DegronMD - Q9Y2F5(ICE1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1655L	SIDM00969	Ovarian Carcinoma	GDSC	LIATPPRT	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.0833
p.S1655L	SIDM00654	Small Cell Lung Carcinoma	GDSC	LIATPPRT	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.0833
p.S1655L	SIDM00650	Small Cell Lung Carcinoma	GDSC	LIATPPRT	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.0833
p.S1655L	SIDM00493	Other Solid Cancers	GDSC	LIATPPRT	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.0833
p.S1655L	SIDM00844	Burkitt's Lymphoma	GDSC	LIATPPRT	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.0833
p.S1655L	SIDM01681	Non-Cancerous	GDSC	LIATPPRT	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.0833
p.S1655L	SIDM00808	Burkitt's Lymphoma	GDSC	LIATPPRT	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.0833
p.S1655L	SIDM01254	Burkitt's Lymphoma	GDSC	LIATPPRT	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.0833
p.S1655L	SIDM01525	Acute Myeloid Leukemia	GDSC	LIATPPRT	DEG_SCF_FBW7_1	1639:1646	Mutation rewiring degron network	0.0833
p.P1696T	SIDM00705	Non-Cancerous	GDSC	SASERVVPSP	DEG_COP1_1	1704:1713	Mutation rewiring degron network	0.1111
p.P1696T	SIDM01080	Oral Cavity Carcinoma	GDSC	SASERVVPSP	DEG_COP1_1	1704:1713	Mutation rewiring degron network	0.1111
p.P1696T	SIDM00696	Non-Cancerous	GDSC	SASERVVPSP	DEG_COP1_1	1704:1713	Mutation rewiring degron network	0.1111
p.P1696T	SIDM00772	Breast Carcinoma	GDSC	SASERVVPSP	DEG_COP1_1	1704:1713	Mutation rewiring degron network	0.1111
p.Q1600R	SIDM00643	Non-Cancerous	GDSC	ADTST	DEG_SPOP_SBC_1	1608:1612	Mutation rewiring degron network	0.1111
p.S1599R	SIDM01148	Plasma Cell Myeloma	GDSC	ADTST	DEG_SPOP_SBC_1	1608:1612	Mutation rewiring degron network	0.0833
p.S1599R	NCI-H929	haematopoietic and lymphoid tissue	COSMIC	ADTST	DEG_SPOP_SBC_1	1608:1612	Mutation rewiring degron network	0.0833
p.W1684C	SIDM00768	Non-Small Cell Lung Carcinoma	GDSC	VSPFRE	LIG_APCC_ABBA_1	1669:1674	Mutation rewiring degron network	0.0556
p.W1684C	NCI-H1869	lung	COSMIC	VSPFRE	LIG_APCC_ABBA_1	1669:1674	Mutation rewiring degron network	0.0556
p.P1618L	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	ADTST	DEG_SPOP_SBC_1	1608:1612	Mutation rewiring degron network	0.1667
p.P1618L	SIDM01494	Glioblastoma	GDSC	ADTST	DEG_SPOP_SBC_1	1608:1612	Mutation rewiring degron network	0.1667
p.P1618L	SIDM00163	Biliary Tract Carcinoma	GDSC	ADTST	DEG_SPOP_SBC_1	1608:1612	Mutation rewiring degron network	0.1667
p.I237T	GP5d	large intestine	COSMIC	AITSS	DEG_SPOP_SBC_1	236:240	Mutation altering degron motif	0.5966

Kaplan plot for ICE1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ICE1

UniProt ID: Q9Y2F5

Entrez ID: 23379

Protein name: Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ICE1 in