DegronMD

Uniprot ID: Q7L590

Source protein: Protein MCM10 homolog

Source gene: MCM10

Class: DEG_SCF_FBW7_1

Location: 189:196

E3 ligase: FBXW7

DEGRON score: 0.8753

ASA_SCORE: 105.625

COIL: 0.9489

CONS_SCORE: 0.3044

DSS_SCORE: 0.7455

HELIX: 0.0263

FCONS_SCORE: 0.95

RIG_SCORE: 0.6088

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D179V	TCGA-B0-5700	KIRC	TCGA	VARTPKAS	DEG_SCF_FBW7_1	0.0556
p.R185I	TCGA-B5-A0JY	UCEC	TCGA	VARTPKAS	DEG_SCF_FBW7_1	0.2222
p.R185I	TCGA-ER-A19Q	SKCM	TCGA	VARTPKAS	DEG_SCF_FBW7_1	0.2222
p.P197H	TCGA-CV-7178	HNSC	TCGA	VARTPKAS	DEG_SCF_FBW7_1	0.3056
p.K194E	TCGA-DD-AAC8	LIHC	TCGA	VARTPKAS	DEG_SCF_FBW7_1	0.591
p.P196H	DO14774	HNSC	ICGC	VARTPKAS	DEG_SCF_FBW7_1	0.7694
p.A189S	DO228936	LICA	ICGC	VARTPKAS	DEG_SCF_FBW7_1	0.7588
p.R205S	DO229019	LICA	ICGC	VARTPKAS	DEG_SCF_FBW7_1	0.0833
p.K193E	DO52193	LIHC	ICGC	VARTPKAS	DEG_SCF_FBW7_1	0.7022
p.P199L	DO37418	SKCM	ICGC	VARTPKAS	DEG_SCF_FBW7_1	0.25
p.P199L	DO41871	UCEC	ICGC	VARTPKAS	DEG_SCF_FBW7_1	0.25
p.R184I	DO47497	SKCM	ICGC	VARTPKAS	DEG_SCF_FBW7_1	0.1944
p.R184I	DO43041	UCEC	ICGC	VARTPKAS	DEG_SCF_FBW7_1	0.1944
p.R191Q	SIDM01045	Endometrial Carcinoma	GDSC	VARTPKAS	DEG_SCF_FBW7_1	0.6218
p.R191Q	ACH-000978	Endometrial/Uterine Cancer	CCLE	VARTPKAS	DEG_SCF_FBW7_1	0.6218
p.R191Q	EN	endometrium	COSMIC	VARTPKAS	DEG_SCF_FBW7_1	0.6218
p.P198A	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	VARTPKAS	DEG_SCF_FBW7_1	0.2778
p.P198A	ACH-000717	Esophageal Cancer	CCLE	VARTPKAS	DEG_SCF_FBW7_1	0.2778
p.P198A	COLO-680N	oesophagus	COSMIC	VARTPKAS	DEG_SCF_FBW7_1	0.2778
p.P197A	COLO-680N	oesophagus	COSMIC	VARTPKAS	DEG_SCF_FBW7_1	0.3056
p.R190Q	EN	endometrium	COSMIC	VARTPKAS	DEG_SCF_FBW7_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L590	Protein MCM10 homolog	DEG_SCF_FBW7_1	189:196	VARTPKAS	FBXW7	0.8753	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons