DegronMD

Uniprot ID: Q6P9A1

Source protein: Zinc finger protein 530

Source gene: ZNF530

Class: DEG_SPOP_SBC_1

Location: 83:87

E3 ligase: SPOP

DEGRON score: 0.8549

ASA_SCORE: 77.44

COIL: 0.8236

CONS_SCORE: 0.4084

DSS_SCORE: 0.5371

HELIX: 0.0446

FCONS_SCORE: 1.125

RIG_SCORE: 0.635

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K89R	DO233106	GACA	ICGC	ADTST	DEG_SPOP_SBC_1	0.2778
p.L75P	DO228418	MALY	ICGC	ADTST	DEG_SPOP_SBC_1	0.1111
p.A83E	DO229240	THCA	ICGC	ADTST	DEG_SPOP_SBC_1	0.7701
p.E74A	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	ADTST	DEG_SPOP_SBC_1	0.0833
p.E74A	SIDM00650	Small Cell Lung Carcinoma	GDSC	ADTST	DEG_SPOP_SBC_1	0.0833
p.E74A	SIDM01681	Non-Cancerous	GDSC	ADTST	DEG_SPOP_SBC_1	0.0833
p.E94K	SIDM01084	Osteosarcoma	GDSC	ADTST	DEG_SPOP_SBC_1	0.1389
p.E94K	ACH-000410	Bone Cancer	CCLE	ADTST	DEG_SPOP_SBC_1	0.1389
p.E94K	Saos-2	bone	COSMIC	ADTST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14981	TATA-binding protein-associated factor 172	DEG_SPOP_SBC_1	1809:1813	ADTST	SPOP	0.7564	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3306:3310	ADTST	SPOP	0.6241	More...
Q8N6T3	ADP-ribosylation factor GTPase-activating protein 1	DEG_SPOP_SBC_1	352:356	ADTST	SPOP	0.9997	More...
Q9Y2F5	Little elongation complex subunit 1	DEG_SPOP_SBC_1	1608:1612	ADTST	SPOP	0.9738	More...
Q6P9A1	Zinc finger protein 530	DEG_SPOP_SBC_1	83:87	ADTST	SPOP	0.8549	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons