DegronMD

Uniprot ID: Q8N6T3

Source protein: ADP-ribosylation factor GTPase-activating protein 1

Source gene: ARFGAP1

Class: DEG_SPOP_SBC_1

Location: 352:356

E3 ligase: SPOP

DEGRON score: 0.9997

ASA_SCORE: 74.66

COIL: 0.843

CONS_SCORE: 0.2608

DSS_SCORE: 0.5398

HELIX: 0.1348

FCONS_SCORE: 1.0027

RIG_SCORE: 0.7294

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S363F	TCGA-77-8154	LUSC	TCGA	ADTST	DEG_SPOP_SBC_1	0.5833
p.T348N	TCGA-AJ-A23O	UCEC	TCGA	ADTST	DEG_SPOP_SBC_1	0.6667
p.C359Y	TCGA-DD-AADF	LIHC	TCGA	ADTST	DEG_SPOP_SBC_1	0.25
p.E365K	TCGA-DJ-A3VL	THCA	TCGA	ADTST	DEG_SPOP_SBC_1	0.0833
p.E365K	TCGA-VQ-A8PT	STAD	TCGA	ADTST	DEG_SPOP_SBC_1	0.0833
p.R349H	TCGA-K4-A6MB	BLCA	TCGA	ADTST	DEG_SPOP_SBC_1	0.25
p.D361N	TCGA-OR-A5KB	ACC	TCGA	ADTST	DEG_SPOP_SBC_1	0.6389
p.A349T	DO10324	COAD	ICGC	ADTST	DEG_SPOP_SBC_1	0.25
p.A349T	SIDM01113	Other Sarcomas	GDSC	ADTST	DEG_SPOP_SBC_1	0.25
p.A349T	SK-UT-1	soft_tissue	COSMIC	ADTST	DEG_SPOP_SBC_1	0.25
p.P343L	DO233156	GACA	ICGC	ADTST	DEG_SPOP_SBC_1	0.5278
p.P343L	DO222837	MELA	ICGC	ADTST	DEG_SPOP_SBC_1	0.5278
p.R355H	DO233941	GACA	ICGC	ADTST	DEG_SPOP_SBC_1	0.8244
p.R355H	DO43290	UCEC	ICGC	ADTST	DEG_SPOP_SBC_1	0.8244
p.P352L	SIDM00672	Hepatocellular Carcinoma	GDSC	ADTST	DEG_SPOP_SBC_1	0.7582
p.P352L	SIDM00694	Other Solid Cancers	GDSC	ADTST	DEG_SPOP_SBC_1	0.7582
p.L358P	SIDM00186	Kidney Carcinoma	GDSC	ADTST	DEG_SPOP_SBC_1	0.2778
p.D355N	SIDM00835	Colorectal Carcinoma	GDSC	ADTST	DEG_SPOP_SBC_1	0.6932
p.D355N	SW1116	large_intestine	COSMIC	ADTST	DEG_SPOP_SBC_1	0.6932
p.R355C	SIDM00980	Gastric Carcinoma	GDSC	ADTST	DEG_SPOP_SBC_1	0.8301
p.R355C	23132-87	stomach	COSMIC	ADTST	DEG_SPOP_SBC_1	0.8301
p.D347N	ACH-000489	Colon/Colorectal Cancer	CCLE	ADTST	DEG_SPOP_SBC_1	0.1944
p.D347N	SW1116	large_intestine	COSMIC	ADTST	DEG_SPOP_SBC_1	0.1944
p.S363R	ACH-000817	Myeloma	CCLE	ADTST	DEG_SPOP_SBC_1	0.5833
p.S363R	ACH-002307	Lymphoma	CCLE	ADTST	DEG_SPOP_SBC_1	0.5833
p.S363R	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	ADTST	DEG_SPOP_SBC_1	0.5833
p.S363R	SU-DHL-16	haematopoietic_and_lymphoid_tissue	COSMIC	ADTST	DEG_SPOP_SBC_1	0.5833
p.R359T	ACH-001375	Pancreatic Cancer	CCLE	ADTST	DEG_SPOP_SBC_1	0.25
p.S345G	ACH-001377	Pancreatic Cancer	CCLE	ADTST	DEG_SPOP_SBC_1	0.5833
p.S359F	SNU-1040	large_intestine	COSMIC	ADTST	DEG_SPOP_SBC_1	0.25

Drug responses associated with ARFGAP1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00358	STAD\|stomach	p.I41V (No)	GDSC	QS11	11.6372
SIDM00087	MM\|myeloma	p.S371R (No)	GDSC	QS11	6.6713
SIDM00145	ALL\|lymphoblastic_leukemia	p.A27T (No)	GDSC	QS11	11.2827
SIDM01139	PAAD\|pancreas	p.L86P (No)	GDSC	QS11	191.4326
SIDM00849	KIRC\|kidney	p.R34W (No)	GDSC	QS11	107.4058
SIDM00382	GBM\|glioma	p.A265V (No)	GDSC	QS11	25.8731
SIDM01034	UNCLASSIFIED\|B_cell_leukemia	p.C17F (No)	GDSC	QS11	6.7282
SIDM00879	BRCA\|breast	p.R187fs*159 (No)	GDSC	QS11	63.4313
SIDM00146	BRCA\|breast	p.P323H (No)	GDSC	QS11	24.82
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.R134C (No)	GDSC	QS11	97.131
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.S370L (No)	GDSC	QS11	97.131
SIDM00980	STAD\|stomach	p.R355C (Yes)	GDSC	QS11	4.2336
SIDM00742	LUAD\|lung_NSCLC_adenocarcinoma	p.G388C (No)	GDSC	QS11	14.2098
SIDM00318	KIRC\|kidney	p.P156S (No)	GDSC	QS11	11.0489
SIDM00814	ACC\|adrenal_gland	p.A81S (No)	GDSC	QS11	10.553
SIDM01090	COREAD\|large_intestine	p.A27T (No)	GDSC	QS11	4.199
SIDM00252	UNCLASSIFIED\|biliary_tract	p.L99S (No)	GDSC	QS11	142.6684
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.S280N (No)	GDSC	QS11	1.661
SIDM00251	STAD\|stomach	p.K324fs*8 (No)	GDSC	QS11	25.3174
SIDM01045	UCEC\|endometrium	p.A27V (No)	GDSC	QS11	219.2192
SIDM00404	DLBC\|B_cell_lymphoma	p.S371R (No)	GDSC	QS11	4.362
SIDM00794	UNCLASSIFIED\|skin_other	p.T196S (No)	GDSC	QS11	32.6769
SIDM00249	ESCA\|oesophagus	p.S280N (No)	GDSC	QS11	24.8737
SIDM00077	HNSC\|head_and_neck	p.V145I (No)	GDSC	QS11	166.3367
SIDM00999	BLCA\|bladder	p.A265V (No)	GDSC	QS11	1.3307
SIDM00807	BLCA\|bladder	p.R375Q (No)	GDSC	QS11	3.5462
SIDM00282	COREAD\|large_intestine	p.Y103H (No)	GDSC	QS11	258.3874
SIDM00150	COREAD\|large_intestine	p.G242D (No)	GDSC	QS11	14.4345
SIDM01137	PAAD\|pancreas	p.K288E (No)	GDSC	QS11	39.0788
SIDM00783	COREAD\|large_intestine	p.A286V (No)	GDSC	QS11	21.9357
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.P78L (No)	GDSC	QS11	16.45
SIDM00739	LUAD\|lung_NSCLC_adenocarcinoma	p.R84Q (No)	GDSC	QS11	32.0281
SIDM01030	ESCA\|oesophagus	p.A39_Q43delAQAPQ (No)	GDSC	QS11	9.5801
SIDM00116	LUAD\|lung_NSCLC_adenocarcinoma	p.D333N (No)	GDSC	QS11	34.5963
SIDM00324	NB\|neuroblastoma	p.N133K (No)	GDSC	QS11	26.8644
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P42S (No)	GDSC	QS11	3.8198
SIDM00350	HNSC\|head_and_neck	p.W36_P42delinsCT (No)	GDSC	QS11	274.1121
SIDM00487	COREAD\|large_intestine	p.G308S (No)	GDSC	QS11	26.6896
SIDM00368	SCLC\|lung_small_cell_carcinoma	p.V184M (No)	GDSC	QS11	11.07
SIDM00850	STAD\|stomach	p.R187fs*159 (No)	GDSC	QS11	5.265
SIDM00092	OV\|ovary	p.L207M (No)	GDSC	QS11	12.4541
SIDM00748	UNCLASSIFIED\|lung_NSCLC_large_cell	p.V15M (No)	GDSC	QS11	71.8892
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R182H (No)	GDSC	QS11	8.4348
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R58H (No)	GDSC	QS11	8.4348
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.G336D (No)	GDSC	QS11	8.4348
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.G394C (No)	GDSC	QS11	8.4348
SIDM00040	STAD\|stomach	p.R297C (No)	GDSC	QS11	19.8059
SIDM00980	STAD\|stomach	p.S303fs*30 (No)	GDSC	QS11	4.2336
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.A349T (Yes)	GDSC	QS11	27.8535
SIDM00561	UNCLASSIFIED\|hairy_cell_leukaemia	p.C279Y (No)	GDSC	QS11	28.7663
SIDM01111	UNCLASSIFIED\|ewings_sarcoma	p.T312M (No)	GDSC	QS11	4.099
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.E267D (No)	GDSC	QS11	71.8082
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.Q317H (No)	GDSC	QS11	151.8901
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.A318S (No)	GDSC	QS11	151.8901
SIDM00120	PRAD\|prostate	p.K324fs*8 (No)	GDSC	QS11	5.8694
SIDM00291	SKCM\|melanoma	p.S280N (No)	GDSC	QS11	6.3648
SIDM00623	UNCLASSIFIED\|hairy_cell_leukaemia	p.R282H (No)	GDSC	QS11	126.4127
SIDM00055	LUAD\|lung_NSCLC_adenocarcinoma	p.R187fs*159 (No)	GDSC	QS11	7.3345
SIDM01001	BRCA\|breast	p.V184M (No)	GDSC	QS11	1.6692
SIDM00333	UCEC\|endometrium	p.P222fs*124 (No)	GDSC	QS11	6.1537
SIDM00416	DLBC\|B_cell_lymphoma	p.N331S (No)	GDSC	QS11	6.8967

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14981	TATA-binding protein-associated factor 172	DEG_SPOP_SBC_1	1809:1813	ADTST	SPOP	0.7564	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3306:3310	ADTST	SPOP	0.6241	More...
Q8N6T3	ADP-ribosylation factor GTPase-activating protein 1	DEG_SPOP_SBC_1	352:356	ADTST	SPOP	0.9997	More...
Q9Y2F5	Little elongation complex subunit 1	DEG_SPOP_SBC_1	1608:1612	ADTST	SPOP	0.9738	More...
Q6P9A1	Zinc finger protein 530	DEG_SPOP_SBC_1	83:87	ADTST	SPOP	0.8549	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ADTST

Degron related mutations and impact score

Drug responses associated with ARFGAP1 mutations

All proteins holding degron of ADTST