DegronMD

Uniprot ID: Q9UPT6

Source protein: C-Jun-amino-terminal kinase-interacting protein 3

Source gene: MAPK8IP3

Class: DEG_COP1_1

Location: 275:283

E3 ligase: COP1

DEGRON score: 0.9828

ASA_SCORE: 86.8667

COIL: 0.9304

CONS_SCORE: 0.3923

DSS_SCORE: 0.6296

HELIX: 0.0467

FCONS_SCORE: 1.1561

RIG_SCORE: 0.6392

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S282L	TCGA-CV-6961	HNSC	TCGA	TPTSSVPSA	DEG_COP1_1	0.7667
p.S282L	TCGA-EK-A3GK	CESC	TCGA	TPTSSVPSA	DEG_COP1_1	0.7667
p.S282L	DO49964	CESC	ICGC	TPTSSVPSA	DEG_COP1_1	0.7667
p.S282L	DO14566	HNSC	ICGC	TPTSSVPSA	DEG_COP1_1	0.7667
p.S282L	ACH-000913	Endometrial/Uterine Cancer	CCLE	TPTSSVPSA	DEG_COP1_1	0.7667
p.S282L	ACH-002288	Embryonal Cancer	CCLE	TPTSSVPSA	DEG_COP1_1	0.7667
p.S282L	ESS-1	endometrium	COSMIC	TPTSSVPSA	DEG_COP1_1	0.7667
p.S282L	NEC8	testis	COSMIC	TPTSSVPSA	DEG_COP1_1	0.7667
p.A283T	TCGA-DU-6392	LGG	TCGA	TPTSSVPSA	DEG_COP1_1	0.7139
p.A283T	DO22237	LGG	ICGC	TPTSSVPSA	DEG_COP1_1	0.7139
p.S278F	TCGA-W3-A824	SKCM	TCGA	TPTSSVPSA	DEG_COP1_1	0.6871
p.S278F	DO51271	SKCM	ICGC	TPTSSVPSA	DEG_COP1_1	0.6871
p.T275M	DO233731	GACA	ICGC	TPTSSVPSA	DEG_COP1_1	0.7423
p.S283L	SIDM01043	Other Sarcomas	GDSC	TPTSSVPSA	DEG_COP1_1	0.7667
p.S283L	SIDM00243	Other Solid Cancers	GDSC	TPTSSVPSA	DEG_COP1_1	0.7667
p.S283L	ESS-1	endometrium	COSMIC	TPTSSVPSA	DEG_COP1_1	0.7667
p.S283L	NEC8	testis	COSMIC	TPTSSVPSA	DEG_COP1_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPT6	C-Jun-amino-terminal kinase-interacting protein 3	DEG_COP1_1	275:283	TPTSSVPSA	COP1	0.9828	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons