DegronMD - O14981(BTAF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E277D	TCGA-D3-A2JC	SKCM	TCGA	PDSSS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.2222
p.G1815V	TCGA-D3-A3CE	SKCM	TCGA	ADTST	DEG_SPOP_SBC_1	1809:1813	Mutation rewiring degron network	0.2778
p.G1815V	DO37405	SKCM	ICGC	ADTST	DEG_SPOP_SBC_1	1809:1813	Mutation rewiring degron network	0.2778
p.S261Y	TCGA-D8-A27V	BRCA	TCGA	PDSSS	DEG_SPOP_SBC_1	269:273	Mutation blocking phosphorylation signal	0.5556
p.S261Y	DO6048	BRCA	ICGC	PDSSS	DEG_SPOP_SBC_1	269:273	Mutation blocking phosphorylation signal	0.5556
p.D1803N	TCGA-HQ-A5NE	BLCA	TCGA	ADTST	DEG_SPOP_SBC_1	1809:1813	Mutation rewiring degron network	0.1667
p.D1803N	DO51900	BLCA	ICGC	ADTST	DEG_SPOP_SBC_1	1809:1813	Mutation rewiring degron network	0.1667
p.S1812P	DO233865	GACA	ICGC	ADTST	DEG_SPOP_SBC_1	1809:1813	Mutation altering degron motif	0.7863
p.I265T	DO232849	NACA	ICGC	PDSSS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.2222
p.K1808T	DO36556	READ	ICGC	ADTST	DEG_SPOP_SBC_1	1809:1813	Mutation rewiring degron network	0.3056
p.V263A	DO229227	THCA	ICGC	PDSSS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1667
p.G1804D	SIDM00364	B-Lymphoblastic Leukemia	GDSC	ADTST	DEG_SPOP_SBC_1	1809:1813	Mutation rewiring degron network	0.1944
p.G1804D	ACH-002059	Leukemia	CCLE	ADTST	DEG_SPOP_SBC_1	1809:1813	Mutation rewiring degron network	0.1944
p.K1808E	SIDM00118	Colorectal Carcinoma	GDSC	ADTST	DEG_SPOP_SBC_1	1809:1813	Mutation rewiring degron network	0.3056
p.K1808E	ACH-001081	Colon/Colorectal Cancer	CCLE	ADTST	DEG_SPOP_SBC_1	1809:1813	Mutation rewiring degron network	0.3056
p.K1808E	HCC2998	large intestine	COSMIC	ADTST	DEG_SPOP_SBC_1	1809:1813	Mutation rewiring degron network	0.3056
p.P269S	ACH-000167	Myeloma	CCLE	PDSSS	DEG_SPOP_SBC_1	269:273	Mutation altering degron motif	0.6752
p.D260N	ACH-000973	Bladder Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.0833

Kaplan plot for BTAF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BTAF1

UniProt ID: O14981

Entrez ID: 9044

Protein name: TATA-binding protein-associated factor 172 (EC 3.6.4.-) (ATP-dependent helicase BTAF1) (B-TFIID transcription factor-associated 170 kDa subunit) (TAF(II)170) (TBP-associated factor 172) (TAF-172)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BTAF1 in