DegronMD

Uniprot ID: Q8WYP5

Source protein: Protein ELYS

Source gene: AHCTF1

Class: DEG_COP1_1

Location: 1655:1663

E3 ligase: COP1

DEGRON score: 0.9984

ASA_SCORE: 100.4333

COIL: 0.9244

CONS_SCORE: 0.346

DSS_SCORE: 0.364

HELIX: 0.0169

FCONS_SCORE: 1.1046

RIG_SCORE: 0.7993

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1656R	TCGA-13-1481	OV	TCGA	DTLPYVPEP	DEG_COP1_1	0.7427
p.S1656I	TCGA-55-7994	LUAD	TCGA	DTLPYVPEP	DEG_COP1_1	0.7341
p.S1656C	TCGA-55-7994	LUAD	TCGA	DTLPYVPEP	DEG_COP1_1	0.7541
p.A1653V	TCGA-77-A5G3	LUSC	TCGA	DTLPYVPEP	DEG_COP1_1	0.7222
p.D1657G	TCGA-85-8582	LUSC	TCGA	DTLPYVPEP	DEG_COP1_1	0.7198
p.T1656A	DO52450	COCA	ICGC	DTLPYVPEP	DEG_COP1_1	0.825
p.S1647I	DO45311	LUAD	ICGC	DTLPYVPEP	DEG_COP1_1	0.5556
p.S1647C	DO45311	LUAD	ICGC	DTLPYVPEP	DEG_COP1_1	0.5556
p.D1648G	DO45491	LUSC	ICGC	DTLPYVPEP	DEG_COP1_1	0.1389
p.S1647R	DO31789	OV	ICGC	DTLPYVPEP	DEG_COP1_1	0.5556
p.P1651Q	SIDM00482	Chronic Myelogenous Leukemia	GDSC	DTLPYVPEP	DEG_COP1_1	0.2222
p.P1651Q	RPMI-8866	haematopoietic_and_lymphoid_tissue	COSMIC	DTLPYVPEP	DEG_COP1_1	0.2222
p.Q1646K	SIDM01378	Ovarian Carcinoma	GDSC	DTLPYVPEP	DEG_COP1_1	0.0833
p.Q1672K	ACH-000646	Ovarian Cancer	CCLE	DTLPYVPEP	DEG_COP1_1	0.0833
p.G1665V	NCI-H322M	lung	COSMIC	DTLPYVPEP	DEG_COP1_1	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WYP5	Protein ELYS	DEG_COP1_1	1655:1663	DTLPYVPEP	COP1	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons