DegronMD

Uniprot ID: Q5TCZ1

Source protein: SH3 and PX domain-containing protein 2A

Source gene: SH3PXD2A

Class: LIG_APCC_ABBA_1

Location: 625:630

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9781

ASA_SCORE: 76.0333

COIL: 0.7253

CONS_SCORE: 0.4406

DSS_SCORE: 0.5375

HELIX: 0.1647

FCONS_SCORE: 1.1114

RIG_SCORE: 0.7616

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S619I	TCGA-77-7142	LUSC	TCGA	FRPYAE	LIG_APCC_ABBA_1	0.1667
p.S619I	DO26462	LUSC	ICGC	FRPYAE	LIG_APCC_ABBA_1	0.1667
p.K631N	DO7878	COAD	ICGC	FRPYAE	LIG_APCC_ABBA_1	0.3056
p.P617T	DO229009	LICA	ICGC	FRPYAE	LIG_APCC_ABBA_1	0.1111
p.K636M	DO50753	LICA	ICGC	FRPYAE	LIG_APCC_ABBA_1	0.1667
p.L627I	DO46657	PAAD	ICGC	FRPYAE	LIG_APCC_ABBA_1	0.7174
p.E633D	DO40884	UCEC	ICGC	FRPYAE	LIG_APCC_ABBA_1	0.25
p.R615H	DO43891	UCEC	ICGC	FRPYAE	LIG_APCC_ABBA_1	0.0556
p.D615N	SIDM00460	B-Cell Non-Hodgkin's Lymphoma	GDSC	FRPYAE	LIG_APCC_ABBA_1	0.0556
p.D615N	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	FRPYAE	LIG_APCC_ABBA_1	0.0556
p.D615N	SIDM00905	Cervical Carcinoma	GDSC	FRPYAE	LIG_APCC_ABBA_1	0.0556
p.D615N	SIDM00927	Small Cell Lung Carcinoma	GDSC	FRPYAE	LIG_APCC_ABBA_1	0.0556
p.G640R	ACH-000933	Pancreatic Cancer	CCLE	FRPYAE	LIG_APCC_ABBA_1	0.0556
p.Y620H	ACH-000978	Endometrial/Uterine Cancer	CCLE	FRPYAE	LIG_APCC_ABBA_1	0.1944
p.Y620H	EN	endometrium	COSMIC	FRPYAE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TCZ1	SH3 and PX domain-containing protein 2A	LIG_APCC_ABBA_1	625:630	FRPYAE	APC,CDC20,FZR1	0.9781	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons