DegronMD

Uniprot ID: Q9BWT3

Source protein: Poly

Source gene: PAPOLG

Class: DEG_SCF_FBW7_1

Location: 641:646

E3 ligase: FBXW7

DEGRON score: 0.9655

ASA_SCORE: 103.4

COIL: 0.9315

CONS_SCORE: 0.1395

DSS_SCORE: 0.682

HELIX: 0.0187

FCONS_SCORE: 0.8733

RIG_SCORE: 0.644

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G653V	TCGA-A2-A25A	BRCA	TCGA	VTPKRS	DEG_SCF_FBW7_1	0.1389
p.G653V	DO3101	BRCA	ICGC	VTPKRS	DEG_SCF_FBW7_1	0.1389
p.P655L	TCGA-AF-5654	READ	TCGA	VTPKRS	DEG_SCF_FBW7_1	0.0833
p.P655L	DO36647	READ	ICGC	VTPKRS	DEG_SCF_FBW7_1	0.0833
p.S650Y	TCGA-AX-A1CE	UCEC	TCGA	VTPKRS	DEG_SCF_FBW7_1	0.6667
p.S650Y	DO42280	UCEC	ICGC	VTPKRS	DEG_SCF_FBW7_1	0.6667
p.T642I	DO227802	COCA	ICGC	VTPKRS	DEG_SCF_FBW7_1	0.7078
p.T642R	SIDM01036	Plasma Cell Myeloma	GDSC	VTPKRS	DEG_SCF_FBW7_1	0.7876
p.T642R	SIDM00998	Glioblastoma	GDSC	VTPKRS	DEG_SCF_FBW7_1	0.7876
p.T642R	JJN-3	haematopoietic_and_lymphoid_tissue	COSMIC	VTPKRS	DEG_SCF_FBW7_1	0.7876
p.M634K	SIDM01138	Pancreatic Carcinoma	GDSC	VTPKRS	DEG_SCF_FBW7_1	0.1389
p.M634K	ACH-000139	Pancreatic Cancer	CCLE	VTPKRS	DEG_SCF_FBW7_1	0.1389
p.M634K	PANC-03-27	pancreas	COSMIC	VTPKRS	DEG_SCF_FBW7_1	0.1389
p.K639E	ACH-002027	Endometrial/Uterine Cancer	CCLE	VTPKRS	DEG_SCF_FBW7_1	0.2778
p.K644T	BCPAP	thyroid	COSMIC	VTPKRS	DEG_SCF_FBW7_1	0.6195

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BWT3	Poly	DEG_SCF_FBW7_1	641:646	VTPKRS	FBXW7	0.9655	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons