DegronMD - Q5TCZ1(SH3PXD2A)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S619I	TCGA-77-7142	LUSC	TCGA	FRPYAE	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.1667
p.S619I	DO26462	LUSC	ICGC	FRPYAE	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.1667
p.I666V	TCGA-BH-A0BT	BRCA	TCGA	PKSSS	DEG_SPOP_SBC_1	663:667	Mutation altering degron motif	0.7076
p.E260Q	TCGA-C8-A12T	BRCA	TCGA	RRWTLGGMV	DEG_APCC_DBOX_1	253:261	Mutation altering degron motif	0.6744
p.S676C	TCGA-CN-A63W	HNSC	TCGA	PKSSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.0833
p.S676C	DO49031	HNSC	ICGC	PKSSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.0833
p.S674C	TCGA-D5-6928	COAD	TCGA	PKSSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.1389
p.S674Y	TCGA-F7-A623	HNSC	TCGA	PKSSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.1389
p.E672V	DO222751	BTCA	ICGC	PKSSS	DEG_SPOP_SBC_1	663:667	Mutation substituting flanking lysine	0.3056
p.K631N	DO7878	COAD	ICGC	FRPYAE	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.3056
p.V244A	DO8264	COAD	ICGC	RRWTLGGMV	DEG_APCC_DBOX_1	253:261	Mutation rewiring degron network	0.0833
p.D258E	DO229018	LICA	ICGC	RRWTLGGMV	DEG_APCC_DBOX_1	253:261	Mutation altering degron motif	0.6758
p.P617T	DO229009	LICA	ICGC	FRPYAE	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.1111
p.K636M	DO50753	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	645:649	Mutation rewiring degron network	0.0833
p.K636M	DO50753	LICA	ICGC	FRPYAE	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.1667
p.G255V	DO23344	LINC	ICGC	RRWTLGGMV	DEG_APCC_DBOX_1	253:261	Mutation altering degron motif	0.7532
p.G267C	DO228338	MALY	ICGC	RRWTLGGMV	DEG_APCC_DBOX_1	253:261	Mutation rewiring degron network	0.1667
p.T641M	DO32307	OV	ICGC	PGSSS	DEG_SPOP_SBC_1	645:649	Mutation rewiring degron network	0.2222
p.T641M	DO47829	STAD	ICGC	PGSSS	DEG_SPOP_SBC_1	645:649	Mutation rewiring degron network	0.2222
p.L627I	DO46657	PAAD	ICGC	FRPYAE	LIG_APCC_ABBA_1	625:630	Mutation altering degron motif	0.7174
p.D656N	DO51256	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	645:649	Mutation rewiring degron network	0.1389
p.D656N	DO51256	SKCM	ICGC	PKSSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.1389
p.D656N	DO41020	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	645:649	Mutation rewiring degron network	0.1389
p.D656N	DO41020	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.1389
p.S674P	DO231374	THCA	ICGC	PKSSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.1389
p.E633D	DO40884	UCEC	ICGC	FRPYAE	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.25
p.R615H	DO43891	UCEC	ICGC	FRPYAE	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.0556
p.R269Q	SIDM01943	Colorectal Carcinoma	GDSC	RRWTLGGMV	DEG_APCC_DBOX_1	253:261	Mutation rewiring degron network	0.1111
p.D615N	SIDM00460	B-Cell Non-Hodgkin's Lymphoma	GDSC	FRPYAE	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.0556
p.D615N	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	FRPYAE	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.0556
p.D615N	SIDM00905	Cervical Carcinoma	GDSC	FRPYAE	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.0556
p.D615N	SIDM00927	Small Cell Lung Carcinoma	GDSC	FRPYAE	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.0556
p.I668V	SIDM00781	Colorectal Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.3056
p.I668V	SIDM00655	Other Solid Cancers	GDSC	PKSSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.3056
p.I668V	SIDM00780	Colorectal Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.3056
p.I668V	SNU-C2B	large intestine	COSMIC	PKSSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.3056
p.I668V	NCCIT	testis	COSMIC	PKSSS	DEG_SPOP_SBC_1	663:667	Mutation rewiring degron network	0.3056
p.E646G	SIDM00391	Plasma Cell Myeloma	GDSC	PGSSS	DEG_SPOP_SBC_1	645:649	Mutation altering degron motif	0.7199
p.R267Q	ACH-000072	Leukemia	CCLE	RRWTLGGMV	DEG_APCC_DBOX_1	253:261	Mutation rewiring degron network	0.1667
p.R267Q	ACH-001861	Gallbladder Cancer	CCLE	RRWTLGGMV	DEG_APCC_DBOX_1	253:261	Mutation rewiring degron network	0.1667
p.R244C	ACH-000269	Brain Cancer	CCLE	RRWTLGGMV	DEG_APCC_DBOX_1	253:261	Mutation rewiring degron network	0.0833
p.G640R	ACH-000933	Pancreatic Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	645:649	Mutation rewiring degron network	0.1944
p.G640R	ACH-000933	Pancreatic Cancer	CCLE	FRPYAE	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.0556
p.R244H	ACH-000954	Endometrial/Uterine Cancer	CCLE	RRWTLGGMV	DEG_APCC_DBOX_1	253:261	Mutation rewiring degron network	0.0833
p.Y620H	ACH-000978	Endometrial/Uterine Cancer	CCLE	FRPYAE	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.1944
p.Y620H	EN	endometrium	COSMIC	FRPYAE	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.1944

Kaplan plot for SH3PXD2A in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SH3PXD2A

UniProt ID: Q5TCZ1

Entrez ID: 9644

Protein name: SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SH3PXD2A in