DegronMD - Q9NWZ3(IRAK4)

IRAK4

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S144I	TCGA-06-2569	GBM	TCGA	PDSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.2222
p.P148A	TCGA-61-1900	OV	TCGA	PDSSS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.6392
p.Q139P	TCGA-A5-A0G2	UCEC	TCGA	PDSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0833
p.Q139H	TCGA-XF-A9ST	BLCA	TCGA	PDSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0833
p.D148H	DO502	BLCA	ICGC	PDSSS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.7688
p.G144A	DO233262	GACA	ICGC	PDSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.2222
p.L146F	DO229009	LICA	ICGC	PDSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.2778
p.G144S	DO232462	PBCA	ICGC	PDSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.2222
p.Y138H	DO38887	STAD	ICGC	PDSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0556
p.P153A	SIDM00365	Small Cell Lung Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.3056
p.P153A	ACH-002196	Lung Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.3056
p.P153A	SBC-1	lung	COSMIC	PDSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc