive_tract	COSMIC	DGETGE	DEG_Kelch_Keap1_1	0.1667
p.P221R	JIMT-1	breast	COSMIC	DGETGE	DEG_Kelch_Keap1_1	0.0556
p.V226M	D-245MG	central_nervous_system	COSMIC	DGETGE	DEG_Kelch_Keap1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14494	Endoplasmic reticulum membrane sensor NFE2L1	DEG_Kelch_Keap1_1	231:236	DGETGE	KEAP1	0.9809	More...
Q7L590	Protein MCM10 homolog	DEG_Kelch_Keap1_1	61:66	DGETGE	KEAP1	0.9209	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons