DegronMD

Uniprot ID: Q7L590

Source protein: Protein MCM10 homolog

Source gene: MCM10

Class: DEG_APCC_DBOX_1

Location: 647:655

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5833

ASA_SCORE: 83.8778

COIL: 0.564

CONS_SCORE: 0.3164

DSS_SCORE: 0.4687

HELIX: 0.4261

FCONS_SCORE: 0.9357

RIG_SCORE: 0.7402

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P649Q	TCGA-17-Z001	LUAD	TCGA	PRPKLSALA	DEG_APCC_DBOX_1	0.5924
p.L651R	TCGA-A8-A07W	BRCA	TCGA	PRPKLSALA	DEG_APCC_DBOX_1	0.8428
p.L651R	DO1297	BRCA	ICGC	PRPKLSALA	DEG_APCC_DBOX_1	0.8428
p.L651M	TCGA-AA-A010	COAD	TCGA	PRPKLSALA	DEG_APCC_DBOX_1	0.711
p.P647Q	TCGA-BF-A1Q0	SKCM	TCGA	PRPKLSALA	DEG_APCC_DBOX_1	0.5924
p.P647Q	DO47374	SKCM	ICGC	PRPKLSALA	DEG_APCC_DBOX_1	0.5924
p.P647A	TCGA-KD-A5QS	SARC	TCGA	PRPKLSALA	DEG_APCC_DBOX_1	0.6392
p.P647A	DO223270	SARC	ICGC	PRPKLSALA	DEG_APCC_DBOX_1	0.6392
p.A661S	TCGA-WK-A8XS	SARC	TCGA	PRPKLSALA	DEG_APCC_DBOX_1	0.1667
p.A661S	DO220297	SARC	ICGC	PRPKLSALA	DEG_APCC_DBOX_1	0.1667
p.D642H	DO234225	ESAD	ICGC	PRPKLSALA	DEG_APCC_DBOX_1	0.1944
p.S644P	DO218693	GACA	ICGC	PRPKLSALA	DEG_APCC_DBOX_1	0.6944
p.A662S	DO229038	LICA	ICGC	PRPKLSALA	DEG_APCC_DBOX_1	0.1389
p.V638A	DO45299	LIRI	ICGC	PRPKLSALA	DEG_APCC_DBOX_1	0.0833
p.A657D	DO35763	PBCA	ICGC	PRPKLSALA	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L590	Protein MCM10 homolog	DEG_APCC_DBOX_1	647:655	PRPKLSALA	APC,CDC20,FZR1	0.5833	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons