DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 3306:3310

E3 ligase: SPOP

DEGRON score: 0.6241

ASA_SCORE: 88.86

COIL: 0.903

CONS_SCORE: 0.5236

DSS_SCORE: 0.5759

HELIX: 0.0118

FCONS_SCORE: 1

RIG_SCORE: 0.6719

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3310S	TCGA-22-4613	LUSC	TCGA	ADTST	DEG_SPOP_SBC_1	0.6005
p.T3310S	DO26468	LUSC	ICGC	ADTST	DEG_SPOP_SBC_1	0.6005
p.T3313N	TCGA-D7-5579	STAD	TCGA	ADTST	DEG_SPOP_SBC_1	0.25
p.T3313N	DO38571	STAD	ICGC	ADTST	DEG_SPOP_SBC_1	0.25
p.S3299G	TCGA-E7-A4IJ	BLCA	TCGA	ADTST	DEG_SPOP_SBC_1	0.1389
p.S3299G	DO453	BLCA	ICGC	ADTST	DEG_SPOP_SBC_1	0.1389
p.D3307N	TCGA-HU-A4G8	STAD	TCGA	ADTST	DEG_SPOP_SBC_1	0.5821
p.D3307N	DO47819	STAD	ICGC	ADTST	DEG_SPOP_SBC_1	0.5821
p.S3299N	DO224754	COCA	ICGC	ADTST	DEG_SPOP_SBC_1	0.1389
p.S3299N	DO229013	COCA	ICGC	ADTST	DEG_SPOP_SBC_1	0.1389
p.S3299N	DO229016	COCA	ICGC	ADTST	DEG_SPOP_SBC_1	0.1389
p.S3299N	DO52365	LUSC	ICGC	ADTST	DEG_SPOP_SBC_1	0.1389
p.T3300S	DO224754	COCA	ICGC	ADTST	DEG_SPOP_SBC_1	0.1667
p.A3318G	DO231075	LUSC	ICGC	ADTST	DEG_SPOP_SBC_1	0.1111
p.S3309N	DO49185	PACA	ICGC	ADTST	DEG_SPOP_SBC_1	0.7069
p.S3309N	DO232761	PBCA	ICGC	ADTST	DEG_SPOP_SBC_1	0.7069
p.S3320L	DO219879	SKCA	ICGC	ADTST	DEG_SPOP_SBC_1	0.0556
p.V3312G	SIDM00120	Prostate Carcinoma	GDSC	ADTST	DEG_SPOP_SBC_1	0.2778
p.V3312G	ACH-000979	Prostate Cancer	CCLE	ADTST	DEG_SPOP_SBC_1	0.2778
p.V3312G	DU-145	prostate	COSMIC	ADTST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14981	TATA-binding protein-associated factor 172	DEG_SPOP_SBC_1	1809:1813	ADTST	SPOP	0.7564	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3306:3310	ADTST	SPOP	0.6241	More...
Q8N6T3	ADP-ribosylation factor GTPase-activating protein 1	DEG_SPOP_SBC_1	352:356	ADTST	SPOP	0.9997	More...
Q9Y2F5	Little elongation complex subunit 1	DEG_SPOP_SBC_1	1608:1612	ADTST	SPOP	0.9738	More...
Q6P9A1	Zinc finger protein 530	DEG_SPOP_SBC_1	83:87	ADTST	SPOP	0.8549	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons