DegronMD - Q9UPT6(MAPK8IP3)

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E893K	TCGA-46-6025	LUSC	TCGA	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation altering degron motif	0.7022
p.E893K	TCGA-55-A493	LUAD	TCGA	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation altering degron motif	0.7022
p.P904H	TCGA-55-6979	LUAD	TCGA	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation altering degron motif	0.7694
p.Y298C	TCGA-85-8582	LUSC	TCGA	VPSAAVTPL	DEG_SIAH_1	280:288	Mutation rewiring degron network	0.0556
p.Y298C	DO8858	COAD	ICGC	VPSAAVTPL	DEG_SIAH_1	280:288	Mutation rewiring degron network	0.0556
p.Y298C	DO45491	LUSC	ICGC	VPSAAVTPL	DEG_SIAH_1	280:288	Mutation rewiring degron network	0.0556
p.A284T	TCGA-CG-5721	STAD	TCGA	VPSAAVTPL	DEG_SIAH_1	280:288	Mutation altering degron motif	0.6028
p.A284T	DO38192	STAD	ICGC	VPSAAVTPL	DEG_SIAH_1	280:288	Mutation altering degron motif	0.6028
p.A284T	ACH-001610	Brain Cancer	CCLE	VPSAAVTPL	DEG_SIAH_1	280:288	Mutation altering degron motif	0.6028
p.S282L	TCGA-CV-6961	HNSC	TCGA	TPTSSVPSA	DEG_COP1_1	275:283	Mutation altering degron motif	0.7667
p.S282L	TCGA-CV-6961	HNSC	TCGA	VPSAAVTPL	DEG_SIAH_1	280:288	Mutation altering degron motif	0.6556
p.S282L	TCGA-EK-A3GK	CESC	TCGA	TPTSSVPSA	DEG_COP1_1	275:283	Mutation altering degron motif	0.7667
p.S282L	TCGA-EK-A3GK	CESC	TCGA	VPSAAVTPL	DEG_SIAH_1	280:288	Mutation altering degron motif	0.6556
p.S282L	DO49964	CESC	ICGC	TPTSSVPSA	DEG_COP1_1	275:283	Mutation altering degron motif	0.7667
p.S282L	DO49964	CESC	ICGC	VPSAAVTPL	DEG_SIAH_1	280:288	Mutation altering degron motif	0.6556
p.S282L	DO14566	HNSC	ICGC	TPTSSVPSA	DEG_COP1_1	275:283	Mutation altering degron motif	0.7667
p.S282L	DO14566	HNSC	ICGC	VPSAAVTPL	DEG_SIAH_1	280:288	Mutation altering degron motif	0.6556
p.S282L	ACH-000913	Endometrial/Uterine Cancer	CCLE	TPTSSVPSA	DEG_COP1_1	275:283	Mutation altering degron motif	0.7667
p.S282L	ACH-000913	Endometrial/Uterine Cancer	CCLE	VPSAAVTPL	DEG_SIAH_1	280:288	Mutation altering degron motif	0.6556
p.S282L	ACH-002288	Embryonal Cancer	CCLE	TPTSSVPSA	DEG_COP1_1	275:283	Mutation altering degron motif	0.7667
p.S282L	ACH-002288	Embryonal Cancer	CCLE	VPSAAVTPL	DEG_SIAH_1	280:288	Mutation altering degron motif	0.6556
p.S282L	ESS-1	endometrium	COSMIC	TPTSSVPSA	DEG_COP1_1	275:283	Mutation altering degron motif	0.7667
p.S282L	ESS-1	endometrium	COSMIC	VPSAAVTPL	DEG_SIAH_1	280:288	Mutation altering degron motif	0.6556
p.S282L	NEC8	testis	COSMIC	TPTSSVPSA	DEG_COP1_1	275:283	Mutation altering degron motif	0.7667
p.S282L	NEC8	testis	COSMIC	VPSAAVTPL	DEG_SIAH_1	280:288	Mutation altering degron motif	0.6556
p.P906R	TCGA-DD-A1EE	LIHC	TCGA	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation rewiring degron network	0.2778
p.A283T	TCGA-DU-6392	LGG	TCGA	TPTSSVPSA	DEG_COP1_1	275:283	Mutation altering degron motif	0.7139
p.A283T	TCGA-DU-6392	LGG	TCGA	VPSAAVTPL	DEG_SIAH_1	280:288	Mutation altering degron motif	0.7139
p.A283T	DO22237	LGG	ICGC	TPTSSVPSA	DEG_COP1_1	275:283	Mutation altering degron motif	0.7139
p.A283T	DO22237	LGG	ICGC	VPSAAVTPL	DEG_SIAH_1	280:288	Mutation altering degron motif	0.7139
p.P935R	TCGA-EB-A4P0	SKCM	TCGA	PDSSS	DEG_SPOP_SBC_1	945:949	Mutation rewiring degron network	0.0556
p.G884W	TCGA-EE-A29Q	SKCM	TCGA	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation rewiring degron network	0.1111
p.P888L	TCGA-QC-A7B5	SARC	TCGA	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation rewiring degron network	0.2222
p.S278F	TCGA-W3-A824	SKCM	TCGA	TPTSSVPSA	DEG_COP1_1	275:283	Mutation altering degron motif	0.6871
p.S278F	DO51271	SKCM	ICGC	TPTSSVPSA	DEG_COP1_1	275:283	Mutation altering degron motif	0.6871
p.R909W	DO223732	CESC	ICGC	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation rewiring degron network	0.1944
p.R909W	DO223703	COAD	ICGC	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation rewiring degron network	0.1944
p.T955S	DO6329	CESC	ICGC	PDSSS	DEG_SPOP_SBC_1	945:949	Mutation rewiring degron network	0.1667
p.V285I	DO222790	COCA	ICGC	VPSAAVTPL	DEG_SIAH_1	280:288	Mutation altering degron motif	0.7076
p.R909Q	DO50346	ESAD	ICGC	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation rewiring degron network	0.1944
p.R909Q	DO52674	MALY	ICGC	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation rewiring degron network	0.1944
p.R909Q	MV-4-11	haematopoietic and lymphoid tissue	COSMIC	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation rewiring degron network	0.1944
p.E902K	DO234226	ESAD	ICGC	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation altering degron motif	0.7022
p.E902K	DO229462	SKCA	ICGC	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation altering degron motif	0.7022
p.T275M	DO233731	GACA	ICGC	TPTSSVPSA	DEG_COP1_1	275:283	Mutation altering degron motif	0.7423
p.P900R	DO22857	LIHC	ICGC	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation altering degron motif	0.7512
p.T905I	DO23290	LINC	ICGC	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation rewiring degron network	0.3056
p.P898H	DO24110	LUAD	ICGC	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation altering degron motif	0.7694
p.E887K	DO26328	LUAD	ICGC	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation rewiring degron network	0.1944
p.E887K	DO26644	LUSC	ICGC	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation rewiring degron network	0.1944
p.P882L	DO220239	SARC	ICGC	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation rewiring degron network	0.0556
p.G911E	DO219468	SKCM	ICGC	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation rewiring degron network	0.1389
p.G911R	DO40889	UCEC	ICGC	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation rewiring degron network	0.1389
p.S283L	SIDM01043	Other Sarcomas	GDSC	TPTSSVPSA	DEG_COP1_1	275:283	Mutation altering degron motif	0.7667
p.S283L	SIDM01043	Other Sarcomas	GDSC	VPSAAVTPL	DEG_SIAH_1	280:288	Mutation altering degron motif	0.7667
p.S283L	SIDM00243	Other Solid Cancers	GDSC	TPTSSVPSA	DEG_COP1_1	275:283	Mutation altering degron motif	0.7667
p.S283L	SIDM00243	Other Solid Cancers	GDSC	VPSAAVTPL	DEG_SIAH_1	280:288	Mutation altering degron motif	0.7667
p.S283L	ESS-1	endometrium	COSMIC	TPTSSVPSA	DEG_COP1_1	275:283	Mutation altering degron motif	0.7667
p.S283L	ESS-1	endometrium	COSMIC	VPSAAVTPL	DEG_SIAH_1	280:288	Mutation altering degron motif	0.7667
p.S283L	NEC8	testis	COSMIC	TPTSSVPSA	DEG_COP1_1	275:283	Mutation altering degron motif	0.7667
p.S283L	NEC8	testis	COSMIC	VPSAAVTPL	DEG_SIAH_1	280:288	Mutation altering degron motif	0.7667
p.N942K	SIDM00633	Breast Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	945:949	Mutation rewiring degron network	0.25
p.N942K	SIDM01173	Rhabdomyosarcoma	GDSC	PDSSS	DEG_SPOP_SBC_1	945:949	Mutation rewiring degron network	0.25
p.N942K	SIDM00641	Burkitt's Lymphoma	GDSC	PDSSS	DEG_SPOP_SBC_1	945:949	Mutation rewiring degron network	0.25
p.P889S	SIDM00238	Ovarian Carcinoma	GDSC	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation rewiring degron network	0.25
p.P889S	OVK-18	ovary	COSMIC	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation rewiring degron network	0.25
p.P944R	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	945:949	Mutation rewiring degron network	0.3056
p.P944R	KYSE-140	oesophagus	COSMIC	PDSSS	DEG_SPOP_SBC_1	945:949	Mutation rewiring degron network	0.3056
p.R952Q	SIDM01105	Melanoma	GDSC	PDSSS	DEG_SPOP_SBC_1	945:949	Mutation rewiring degron network	0.25
p.R952Q	SK-MEL-3	skin	COSMIC	PDSSS	DEG_SPOP_SBC_1	945:949	Mutation rewiring degron network	0.25
p.R951Q	ACH-000423	Skin Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	945:949	Mutation rewiring degron network	0.2778
p.R951Q	SK-MEL-3	skin	COSMIC	PDSSS	DEG_SPOP_SBC_1	945:949	Mutation rewiring degron network	0.2778
p.P943R	ACH-000823	Esophageal Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	945:949	Mutation rewiring degron network	0.2778
p.P943R	KYSE-140	oesophagus	COSMIC	PDSSS	DEG_SPOP_SBC_1	945:949	Mutation rewiring degron network	0.2778
p.P888S	ACH-000947	Ovarian Cancer	CCLE	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation rewiring degron network	0.2222
p.P888S	OVK-18	ovary	COSMIC	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation rewiring degron network	0.2222
p.P882S	OVK-18	ovary	COSMIC	TEEATEATEVPDP	DEG_COP1_1	892:904	Mutation rewiring degron network	0.0556
p.P937R	KYSE-140	oesophagus	COSMIC	PDSSS	DEG_SPOP_SBC_1	945:949	Mutation rewiring degron network	0.1111
p.R945Q	SK-MEL-3	skin	COSMIC	PDSSS	DEG_SPOP_SBC_1	945:949	Mutation altering degron motif	0.7329

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAPK8IP3

UniProt ID: Q9UPT6

Entrez ID: 23162

Protein name: C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAPK8IP3 in