DegronMD

Uniprot ID: Q9NWZ3

Source protein: Interleukin-1 receptor-associated kinase 4

Source gene: IRAK4

Class: DEG_SPOP_SBC_1

Location: 148:152

E3 ligase: SPOP

DEGRON score: 0.9855

ASA_SCORE: 88.1

COIL: 0.9558

CONS_SCORE: 0.3958

DSS_SCORE: 0.6389

HELIX: 0.0292

FCONS_SCORE: 1.112

RIG_SCORE: 0.5785

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S144I	TCGA-06-2569	GBM	TCGA	PDSSS	DEG_SPOP_SBC_1	0.2222
p.P148A	TCGA-61-1900	OV	TCGA	PDSSS	DEG_SPOP_SBC_1	0.6392
p.Q139P	TCGA-A5-A0G2	UCEC	TCGA	PDSSS	DEG_SPOP_SBC_1	0.0833
p.Q139H	TCGA-XF-A9ST	BLCA	TCGA	PDSSS	DEG_SPOP_SBC_1	0.0833
p.D148H	DO502	BLCA	ICGC	PDSSS	DEG_SPOP_SBC_1	0.7688
p.G144A	DO233262	GACA	ICGC	PDSSS	DEG_SPOP_SBC_1	0.2222
p.L146F	DO229009	LICA	ICGC	PDSSS	DEG_SPOP_SBC_1	0.2778
p.G144S	DO232462	PBCA	ICGC	PDSSS	DEG_SPOP_SBC_1	0.2222
p.Y138H	DO38887	STAD	ICGC	PDSSS	DEG_SPOP_SBC_1	0.0556
p.P153A	SIDM00365	Small Cell Lung Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	0.3056
p.P153A	ACH-002196	Lung Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	0.3056
p.P153A	SBC-1	lung	COSMIC	PDSSS	DEG_SPOP_SBC_1	0.3056

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00358	STAD\|stomach	p.R183Q (No)	GDSC	IRAK4_4710	279.02
SIDM00614	LIHC\|liver	p.R183Q (No)	GDSC	IRAK4_4710	188.06
SIDM00023	ESCA\|oesophagus	p.W74* (No)	GDSC	IRAK4_4710	137.88
SIDM00584	UNCLASSIFIED\|osteosarcoma	p.I5V (No)	GDSC	IRAK4_4710	48.564
SIDM00527	COREAD\|large_intestine	p.M218I (No)	GDSC	IRAK4_4710	62.409
SIDM01007	ALL\|lymphoblastic_leukemia	p.I381V (No)	GDSC	IRAK4_4710	47.684
SIDM00537	COREAD\|large_intestine	p.K41fs*13 (No)	GDSC	IRAK4_4710	266.44
SIDM00630	BRCA\|breast	p.H390R (No)	GDSC	IRAK4_4710	191.71
SIDM00217	COREAD\|large_intestine	p.K416R (No)	GDSC	IRAK4_4710	213.4
SIDM00660	COREAD\|large_intestine	p.Q139* (Yes)	GDSC	IRAK4_4710	75.023
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.A38V (No)	GDSC	IRAK4_4710	175.27
SIDM00448	DLBC\|B_cell_lymphoma	p.H306N (No)	GDSC	IRAK4_4710	235.89
SIDM01005	LAML\|acute_myeloid_leukaemia	p.R183Q (No)	GDSC	IRAK4_4710	22.104
SIDM00119	LUAD\|lung_NSCLC_adenocarcinoma	p.S425fs*33 (No)	GDSC	IRAK4_4710	150.41
SIDM00238	OV\|ovary	p.R183Q (No)	GDSC	IRAK4_4710	333.18

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00507	Probable ubiquitin carboxyl-terminal hydrolase FAF-Y	DEG_SPOP_SBC_1	977:981	PDSSS	SPOP	0.9861	More...
O14981	TATA-binding protein-associated factor 172	DEG_SPOP_SBC_1	269:273	PDSSS	SPOP	0.935	More...
P02751	Fibronectin	DEG_SPOP_SBC_1	1863:1867	PDSSS	SPOP	0.902	More...
P23760	Paired box protein Pax-3	DEG_SPOP_SBC_1	348:352	PDSSS	SPOP	0.9277	More...
P28702	Retinoic acid receptor RXR-beta	DEG_SPOP_SBC_1	83:87	PDSSS	SPOP	0.9539	More...
P48553	Trafficking protein particle complex subunit 10	DEG_SPOP_SBC_1	1199:1203	PDSSS	SPOP	0.9812	More...
P56645	Period circadian protein homolog 3	DEG_SPOP_SBC_1	748:752	PDSSS	SPOP	0.8579	More...
Q12947	Forkhead box protein F2	DEG_SPOP_SBC_1	310:314	PDSSS	SPOP	0.9763	More...
Q12948	Forkhead box protein C1	DEG_SPOP_SBC_1	260:264	PDSSS	SPOP	0.9877	More...
Q14517	Protocadherin Fat 1	DEG_SPOP_SBC_1	1166:1170	PDSSS	SPOP	0.9878	More...
Q15642	Cdc42-interacting protein 4	DEG_SPOP_SBC_1	498:502	PDSSS	SPOP	0.9962	More...
Q6VAB6	Kinase suppressor of Ras 2	DEG_SPOP_SBC_1	515:519	PDSSS	SPOP	0.9977	More...
Q7LBE3	Solute carrier family 26 member 9	DEG_SPOP_SBC_1	629:633	PDSSS	SPOP	0.9618	More...
Q7Z333	Probable helicase senataxin	DEG_SPOP_SBC_1	1485:1489	PDSSS	SPOP	0.8761	More...
Q86VZ4	Low-density lipoprotein receptor-related protein 11	DEG_SPOP_SBC_1	417:421	PDSSS	SPOP	0.9592	More...
Q8N441	Fibroblast growth factor receptor-like 1	DEG_SPOP_SBC_1	129:133	PDSSS	SPOP	0.8851	More...
Q8TE77	Protein phosphatase Slingshot homolog 3	DEG_SPOP_SBC_1	152:156	PDSSS	SPOP	0.7282	More...
Q92613	Protein Jade-3	DEG_SPOP_SBC_1	567:571	PDSSS	SPOP	0.9916	More...
Q93008	Probable ubiquitin carboxyl-terminal hydrolase FAF-X	DEG_SPOP_SBC_1	976:980	PDSSS	SPOP	0.9934	More...
Q9BRK4	Leucine zipper putative tumor suppressor 2	DEG_SPOP_SBC_1	302:306	PDSSS	SPOP	0.9992	More...
Q9BWT3	Poly	DEG_SPOP_SBC_1	712:716	PDSSS	SPOP	0.9943	More...
Q9H4Z2	Zinc finger protein 335	DEG_SPOP_SBC_1	86:90	PDSSS	SPOP	0.9916	More...
Q9NWZ3	Interleukin-1 receptor-associated kinase 4	DEG_SPOP_SBC_1	148:152	PDSSS	SPOP	0.9855	More...
Q9NXG0	Centlein	DEG_SPOP_SBC_1	1396:1400	PDSSS	SPOP	0.9251	More...
Q9UPT6	C-Jun-amino-terminal kinase-interacting protein 3	DEG_SPOP_SBC_1	945:949	PDSSS	SPOP	0.9951	More...
P31267	Homeobox protein Hox-A6	DEG_SPOP_SBC_1	113:117	PDSSS	SPOP	0.545	More...
Q2T9L4	Inhibitory synaptic factor 1	DEG_SPOP_SBC_1	157:161	PDSSS	SPOP	0.9993	More...
Q5H9T9	Fibrous sheath CABYR-binding protein	DEG_SPOP_SBC_1	170:174	PDSSS	SPOP	0.9796	More...
Q8TA94	Zinc finger protein 563	DEG_SPOP_SBC_1	263:267	PDSSS	SPOP	0.9213	More...
P13985	Putative HTLV-1-related endogenous sequence	DEG_SPOP_SBC_1	139:143	PDSSS	SPOP	0.8586	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PDSSS

Degron related mutations and impact score

Drug responses associated with IRAK4 mutations

All proteins holding degron of PDSSS