DegronMD - Q8WYP5(AHCTF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1656R	TCGA-13-1481	OV	TCGA	DTLPYVPEP	DEG_COP1_1	1655:1663	Mutation altering degron motif	0.7427
p.A1222P	TCGA-49-4488	LUAD	TCGA	LRSTPLAS	DEG_SCF_FBW7_1	1207:1214	Mutation blocking phosphorylation signal	0.5556
p.S1656I	TCGA-55-7994	LUAD	TCGA	DTLPYVPEP	DEG_COP1_1	1655:1663	Mutation altering degron motif	0.7341
p.S1656C	TCGA-55-7994	LUAD	TCGA	DTLPYVPEP	DEG_COP1_1	1655:1663	Mutation altering degron motif	0.7541
p.A1653V	TCGA-77-A5G3	LUSC	TCGA	DTLPYVPEP	DEG_COP1_1	1655:1663	Mutation blocking ubiquitination signal	0.7222
p.D1657G	TCGA-85-8582	LUSC	TCGA	DTLPYVPEP	DEG_COP1_1	1655:1663	Mutation altering degron motif	0.7198
p.L1216V	TCGA-AC-A23H	BRCA	TCGA	LRSTPLAS	DEG_SCF_FBW7_1	1207:1214	Mutation blocking phosphorylation signal	0.7222
p.P1336L	TCGA-AJ-A3EK	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	1340:1344	Mutation rewiring degron network	0.2222
p.P1334A	TCGA-AR-A24Q	BRCA	TCGA	PKSSS	DEG_SPOP_SBC_1	1340:1344	Mutation rewiring degron network	0.1667
p.S1197T	TCGA-B5-A11G	UCEC	TCGA	LRSTPLAS	DEG_SCF_FBW7_1	1207:1214	Mutation rewiring degron network	0.0556
p.P1334L	TCGA-B5-A3FC	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	1340:1344	Mutation rewiring degron network	0.1667
p.S1214F	TCGA-DD-AACJ	LIHC	TCGA	LRSTPLAS	DEG_SCF_FBW7_1	1207:1214	Mutation altering degron motif	0.9093
p.A1333V	TCGA-VQ-A924	STAD	TCGA	PKSSS	DEG_SPOP_SBC_1	1340:1344	Mutation rewiring degron network	0.1389
p.S1216Y	DO444	BLCA	ICGC	LRSTPLAS	DEG_SCF_FBW7_1	1207:1214	Mutation blocking phosphorylation signal	0.7222
p.L1207V	DO2401	BRCA	ICGC	LRSTPLAS	DEG_SCF_FBW7_1	1207:1214	Mutation altering degron motif	0.5654
p.T1656A	DO52450	COCA	ICGC	DTLPYVPEP	DEG_COP1_1	1655:1663	Mutation altering degron motif	0.825
p.Q1354K	DO229026	LICA	ICGC	PKSSS	DEG_SPOP_SBC_1	1340:1344	Mutation rewiring degron network	0.0556
p.S1205F	DO52206	LIHC	ICGC	LRSTPLAS	DEG_SCF_FBW7_1	1207:1214	Mutation blocking phosphorylation signal	0.7222
p.S1647I	DO45311	LUAD	ICGC	DTLPYVPEP	DEG_COP1_1	1655:1663	Mutation blocking phosphorylation signal	0.5556
p.S1647C	DO45311	LUAD	ICGC	DTLPYVPEP	DEG_COP1_1	1655:1663	Mutation blocking phosphorylation signal	0.5556
p.A1213P	DO24750	LUAD	ICGC	LRSTPLAS	DEG_SCF_FBW7_1	1207:1214	Mutation altering degron motif	0.6392
p.P1223L	DO231124	LUSC	ICGC	LRSTPLAS	DEG_SCF_FBW7_1	1207:1214	Mutation rewiring degron network	0.0833
p.P1223L	DO47903	STAD	ICGC	LRSTPLAS	DEG_SCF_FBW7_1	1207:1214	Mutation rewiring degron network	0.0833
p.D1648G	DO45491	LUSC	ICGC	DTLPYVPEP	DEG_COP1_1	1655:1663	Mutation rewiring degron network	0.1389
p.S1647R	DO31789	OV	ICGC	DTLPYVPEP	DEG_COP1_1	1655:1663	Mutation blocking phosphorylation signal	0.5556
p.P1217S	DO51290	SKCM	ICGC	LRSTPLAS	DEG_SCF_FBW7_1	1207:1214	Mutation rewiring degron network	0.25
p.T1336M	DO229257	THCA	ICGC	PKSSS	DEG_SPOP_SBC_1	1340:1344	Mutation rewiring degron network	0.2222
p.T1349I	DO43049	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	1340:1344	Mutation rewiring degron network	0.1944
p.T1354N	SIDM00799	Glioblastoma	GDSC	PKSSS	DEG_SPOP_SBC_1	1340:1344	Mutation rewiring degron network	0.0556
p.T1354N	A172	central nervous system	COSMIC	PKSSS	DEG_SPOP_SBC_1	1340:1344	Mutation rewiring degron network	0.0556
p.P1651Q	SIDM00482	Chronic Myelogenous Leukemia	GDSC	DTLPYVPEP	DEG_COP1_1	1655:1663	Mutation rewiring degron network	0.2222
p.P1651Q	RPMI-8866	haematopoietic and lymphoid tissue	COSMIC	DTLPYVPEP	DEG_COP1_1	1655:1663	Mutation rewiring degron network	0.2222
p.Q1646K	SIDM01378	Ovarian Carcinoma	GDSC	DTLPYVPEP	DEG_COP1_1	1655:1663	Mutation rewiring degron network	0.0833
p.Q1672K	ACH-000646	Ovarian Cancer	CCLE	DTLPYVPEP	DEG_COP1_1	1655:1663	Mutation rewiring degron network	0.0833
p.A1221V	ACH-000959	Colon/Colorectal Cancer	CCLE	LRSTPLAS	DEG_SCF_FBW7_1	1207:1214	Mutation rewiring degron network	0.1389
p.E1353G	ACH-000978	Endometrial/Uterine Cancer	CCLE	PKSSS	DEG_SPOP_SBC_1	1340:1344	Mutation rewiring degron network	0.0833
p.G1665V	NCI-H322M	lung	COSMIC	DTLPYVPEP	DEG_COP1_1	1655:1663	Mutation blocking ubiquitination signal	0.7222
p.S1349C	LS-513	large intestine	COSMIC	PKSSS	DEG_SPOP_SBC_1	1340:1344	Mutation rewiring degron network	0.1944

Kaplan plot for AHCTF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AHCTF1

UniProt ID: Q8WYP5

Entrez ID: 25909

Protein name: Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AHCTF1 in