DegronMD

Uniprot ID: Q5H9T9

Source protein: Fibrous sheath CABYR-binding protein

Source gene: FSCB

Class: DEG_SCF_FBW7_2

Location: 446:452

E3 ligase: FBXW7

DEGRON score: 0.7326

ASA_SCORE: 109.5714

COIL: 0.9234

CONS_SCORE: 0.4959

DSS_SCORE: 0.7616

HELIX: 0.0506

FCONS_SCORE: 0.919

RIG_SCORE: 0.6423

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M446I	TCGA-05-4432	LUAD	TCGA	METPAEE	DEG_SCF_FBW7_2	0.6507
p.M446I	DO25995	LUAD	ICGC	METPAEE	DEG_SCF_FBW7_2	0.6507
p.E447V	TCGA-13-0911	OV	TCGA	METPAEE	DEG_SCF_FBW7_2	0.6582
p.E447V	DO31553	OV	ICGC	METPAEE	DEG_SCF_FBW7_2	0.6582
p.A453S	TCGA-17-Z058	LUAD	TCGA	METPAEE	DEG_SCF_FBW7_2	0.3056
p.E452D	TCGA-17-Z058	LUAD	TCGA	METPAEE	DEG_SCF_FBW7_2	0.6758
p.E452D	SIDM00282	Colorectal Carcinoma	GDSC	METPAEE	DEG_SCF_FBW7_2	0.6758
p.E452D	ACH-000998	Colon/Colorectal Cancer	CCLE	METPAEE	DEG_SCF_FBW7_2	0.6758
p.E452D	CW-2	large_intestine	COSMIC	METPAEE	DEG_SCF_FBW7_2	0.6758
p.T455N	TCGA-55-A493	LUAD	TCGA	METPAEE	DEG_SCF_FBW7_2	0.25
p.T455N	DO26328	LUAD	ICGC	METPAEE	DEG_SCF_FBW7_2	0.25
p.R438Q	TCGA-AD-A5EK	COAD	TCGA	METPAEE	DEG_SCF_FBW7_2	0.1111
p.R438Q	DO44089	COAD	ICGC	METPAEE	DEG_SCF_FBW7_2	0.1111
p.P462H	TCGA-FS-A1ZG	SKCM	TCGA	METPAEE	DEG_SCF_FBW7_2	0.0556
p.P462H	TCGA-GL-6846	KIRP	TCGA	METPAEE	DEG_SCF_FBW7_2	0.0556
p.P462H	DO20808	KIRP	ICGC	METPAEE	DEG_SCF_FBW7_2	0.0556
p.P462H	DO37523	SKCM	ICGC	METPAEE	DEG_SCF_FBW7_2	0.0556
p.L440R	TCGA-IC-A6RE	ESCA	TCGA	METPAEE	DEG_SCF_FBW7_2	0.1667
p.E456Q	DO223560	CLLE	ICGC	METPAEE	DEG_SCF_FBW7_2	0.2222
p.T444K	DO229037	LICA	ICGC	METPAEE	DEG_SCF_FBW7_2	0.2778
p.P454L	DO229275	THCA	ICGC	METPAEE	DEG_SCF_FBW7_2	0.2778
p.A450V	DO229221	THCA	ICGC	METPAEE	DEG_SCF_FBW7_2	0.5825
p.R438G	SIDM00672	Hepatocellular Carcinoma	GDSC	METPAEE	DEG_SCF_FBW7_2	0.1111
p.R438G	SIDM00254	Neuroblastoma	GDSC	METPAEE	DEG_SCF_FBW7_2	0.1111
p.R438G	SIDM00875	Breast Carcinoma	GDSC	METPAEE	DEG_SCF_FBW7_2	0.1111
p.R438G	SIDM00954	Breast Carcinoma	GDSC	METPAEE	DEG_SCF_FBW7_2	0.1111
p.Q458E	SIDM00025	Head and Neck Carcinoma	GDSC	METPAEE	DEG_SCF_FBW7_2	0.1667
p.Q458E	ACH-002391	Head and Neck Cancer	CCLE	METPAEE	DEG_SCF_FBW7_2	0.1667
p.Q458E	UDSCC2	upper_aerodigestive_tract	COSMIC	METPAEE	DEG_SCF_FBW7_2	0.1667
p.E436D	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	METPAEE	DEG_SCF_FBW7_2	0.0556
p.E436D	ACH-000852	Lung Cancer	CCLE	METPAEE	DEG_SCF_FBW7_2	0.0556
p.E436D	NCI-H1435	lung	COSMIC	METPAEE	DEG_SCF_FBW7_2	0.0556
p.S459P	SIDM01378	Ovarian Carcinoma	GDSC	METPAEE	DEG_SCF_FBW7_2	0.1389
p.S459P	ACH-000646	Ovarian Cancer	CCLE	METPAEE	DEG_SCF_FBW7_2	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: METPAEE

Degron related mutations and impact score

Drug responses associated with FSCB mutations

All proteins holding degron of METPAEE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5H9T9	Fibrous sheath CABYR-binding protein	DEG_SCF_FBW7_2	446:452	METPAEE	FBXW7	0.7326	More...