DegronMD

Uniprot ID: Q9UPT6

Source protein: C-Jun-amino-terminal kinase-interacting protein 3

Source gene: MAPK8IP3

Class: DEG_COP1_1

Location: 892:904

E3 ligase: COP1

DEGRON score: 0.9162

ASA_SCORE: 89.3231

COIL: 0.7589

CONS_SCORE: 0.3302

DSS_SCORE: 0.8403

HELIX: 0.1502

FCONS_SCORE: 1.1281

RIG_SCORE: 0.623

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E893K	TCGA-46-6025	LUSC	TCGA	TEEATEATEVPDP	DEG_COP1_1	0.7022
p.E893K	TCGA-55-A493	LUAD	TCGA	TEEATEATEVPDP	DEG_COP1_1	0.7022
p.P904H	TCGA-55-6979	LUAD	TCGA	TEEATEATEVPDP	DEG_COP1_1	0.7694
p.P906R	TCGA-DD-A1EE	LIHC	TCGA	TEEATEATEVPDP	DEG_COP1_1	0.2778
p.G884W	TCGA-EE-A29Q	SKCM	TCGA	TEEATEATEVPDP	DEG_COP1_1	0.1111
p.P888L	TCGA-QC-A7B5	SARC	TCGA	TEEATEATEVPDP	DEG_COP1_1	0.2222
p.R909W	DO223732	CESC	ICGC	TEEATEATEVPDP	DEG_COP1_1	0.1944
p.R909W	DO223703	COAD	ICGC	TEEATEATEVPDP	DEG_COP1_1	0.1944
p.R909Q	DO50346	ESAD	ICGC	TEEATEATEVPDP	DEG_COP1_1	0.1944
p.R909Q	DO52674	MALY	ICGC	TEEATEATEVPDP	DEG_COP1_1	0.1944
p.R909Q	MV-4-11	haematopoietic_and_lymphoid_tissue	COSMIC	TEEATEATEVPDP	DEG_COP1_1	0.1944
p.E902K	DO234226	ESAD	ICGC	TEEATEATEVPDP	DEG_COP1_1	0.7022
p.E902K	DO229462	SKCA	ICGC	TEEATEATEVPDP	DEG_COP1_1	0.7022
p.P900R	DO22857	LIHC	ICGC	TEEATEATEVPDP	DEG_COP1_1	0.7512
p.T905I	DO23290	LINC	ICGC	TEEATEATEVPDP	DEG_COP1_1	0.3056
p.P898H	DO24110	LUAD	ICGC	TEEATEATEVPDP	DEG_COP1_1	0.7694
p.E887K	DO26328	LUAD	ICGC	TEEATEATEVPDP	DEG_COP1_1	0.1944
p.E887K	DO26644	LUSC	ICGC	TEEATEATEVPDP	DEG_COP1_1	0.1944
p.P882L	DO220239	SARC	ICGC	TEEATEATEVPDP	DEG_COP1_1	0.0556
p.G911E	DO219468	SKCM	ICGC	TEEATEATEVPDP	DEG_COP1_1	0.1389
p.G911R	DO40889	UCEC	ICGC	TEEATEATEVPDP	DEG_COP1_1	0.1389
p.P889S	SIDM00238	Ovarian Carcinoma	GDSC	TEEATEATEVPDP	DEG_COP1_1	0.25
p.P889S	OVK-18	ovary	COSMIC	TEEATEATEVPDP	DEG_COP1_1	0.25
p.P888S	ACH-000947	Ovarian Cancer	CCLE	TEEATEATEVPDP	DEG_COP1_1	0.2222
p.P888S	OVK-18	ovary	COSMIC	TEEATEATEVPDP	DEG_COP1_1	0.2222
p.P882S	OVK-18	ovary	COSMIC	TEEATEATEVPDP	DEG_COP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPT6	C-Jun-amino-terminal kinase-interacting protein 3	DEG_COP1_1	892:904	TEEATEATEVPDP	COP1	0.9162	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TEEATEATEVPDP

Degron related mutations and impact score

Drug responses associated with MAPK8IP3 mutations

All proteins holding degron of TEEATEATEVPDP