DegronMD

Uniprot ID: O14981

Source protein: TATA-binding protein-associated factor 172

Source gene: BTAF1

Class: DEG_SPOP_SBC_1

Location: 1809:1813

E3 ligase: SPOP

DEGRON score: 0.7564

ASA_SCORE: 89.38

COIL: 0.8148

CONS_SCORE: 0.2122

DSS_SCORE: 0.51

HELIX: 0.171

FCONS_SCORE: 0.7555

RIG_SCORE: 0.696

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1815V	TCGA-D3-A3CE	SKCM	TCGA	ADTST	DEG_SPOP_SBC_1	0.2778
p.G1815V	DO37405	SKCM	ICGC	ADTST	DEG_SPOP_SBC_1	0.2778
p.D1803N	TCGA-HQ-A5NE	BLCA	TCGA	ADTST	DEG_SPOP_SBC_1	0.1667
p.D1803N	DO51900	BLCA	ICGC	ADTST	DEG_SPOP_SBC_1	0.1667
p.S1812P	DO233865	GACA	ICGC	ADTST	DEG_SPOP_SBC_1	0.7863
p.K1808T	DO36556	READ	ICGC	ADTST	DEG_SPOP_SBC_1	0.3056
p.G1804D	SIDM00364	B-Lymphoblastic Leukemia	GDSC	ADTST	DEG_SPOP_SBC_1	0.1944
p.G1804D	ACH-002059	Leukemia	CCLE	ADTST	DEG_SPOP_SBC_1	0.1944
p.K1808E	SIDM00118	Colorectal Carcinoma	GDSC	ADTST	DEG_SPOP_SBC_1	0.3056
p.K1808E	ACH-001081	Colon/Colorectal Cancer	CCLE	ADTST	DEG_SPOP_SBC_1	0.3056
p.K1808E	HCC2998	large_intestine	COSMIC	ADTST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14981	TATA-binding protein-associated factor 172	DEG_SPOP_SBC_1	1809:1813	ADTST	SPOP	0.7564	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3306:3310	ADTST	SPOP	0.6241	More...
Q8N6T3	ADP-ribosylation factor GTPase-activating protein 1	DEG_SPOP_SBC_1	352:356	ADTST	SPOP	0.9997	More...
Q9Y2F5	Little elongation complex subunit 1	DEG_SPOP_SBC_1	1608:1612	ADTST	SPOP	0.9738	More...
Q6P9A1	Zinc finger protein 530	DEG_SPOP_SBC_1	83:87	ADTST	SPOP	0.8549	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons