DegronMD

Uniprot ID: Q8N6T3

Source protein: ADP-ribosylation factor GTPase-activating protein 1

Source gene: ARFGAP1

Class: DEG_SPOP_SBC_1

Location: 352:356

E3 ligase: SPOP

DEGRON score: 0.9997

ASA_SCORE: 74.66

COIL: 0.843

CONS_SCORE: 0.2608

DSS_SCORE: 0.5398

HELIX: 0.1348

FCONS_SCORE: 1.0027

RIG_SCORE: 0.7294

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R355C	SIDM00980	Gastric Carcinoma	GDSC	ADTST	DEG_SPOP_SBC_1	0.8301
p.R355C	23132-87	stomach	COSMIC	ADTST	DEG_SPOP_SBC_1	0.8301
p.R355H	DO233941	GACA	ICGC	ADTST	DEG_SPOP_SBC_1	0.8244
p.R355H	DO43290	UCEC	ICGC	ADTST	DEG_SPOP_SBC_1	0.8244
p.P352L	SIDM00672	Hepatocellular Carcinoma	GDSC	ADTST	DEG_SPOP_SBC_1	0.7582
p.P352L	SIDM00694	Other Solid Cancers	GDSC	ADTST	DEG_SPOP_SBC_1	0.7582
p.D355N	SIDM00835	Colorectal Carcinoma	GDSC	ADTST	DEG_SPOP_SBC_1	0.6932
p.D355N	SW1116	large_intestine	COSMIC	ADTST	DEG_SPOP_SBC_1	0.6932
p.T348N	TCGA-AJ-A23O	UCEC	TCGA	ADTST	DEG_SPOP_SBC_1	0.6667
p.D361N	TCGA-OR-A5KB	ACC	TCGA	ADTST	DEG_SPOP_SBC_1	0.6389
p.S363F	TCGA-77-8154	LUSC	TCGA	ADTST	DEG_SPOP_SBC_1	0.5833
p.S363R	ACH-000817	Myeloma	CCLE	ADTST	DEG_SPOP_SBC_1	0.5833
p.S363R	ACH-002307	Lymphoma	CCLE	ADTST	DEG_SPOP_SBC_1	0.5833
p.S363R	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	ADTST	DEG_SPOP_SBC_1	0.5833
p.S363R	SU-DHL-16	haematopoietic_and_lymphoid_tissue	COSMIC	ADTST	DEG_SPOP_SBC_1	0.5833
p.S345G	ACH-001377	Pancreatic Cancer	CCLE	ADTST	DEG_SPOP_SBC_1	0.5833
p.P343L	DO233156	GACA	ICGC	ADTST	DEG_SPOP_SBC_1	0.5278
p.P343L	DO222837	MELA	ICGC	ADTST	DEG_SPOP_SBC_1	0.5278
p.L358P	SIDM00186	Kidney Carcinoma	GDSC	ADTST	DEG_SPOP_SBC_1	0.2778
p.C359Y	TCGA-DD-AADF	LIHC	TCGA	ADTST	DEG_SPOP_SBC_1	0.25
p.R349H	TCGA-K4-A6MB	BLCA	TCGA	ADTST	DEG_SPOP_SBC_1	0.25
p.A349T	DO10324	COAD	ICGC	ADTST	DEG_SPOP_SBC_1	0.25
p.A349T	SIDM01113	Other Sarcomas	GDSC	ADTST	DEG_SPOP_SBC_1	0.25
p.A349T	SK-UT-1	soft_tissue	COSMIC	ADTST	DEG_SPOP_SBC_1	0.25
p.R359T	ACH-001375	Pancreatic Cancer	CCLE	ADTST	DEG_SPOP_SBC_1	0.25

Showing 1 to 25 of 30 entries

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Drug responses associated with ARFGAP1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00814	ACC\|adrenal_gland	p.A81S (No)	GDSC	QS11	10.553
SIDM00145	ALL\|lymphoblastic_leukemia	p.A27T (No)	GDSC	QS11	11.2827
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R182H (No)	GDSC	QS11	8.4348
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R58H (No)	GDSC	QS11	8.4348
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.G336D (No)	GDSC	QS11	8.4348
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.G394C (No)	GDSC	QS11	8.4348
SIDM00999	BLCA\|bladder	p.A265V (No)	GDSC	QS11	1.3307
SIDM00807	BLCA\|bladder	p.R375Q (No)	GDSC	QS11	3.5462
SIDM00879	BRCA\|breast	p.R187fs*159 (No)	GDSC	QS11	63.4313
SIDM00146	BRCA\|breast	p.P323H (No)	GDSC	QS11	24.82
SIDM01001	BRCA\|breast	p.V184M (No)	GDSC	QS11	1.6692
SIDM01090	COREAD\|large_intestine	p.A27T (No)	GDSC	QS11	4.199
SIDM00282	COREAD\|large_intestine	p.Y103H (No)	GDSC	QS11	258.3874
SIDM00150	COREAD\|large_intestine	p.G242D (No)	GDSC	QS11	14.4345
SIDM00783	COREAD\|large_intestine	p.A286V (No)	GDSC	QS11	21.9357
SIDM00487	COREAD\|large_intestine	p.G308S (No)	GDSC	QS11	26.6896
SIDM00404	DLBC\|B_cell_lymphoma	p.S371R (No)	GDSC	QS11	4.362
SIDM00416	DLBC\|B_cell_lymphoma	p.N331S (No)	GDSC	QS11	6.8967
SIDM00249	ESCA\|oesophagus	p.S280N (No)	GDSC	QS11	24.8737
SIDM01030	ESCA\|oesophagus	p.A39_Q43delAQAPQ (No)	GDSC	QS11	9.5801
SIDM00382	GBM\|glioma	p.A265V (No)	GDSC	QS11	25.8731
SIDM00077	HNSC\|head_and_neck	p.V145I (No)	GDSC	QS11	166.3367
SIDM00350	HNSC\|head_and_neck	p.W36_P42delinsCT (No)	GDSC	QS11	274.1121
SIDM00849	KIRC\|kidney	p.R34W (No)	GDSC	QS11	107.4058
SIDM00318	KIRC\|kidney	p.P156S (No)	GDSC	QS11	11.0489

Showing 1 to 25 of 61 entries

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All proteins holding degron of ADTST

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N6T3	ADP-ribosylation factor GTPase-activating protein 1	DEG_SPOP_SBC_1	352:356	ADTST	SPOP	0.9997	More...
Q9Y2F5	Little elongation complex subunit 1	DEG_SPOP_SBC_1	1608:1612	ADTST	SPOP	0.9738	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3306:3310	ADTST	SPOP	0.6241	More...
O14981	TATA-binding protein-associated factor 172	DEG_SPOP_SBC_1	1809:1813	ADTST	SPOP	0.7564	More...
Q6P9A1	Zinc finger protein 530	DEG_SPOP_SBC_1	83:87	ADTST	SPOP	0.8549	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ADTST

Degron related mutations and impact score

Drug responses associated with ARFGAP1 mutations

All proteins holding degron of ADTST