DegronMD

Uniprot ID: Q8WYP5

Source protein: Protein ELYS

Source gene: AHCTF1

Class: DEG_SPOP_SBC_1

Location: 1340:1344

E3 ligase: SPOP

DEGRON score: 0.9617

ASA_SCORE: 101.26

COIL: 0.9168

CONS_SCORE: 0.2876

DSS_SCORE: 0.5179

HELIX: 0.0518

FCONS_SCORE: 0.9638

RIG_SCORE: 0.6311

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1336L	TCGA-AJ-A3EK	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	0.2222
p.P1334A	TCGA-AR-A24Q	BRCA	TCGA	PKSSS	DEG_SPOP_SBC_1	0.1667
p.P1334L	TCGA-B5-A3FC	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	0.1667
p.A1333V	TCGA-VQ-A924	STAD	TCGA	PKSSS	DEG_SPOP_SBC_1	0.1389
p.Q1354K	DO229026	LICA	ICGC	PKSSS	DEG_SPOP_SBC_1	0.0556
p.T1336M	DO229257	THCA	ICGC	PKSSS	DEG_SPOP_SBC_1	0.2222
p.T1349I	DO43049	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.1944
p.T1354N	SIDM00799	Glioblastoma	GDSC	PKSSS	DEG_SPOP_SBC_1	0.0556
p.T1354N	A172	central_nervous_system	COSMIC	PKSSS	DEG_SPOP_SBC_1	0.0556
p.E1353G	ACH-000978	Endometrial/Uterine Cancer	CCLE	PKSSS	DEG_SPOP_SBC_1	0.0833
p.S1349C	LS-513	large_intestine	COSMIC	PKSSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15085	Rho guanine nucleotide exchange factor 11	DEG_SPOP_SBC_1	543:547	PKSSS	SPOP	0.7465	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1015:1019	PKSSS	SPOP	0.8719	More...
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	564:568	PKSSS	SPOP	0.9922	More...
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	289:293	PKSSS	SPOP	0.9956	More...
Q15811	Intersectin-1	DEG_SPOP_SBC_1	180:184	PKSSS	SPOP	0.9976	More...
Q5T200	Zinc finger CCCH domain-containing protein 13	DEG_SPOP_SBC_1	225:229	PKSSS	SPOP	0.9834	More...
Q5TCZ1	SH3 and PX domain-containing protein 2A	DEG_SPOP_SBC_1	663:667	PKSSS	SPOP	0.8452	More...
Q6DN12	Multiple C2 and transmembrane domain-containing protein 2	DEG_SPOP_SBC_1	89:93	PKSSS	SPOP	0.7468	More...
Q7L590	Protein MCM10 homolog	DEG_SPOP_SBC_1	200:204	PKSSS	SPOP	0.9805	More...
Q8N3F8	MICAL-like protein 1	DEG_SPOP_SBC_1	534:538	PKSSS	SPOP	0.9952	More...
Q8WYP5	Protein ELYS	DEG_SPOP_SBC_1	1340:1344	PKSSS	SPOP	0.9617	More...
Q96QS3	Homeobox protein ARX	DEG_SPOP_SBC_1	68:72	PKSSS	SPOP	0.583	More...
Q9NXV6	CDKN2A-interacting protein	DEG_SPOP_SBC_1	347:351	PKSSS	SPOP	0.9905	More...
Q9Y2I7	1-phosphatidylinositol 3-phosphate 5-kinase	DEG_SPOP_SBC_1	1710:1714	PKSSS	SPOP	0.9961	More...
Q9Y5X1	Sorting nexin-9	DEG_SPOP_SBC_1	172:176	PKSSS	SPOP	0.9854	More...
A6NHQ2	rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1	DEG_SPOP_SBC_1	329:333	PKSSS	SPOP	0.72	More...
A7E2F4	Golgin subfamily A member 8A	DEG_SPOP_SBC_1	83:87	PKSSS	SPOP	0.7895	More...
Q5H9T9	Fibrous sheath CABYR-binding protein	DEG_SPOP_SBC_1	20:24	PKSSS	SPOP	0.8424	More...
Q5JSZ5	Protein PRRC2B	DEG_SPOP_SBC_1	96:100	PKSSS	SPOP	0.8516	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	544:548	PKSSS	SPOP	0.9953	More...
Q9BX69	Caspase recruitment domain-containing protein 6	DEG_SPOP_SBC_1	1012:1016	PKSSS	SPOP	0.9263	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	434:438	PKSSS	SPOP	0.9775	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKSSS

Degron related mutations and impact score

Drug responses associated with AHCTF1 mutations

All proteins holding degron of PKSSS