DegronMD

Uniprot ID: Q7L590

Source protein: Protein MCM10 homolog

Source gene: MCM10

Class: DEG_SCF_FBW7_1

Location: 231:238

E3 ligase: FBXW7

DEGRON score: 0.977

ASA_SCORE: 75.0375

COIL: 0.8978

CONS_SCORE: 0.3271

DSS_SCORE: 0.6523

HELIX: 0.0193

FCONS_SCORE: 0.9333

RIG_SCORE: 0.6004

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N221K	TCGA-23-1121	OV	TCGA	IVGTPGSS	DEG_SCF_FBW7_1	0.0556
p.S238P	TCGA-CJ-4643	KIRC	TCGA	IVGTPGSS	DEG_SCF_FBW7_1	0.7863
p.Q243E	TCGA-EK-A2PL	CESC	TCGA	IVGTPGSS	DEG_SCF_FBW7_1	0.1944
p.R228S	TCGA-UB-A7MB	LIHC	TCGA	IVGTPGSS	DEG_SCF_FBW7_1	0.25
p.S238F	TCGA-Z2-A8RT	SKCM	TCGA	IVGTPGSS	DEG_SCF_FBW7_1	0.9093
p.Q242E	DO48979	CESC	ICGC	IVGTPGSS	DEG_SCF_FBW7_1	0.2222
p.S237P	DO18124	KIRC	ICGC	IVGTPGSS	DEG_SCF_FBW7_1	0.5641
p.R227S	DO52318	LIHC	ICGC	IVGTPGSS	DEG_SCF_FBW7_1	0.2222
p.Q242K	DO224563	LUSC	ICGC	IVGTPGSS	DEG_SCF_FBW7_1	0.2222
p.S237F	DO51301	SKCM	ICGC	IVGTPGSS	DEG_SCF_FBW7_1	0.6871
p.Q230L	SIDM00831	Head and Neck Carcinoma	GDSC	IVGTPGSS	DEG_SCF_FBW7_1	0.3056
p.Q230L	ACH-000207	Head and Neck Cancer	CCLE	IVGTPGSS	DEG_SCF_FBW7_1	0.3056
p.Q230L	Detroit562	upper_aerodigestive_tract	COSMIC	IVGTPGSS	DEG_SCF_FBW7_1	0.3056
p.T241M	SIDM00097	Breast Carcinoma	GDSC	IVGTPGSS	DEG_SCF_FBW7_1	0.25
p.T241M	SIDM00861	Ovarian Carcinoma	GDSC	IVGTPGSS	DEG_SCF_FBW7_1	0.25
p.Q229L	Detroit562	upper_aerodigestive_tract	COSMIC	IVGTPGSS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L590	Protein MCM10 homolog	DEG_SCF_FBW7_1	231:238	IVGTPGSS	FBXW7	0.977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons