DegronMD

Uniprot ID: Q5TCZ1

Source protein: SH3 and PX domain-containing protein 2A

Source gene: SH3PXD2A

Class: DEG_APCC_DBOX_1

Location: 253:261

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8066

ASA_SCORE: 82.1222

COIL: 0.6426

CONS_SCORE: 0.3334

DSS_SCORE: 0.4668

HELIX: 0.1339

FCONS_SCORE: 0.78

RIG_SCORE: 0.746

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E260Q	TCGA-C8-A12T	BRCA	TCGA	RRWTLGGMV	DEG_APCC_DBOX_1	0.6744
p.V244A	DO8264	COAD	ICGC	RRWTLGGMV	DEG_APCC_DBOX_1	0.0833
p.D258E	DO229018	LICA	ICGC	RRWTLGGMV	DEG_APCC_DBOX_1	0.6758
p.G255V	DO23344	LINC	ICGC	RRWTLGGMV	DEG_APCC_DBOX_1	0.7532
p.G267C	DO228338	MALY	ICGC	RRWTLGGMV	DEG_APCC_DBOX_1	0.1667
p.R269Q	SIDM01943	Colorectal Carcinoma	GDSC	RRWTLGGMV	DEG_APCC_DBOX_1	0.1111
p.R267Q	ACH-000072	Leukemia	CCLE	RRWTLGGMV	DEG_APCC_DBOX_1	0.1667
p.R267Q	ACH-001861	Gallbladder Cancer	CCLE	RRWTLGGMV	DEG_APCC_DBOX_1	0.1667
p.R244C	ACH-000269	Brain Cancer	CCLE	RRWTLGGMV	DEG_APCC_DBOX_1	0.0833
p.R244H	ACH-000954	Endometrial/Uterine Cancer	CCLE	RRWTLGGMV	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TCZ1	SH3 and PX domain-containing protein 2A	DEG_APCC_DBOX_1	253:261	RRWTLGGMV	APC,CDC20,FZR1	0.8066	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons