DegronMD

Uniprot ID: Q9Y2F5

Source protein: Little elongation complex subunit 1

Source gene: ICE1

Class: DEG_SPOP_SBC_1

Location: 1608:1612

E3 ligase: SPOP

DEGRON score: 0.9738

ASA_SCORE: 91.86

COIL: 0.9388

CONS_SCORE: 0.401

DSS_SCORE: 0.6233

HELIX: 0.0338

FCONS_SCORE: 0.9106

RIG_SCORE: 0.66

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1600R	SIDM00643	Non-Cancerous	GDSC	ADTST	DEG_SPOP_SBC_1	0.1111
p.S1599R	SIDM01148	Plasma Cell Myeloma	GDSC	ADTST	DEG_SPOP_SBC_1	0.0833
p.S1599R	NCI-H929	haematopoietic_and_lymphoid_tissue	COSMIC	ADTST	DEG_SPOP_SBC_1	0.0833
p.P1618L	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	ADTST	DEG_SPOP_SBC_1	0.1667
p.P1618L	SIDM01494	Glioblastoma	GDSC	ADTST	DEG_SPOP_SBC_1	0.1667
p.P1618L	SIDM00163	Biliary Tract Carcinoma	GDSC	ADTST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14981	TATA-binding protein-associated factor 172	DEG_SPOP_SBC_1	1809:1813	ADTST	SPOP	0.7564	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3306:3310	ADTST	SPOP	0.6241	More...
Q8N6T3	ADP-ribosylation factor GTPase-activating protein 1	DEG_SPOP_SBC_1	352:356	ADTST	SPOP	0.9997	More...
Q9Y2F5	Little elongation complex subunit 1	DEG_SPOP_SBC_1	1608:1612	ADTST	SPOP	0.9738	More...
Q6P9A1	Zinc finger protein 530	DEG_SPOP_SBC_1	83:87	ADTST	SPOP	0.8549	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons