DegronMD

Uniprot ID: Q8WYP5

Source protein: Protein ELYS

Source gene: AHCTF1

Class: DEG_SCF_FBW7_1

Location: 1207:1214

E3 ligase: FBXW7

DEGRON score: 0.9978

ASA_SCORE: 99.8

COIL: 0.9566

CONS_SCORE: 0.4337

DSS_SCORE: 0.6466

HELIX: 0.0185

FCONS_SCORE: 1.0228

RIG_SCORE: 0.6401

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1222P	TCGA-49-4488	LUAD	TCGA	LRSTPLAS	DEG_SCF_FBW7_1	0.5556
p.L1216V	TCGA-AC-A23H	BRCA	TCGA	LRSTPLAS	DEG_SCF_FBW7_1	0.7222
p.S1197T	TCGA-B5-A11G	UCEC	TCGA	LRSTPLAS	DEG_SCF_FBW7_1	0.0556
p.S1214F	TCGA-DD-AACJ	LIHC	TCGA	LRSTPLAS	DEG_SCF_FBW7_1	0.9093
p.S1216Y	DO444	BLCA	ICGC	LRSTPLAS	DEG_SCF_FBW7_1	0.7222
p.L1207V	DO2401	BRCA	ICGC	LRSTPLAS	DEG_SCF_FBW7_1	0.5654
p.S1205F	DO52206	LIHC	ICGC	LRSTPLAS	DEG_SCF_FBW7_1	0.7222
p.A1213P	DO24750	LUAD	ICGC	LRSTPLAS	DEG_SCF_FBW7_1	0.6392
p.P1223L	DO231124	LUSC	ICGC	LRSTPLAS	DEG_SCF_FBW7_1	0.0833
p.P1223L	DO47903	STAD	ICGC	LRSTPLAS	DEG_SCF_FBW7_1	0.0833
p.P1217S	DO51290	SKCM	ICGC	LRSTPLAS	DEG_SCF_FBW7_1	0.25
p.A1221V	ACH-000959	Colon/Colorectal Cancer	CCLE	LRSTPLAS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WYP5	Protein ELYS	DEG_SCF_FBW7_1	1207:1214	LRSTPLAS	FBXW7	0.9978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons