DegronMD

Uniprot ID: Q9Y2F5

Source protein: Little elongation complex subunit 1

Source gene: ICE1

Class: LIG_APCC_ABBA_1

Location: 1669:1674

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9911

ASA_SCORE: 104.55

COIL: 0.9112

CONS_SCORE: 0.6212

DSS_SCORE: 0.6559

HELIX: 0.0377

FCONS_SCORE: 1.1399

RIG_SCORE: 0.595

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W1684C	SIDM00768	Non-Small Cell Lung Carcinoma	GDSC	VSPFRE	LIG_APCC_ABBA_1	0.0556
p.W1684C	NCI-H1869	lung	COSMIC	VSPFRE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2F5	Little elongation complex subunit 1	LIG_APCC_ABBA_1	1669:1674	VSPFRE	APC,CDC20,FZR1	0.9911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons