DegronMD - Q9BWT3(PAPOLG)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G653V	TCGA-A2-A25A	BRCA	TCGA	VTPKRS	DEG_SCF_FBW7_1	641:646	Mutation rewiring degron network	0.1389
p.G653V	DO3101	BRCA	ICGC	VTPKRS	DEG_SCF_FBW7_1	641:646	Mutation rewiring degron network	0.1389
p.D713N	TCGA-A5-A0G2	UCEC	TCGA	PDSSS	DEG_SPOP_SBC_1	712:716	Mutation altering degron motif	0.5821
p.D713N	DO41235	UCEC	ICGC	PDSSS	DEG_SPOP_SBC_1	712:716	Mutation altering degron motif	0.5821
p.P655L	TCGA-AF-5654	READ	TCGA	VTPKRS	DEG_SCF_FBW7_1	641:646	Mutation rewiring degron network	0.0833
p.P655L	DO36647	READ	ICGC	VTPKRS	DEG_SCF_FBW7_1	641:646	Mutation rewiring degron network	0.0833
p.S650Y	TCGA-AX-A1CE	UCEC	TCGA	VTPKRS	DEG_SCF_FBW7_1	641:646	Mutation blocking phosphorylation signal	0.6667
p.S650Y	DO42280	UCEC	ICGC	VTPKRS	DEG_SCF_FBW7_1	641:646	Mutation blocking phosphorylation signal	0.6667
p.R702C	TCGA-BR-4280	STAD	TCGA	PDSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.0556
p.R702C	DO233089	GACA	ICGC	PDSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.0556
p.R702C	DO38663	STAD	ICGC	PDSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.0556
p.P717L	TCGA-ER-A42L	SKCM	TCGA	PDSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.3056
p.P717L	DO223910	SKCM	ICGC	PDSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.3056
p.T642I	DO227802	COCA	ICGC	VTPKRS	DEG_SCF_FBW7_1	641:646	Mutation altering degron motif	0.7078
p.P717A	DO227994	COCA	ICGC	PDSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.3056
p.R724L	DO228971	LICA	ICGC	PDSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.1111
p.V718F	DO229018	LICA	ICGC	PDSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.2778
p.R702L	DO229019	LICA	ICGC	PDSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.0556
p.D713Y	DO229032	LICA	ICGC	PDSSS	DEG_SPOP_SBC_1	712:716	Mutation altering degron motif	0.6214
p.S708I	DO229052	LICA	ICGC	PDSSS	DEG_SPOP_SBC_1	712:716	Mutation blocking phosphorylation signal	0.6667
p.T642R	SIDM01036	Plasma Cell Myeloma	GDSC	VTPKRS	DEG_SCF_FBW7_1	641:646	Mutation altering degron motif	0.7876
p.T642R	SIDM00998	Glioblastoma	GDSC	VTPKRS	DEG_SCF_FBW7_1	641:646	Mutation altering degron motif	0.7876
p.T642R	JJN-3	haematopoietic and lymphoid tissue	COSMIC	VTPKRS	DEG_SCF_FBW7_1	641:646	Mutation altering degron motif	0.7876
p.M634K	SIDM01138	Pancreatic Carcinoma	GDSC	VTPKRS	DEG_SCF_FBW7_1	641:646	Mutation rewiring degron network	0.1389
p.M634K	ACH-000139	Pancreatic Cancer	CCLE	VTPKRS	DEG_SCF_FBW7_1	641:646	Mutation rewiring degron network	0.1389
p.M634K	PANC-03-27	pancreas	COSMIC	VTPKRS	DEG_SCF_FBW7_1	641:646	Mutation rewiring degron network	0.1389
p.R702H	SIDM01439	Hepatocellular Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.0556
p.R702H	ACH-000537	Liver Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.0556
p.N721S	SIDM01612	Endometrial Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.1944
p.N721S	ACH-000946	Endometrial/Uterine Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	712:716	Mutation rewiring degron network	0.1944
p.K639E	ACH-002027	Endometrial/Uterine Cancer	CCLE	VTPKRS	DEG_SCF_FBW7_1	641:646	Mutation rewiring degron network	0.2778
p.K644T	BCPAP	thyroid	COSMIC	VTPKRS	DEG_SCF_FBW7_1	641:646	Mutation altering degron motif	0.6195

Kaplan plot for PAPOLG in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PAPOLG

UniProt ID: Q9BWT3

Entrez ID: 64895

Protein name: Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PAPOLG in