DegronMD

Uniprot ID: Q9UPT6

Source protein: C-Jun-amino-terminal kinase-interacting protein 3

Source gene: MAPK8IP3

Class: DEG_SIAH_1

Location: 280:288

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9885

ASA_SCORE: 79.0778

COIL: 0.9028

CONS_SCORE: 0.3636

DSS_SCORE: 0.6173

HELIX: 0.0648

FCONS_SCORE: 1.0555

RIG_SCORE: 0.6915

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y298C	TCGA-85-8582	LUSC	TCGA	VPSAAVTPL	DEG_SIAH_1	0.0556
p.Y298C	DO8858	COAD	ICGC	VPSAAVTPL	DEG_SIAH_1	0.0556
p.Y298C	DO45491	LUSC	ICGC	VPSAAVTPL	DEG_SIAH_1	0.0556
p.A284T	TCGA-CG-5721	STAD	TCGA	VPSAAVTPL	DEG_SIAH_1	0.6028
p.A284T	DO38192	STAD	ICGC	VPSAAVTPL	DEG_SIAH_1	0.6028
p.A284T	ACH-001610	Brain Cancer	CCLE	VPSAAVTPL	DEG_SIAH_1	0.6028
p.S282L	TCGA-CV-6961	HNSC	TCGA	VPSAAVTPL	DEG_SIAH_1	0.6556
p.S282L	TCGA-EK-A3GK	CESC	TCGA	VPSAAVTPL	DEG_SIAH_1	0.6556
p.S282L	DO49964	CESC	ICGC	VPSAAVTPL	DEG_SIAH_1	0.6556
p.S282L	DO14566	HNSC	ICGC	VPSAAVTPL	DEG_SIAH_1	0.6556
p.S282L	ACH-000913	Endometrial/Uterine Cancer	CCLE	VPSAAVTPL	DEG_SIAH_1	0.6556
p.S282L	ACH-002288	Embryonal Cancer	CCLE	VPSAAVTPL	DEG_SIAH_1	0.6556
p.S282L	ESS-1	endometrium	COSMIC	VPSAAVTPL	DEG_SIAH_1	0.6556
p.S282L	NEC8	testis	COSMIC	VPSAAVTPL	DEG_SIAH_1	0.6556
p.A283T	TCGA-DU-6392	LGG	TCGA	VPSAAVTPL	DEG_SIAH_1	0.7139
p.A283T	DO22237	LGG	ICGC	VPSAAVTPL	DEG_SIAH_1	0.7139
p.V285I	DO222790	COCA	ICGC	VPSAAVTPL	DEG_SIAH_1	0.7076
p.S283L	SIDM01043	Other Sarcomas	GDSC	VPSAAVTPL	DEG_SIAH_1	0.7667
p.S283L	SIDM00243	Other Solid Cancers	GDSC	VPSAAVTPL	DEG_SIAH_1	0.7667
p.S283L	ESS-1	endometrium	COSMIC	VPSAAVTPL	DEG_SIAH_1	0.7667
p.S283L	NEC8	testis	COSMIC	VPSAAVTPL	DEG_SIAH_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPT6	C-Jun-amino-terminal kinase-interacting protein 3	DEG_SIAH_1	280:288	VPSAAVTPL	SIAH1,SIAH2,SIAH3	0.9885	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons