DegronMD - Q8N6T3(ARFGAP1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S363F	TCGA-77-8154	LUSC	TCGA	ADTST	DEG_SPOP_SBC_1	352:356	Mutation blocking phosphorylation signal	0.5833
p.T348N	TCGA-AJ-A23O	UCEC	TCGA	ADTST	DEG_SPOP_SBC_1	352:356	Mutation blocking phosphorylation signal	0.6667
p.C359Y	TCGA-DD-AADF	LIHC	TCGA	ADTST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.25
p.E365K	TCGA-DJ-A3VL	THCA	TCGA	ADTST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.0833
p.E365K	TCGA-VQ-A8PT	STAD	TCGA	ADTST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.0833
p.R349H	TCGA-K4-A6MB	BLCA	TCGA	ADTST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.25
p.D361N	TCGA-OR-A5KB	ACC	TCGA	ADTST	DEG_SPOP_SBC_1	352:356	Mutation blocking phosphorylation signal	0.6389
p.A349T	DO10324	COAD	ICGC	ADTST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.25
p.A349T	SIDM01113	Other Sarcomas	GDSC	ADTST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.25
p.A349T	SK-UT-1	soft tissue	COSMIC	ADTST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.25
p.P343L	DO233156	GACA	ICGC	ADTST	DEG_SPOP_SBC_1	352:356	Mutation blocking phosphorylation signal	0.5278
p.P343L	DO222837	MELA	ICGC	ADTST	DEG_SPOP_SBC_1	352:356	Mutation blocking phosphorylation signal	0.5278
p.R355H	DO233941	GACA	ICGC	ADTST	DEG_SPOP_SBC_1	352:356	Mutation altering degron motif	0.8244
p.R355H	DO43290	UCEC	ICGC	ADTST	DEG_SPOP_SBC_1	352:356	Mutation altering degron motif	0.8244
p.P352L	SIDM00672	Hepatocellular Carcinoma	GDSC	ADTST	DEG_SPOP_SBC_1	352:356	Mutation altering degron motif	0.7582
p.P352L	SIDM00694	Other Solid Cancers	GDSC	ADTST	DEG_SPOP_SBC_1	352:356	Mutation altering degron motif	0.7582
p.L358P	SIDM00186	Kidney Carcinoma	GDSC	ADTST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.2778
p.D355N	SIDM00835	Colorectal Carcinoma	GDSC	ADTST	DEG_SPOP_SBC_1	352:356	Mutation altering degron motif	0.6932
p.D355N	SW1116	large intestine	COSMIC	ADTST	DEG_SPOP_SBC_1	352:356	Mutation altering degron motif	0.6932
p.R355C	SIDM00980	Gastric Carcinoma	GDSC	ADTST	DEG_SPOP_SBC_1	352:356	Mutation altering degron motif	0.8301
p.R355C	23132-87	stomach	COSMIC	ADTST	DEG_SPOP_SBC_1	352:356	Mutation altering degron motif	0.8301
p.D347N	ACH-000489	Colon/Colorectal Cancer	CCLE	ADTST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.1944
p.D347N	SW1116	large intestine	COSMIC	ADTST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.1944
p.S363R	ACH-000817	Myeloma	CCLE	ADTST	DEG_SPOP_SBC_1	352:356	Mutation blocking phosphorylation signal	0.5833
p.S363R	ACH-002307	Lymphoma	CCLE	ADTST	DEG_SPOP_SBC_1	352:356	Mutation blocking phosphorylation signal	0.5833
p.S363R	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	ADTST	DEG_SPOP_SBC_1	352:356	Mutation blocking phosphorylation signal	0.5833
p.S363R	SU-DHL-16	haematopoietic and lymphoid tissue	COSMIC	ADTST	DEG_SPOP_SBC_1	352:356	Mutation blocking phosphorylation signal	0.5833
p.R359T	ACH-001375	Pancreatic Cancer	CCLE	ADTST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.25
p.S345G	ACH-001377	Pancreatic Cancer	CCLE	ADTST	DEG_SPOP_SBC_1	352:356	Mutation blocking phosphorylation signal	0.5833
p.S359F	SNU-1040	large intestine	COSMIC	ADTST	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.25

Kaplan plot for ARFGAP1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARFGAP1

UniProt ID: Q8N6T3

Entrez ID: 55738

Protein name: ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ARFGAP1 in