DegronMD

Uniprot ID: Q5H9T9

Source protein: Fibrous sheath CABYR-binding protein

Source gene: FSCB

Class: DEG_SCF_FBW7_2

Location: 446:452

E3 ligase: FBXW7

DEGRON score: 0.7326

ASA_SCORE: 109.5714

COIL: 0.9234

CONS_SCORE: 0.4959

DSS_SCORE: 0.7616

HELIX: 0.0506

FCONS_SCORE: 0.919

RIG_SCORE: 0.6423

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E452D	TCGA-17-Z058	LUAD	TCGA	METPAEE	DEG_SCF_FBW7_2	0.6758
p.E452D	SIDM00282	Colorectal Carcinoma	GDSC	METPAEE	DEG_SCF_FBW7_2	0.6758
p.E452D	ACH-000998	Colon/Colorectal Cancer	CCLE	METPAEE	DEG_SCF_FBW7_2	0.6758
p.E452D	CW-2	large_intestine	COSMIC	METPAEE	DEG_SCF_FBW7_2	0.6758
p.E447V	TCGA-13-0911	OV	TCGA	METPAEE	DEG_SCF_FBW7_2	0.6582
p.E447V	DO31553	OV	ICGC	METPAEE	DEG_SCF_FBW7_2	0.6582
p.M446I	TCGA-05-4432	LUAD	TCGA	METPAEE	DEG_SCF_FBW7_2	0.6507
p.M446I	DO25995	LUAD	ICGC	METPAEE	DEG_SCF_FBW7_2	0.6507
p.A450V	DO229221	THCA	ICGC	METPAEE	DEG_SCF_FBW7_2	0.5825
p.A453S	TCGA-17-Z058	LUAD	TCGA	METPAEE	DEG_SCF_FBW7_2	0.3056
p.T444K	DO229037	LICA	ICGC	METPAEE	DEG_SCF_FBW7_2	0.2778
p.P454L	DO229275	THCA	ICGC	METPAEE	DEG_SCF_FBW7_2	0.2778
p.T455N	TCGA-55-A493	LUAD	TCGA	METPAEE	DEG_SCF_FBW7_2	0.25
p.T455N	DO26328	LUAD	ICGC	METPAEE	DEG_SCF_FBW7_2	0.25
p.E456Q	DO223560	CLLE	ICGC	METPAEE	DEG_SCF_FBW7_2	0.2222
p.L440R	TCGA-IC-A6RE	ESCA	TCGA	METPAEE	DEG_SCF_FBW7_2	0.1667
p.Q458E	SIDM00025	Head and Neck Carcinoma	GDSC	METPAEE	DEG_SCF_FBW7_2	0.1667
p.Q458E	ACH-002391	Head and Neck Cancer	CCLE	METPAEE	DEG_SCF_FBW7_2	0.1667
p.Q458E	UDSCC2	upper_aerodigestive_tract	COSMIC	METPAEE	DEG_SCF_FBW7_2	0.1667
p.S459P	SIDM01378	Ovarian Carcinoma	GDSC	METPAEE	DEG_SCF_FBW7_2	0.1389
p.S459P	ACH-000646	Ovarian Cancer	CCLE	METPAEE	DEG_SCF_FBW7_2	0.1389
p.R438Q	TCGA-AD-A5EK	COAD	TCGA	METPAEE	DEG_SCF_FBW7_2	0.1111
p.R438Q	DO44089	COAD	ICGC	METPAEE	DEG_SCF_FBW7_2	0.1111
p.R438G	SIDM00672	Hepatocellular Carcinoma	GDSC	METPAEE	DEG_SCF_FBW7_2	0.1111
p.R438G	SIDM00254	Neuroblastoma	GDSC	METPAEE	DEG_SCF_FBW7_2	0.1111

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Drug responses associated with FSCB mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of METPAEE

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5H9T9	Fibrous sheath CABYR-binding protein	DEG_SCF_FBW7_2	446:452	METPAEE	FBXW7	0.7326	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: METPAEE

Degron related mutations and impact score

Drug responses associated with FSCB mutations

All proteins holding degron of METPAEE