DegronMD

Uniprot ID: Q9Y2F5

Source protein: Little elongation complex subunit 1

Source gene: ICE1

Class: DEG_SCF_FBW7_1

Location: 1639:1646

E3 ligase: FBXW7

DEGRON score: 0.9831

ASA_SCORE: 94.125

COIL: 0.9449

CONS_SCORE: 0.6404

DSS_SCORE: 0.6017

HELIX: 0.0131

FCONS_SCORE: 1.059

RIG_SCORE: 0.6826

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1655L	SIDM00969	Ovarian Carcinoma	GDSC	LIATPPRT	DEG_SCF_FBW7_1	0.0833
p.S1655L	SIDM00654	Small Cell Lung Carcinoma	GDSC	LIATPPRT	DEG_SCF_FBW7_1	0.0833
p.S1655L	SIDM00650	Small Cell Lung Carcinoma	GDSC	LIATPPRT	DEG_SCF_FBW7_1	0.0833
p.S1655L	SIDM00493	Other Solid Cancers	GDSC	LIATPPRT	DEG_SCF_FBW7_1	0.0833
p.S1655L	SIDM00844	Burkitt's Lymphoma	GDSC	LIATPPRT	DEG_SCF_FBW7_1	0.0833
p.S1655L	SIDM01681	Non-Cancerous	GDSC	LIATPPRT	DEG_SCF_FBW7_1	0.0833
p.S1655L	SIDM00808	Burkitt's Lymphoma	GDSC	LIATPPRT	DEG_SCF_FBW7_1	0.0833
p.S1655L	SIDM01254	Burkitt's Lymphoma	GDSC	LIATPPRT	DEG_SCF_FBW7_1	0.0833
p.S1655L	SIDM01525	Acute Myeloid Leukemia	GDSC	LIATPPRT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2F5	Little elongation complex subunit 1	DEG_SCF_FBW7_1	1639:1646	LIATPPRT	FBXW7	0.9831	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons