DegronMD

Uniprot ID: Q9Y2F5

Source protein: Little elongation complex subunit 1

Source gene: ICE1

Class: DEG_COP1_1

Location: 1704:1713

E3 ligase: COP1

DEGRON score: 0.9662

ASA_SCORE: 87.83

COIL: 0.8684

CONS_SCORE: 0.5457

DSS_SCORE: 0.5219

HELIX: 0.0486

FCONS_SCORE: 0.8352

RIG_SCORE: 0.6235

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1696T	SIDM00705	Non-Cancerous	GDSC	SASERVVPSP	DEG_COP1_1	0.1111
p.P1696T	SIDM01080	Oral Cavity Carcinoma	GDSC	SASERVVPSP	DEG_COP1_1	0.1111
p.P1696T	SIDM00696	Non-Cancerous	GDSC	SASERVVPSP	DEG_COP1_1	0.1111
p.P1696T	SIDM00772	Breast Carcinoma	GDSC	SASERVVPSP	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2F5	Little elongation complex subunit 1	DEG_COP1_1	1704:1713	SASERVVPSP	COP1	0.9662	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons