DegronMD - Q7Z333(SETX)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I1233M	TCGA-05-4389	LUAD	TCGA	VSKTPKKT	DEG_SCF_FBW7_1	1238:1245	Mutation rewiring degron network	0.1944
p.I1233M	DO24307	LUAD	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	1238:1245	Mutation rewiring degron network	0.1944
p.Q1253H	TCGA-06-5416	GBM	TCGA	VSKTPKKT	DEG_SCF_FBW7_1	1238:1245	Mutation rewiring degron network	0.1111
p.Q1253H	DO10880	GBM	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	1238:1245	Mutation rewiring degron network	0.1111
p.A2500S	TCGA-17-Z062	LUAD	TCGA	DSGFAKT	DEG_SCF_TRCP1_1	2496:2502	Mutation altering degron motif	0.6477
p.E1476K	TCGA-22-5473	LUSC	TCGA	PDSSS	DEG_SPOP_SBC_1	1485:1489	Mutation rewiring degron network	0.0833
p.E1476K	DO26467	LUSC	ICGC	PDSSS	DEG_SPOP_SBC_1	1485:1489	Mutation rewiring degron network	0.0833
p.P898H	TCGA-49-6761	LUAD	TCGA	LIPFTE	LIG_APCC_ABBA_1	896:901	Mutation altering degron motif	0.7694
p.P898H	DO24566	LUAD	ICGC	LIPFTE	LIG_APCC_ABBA_1	896:901	Mutation altering degron motif	0.7694
p.L2495P	TCGA-60-2723	LUSC	TCGA	DSGFAKT	DEG_SCF_TRCP1_1	2496:2502	Mutation rewiring degron network	0.3056
p.E1231K	TCGA-93-8067	LUAD	TCGA	VSKTPKKT	DEG_SCF_FBW7_1	1238:1245	Mutation rewiring degron network	0.1389
p.E1231K	DO25113	LUAD	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	1238:1245	Mutation rewiring degron network	0.1389
p.D1553Y	TCGA-A5-A0G2	UCEC	TCGA	SRPQLESLS	DEG_APCC_DBOX_1	1537:1545	Mutation rewiring degron network	0.1111
p.D1553Y	DO41235	UCEC	ICGC	SRPQLESLS	DEG_APCC_DBOX_1	1537:1545	Mutation rewiring degron network	0.1111
p.K1250N	TCGA-AG-A002	READ	TCGA	VSKTPKKT	DEG_SCF_FBW7_1	1238:1245	Mutation substituting flanking lysine	0.3056
p.E901D	TCGA-AP-A1DV	UCEC	TCGA	LIPFTE	LIG_APCC_ABBA_1	896:901	Mutation altering degron motif	0.5647
p.E901D	DO43186	UCEC	ICGC	LIPFTE	LIG_APCC_ABBA_1	896:901	Mutation altering degron motif	0.5647
p.K1548E	TCGA-AX-A06F	UCEC	TCGA	SRPQLESLS	DEG_APCC_DBOX_1	1537:1545	Mutation substituting flanking lysine	0.3611
p.K1548E	DO41752	UCEC	ICGC	SRPQLESLS	DEG_APCC_DBOX_1	1537:1545	Mutation substituting flanking lysine	0.3611
p.S1545N	TCGA-BH-A0HF	BRCA	TCGA	SRPQLESLS	DEG_APCC_DBOX_1	1537:1545	Mutation altering degron motif	0.5958
p.S1545N	DO1749	BRCA	ICGC	SRPQLESLS	DEG_APCC_DBOX_1	1537:1545	Mutation altering degron motif	0.5958
p.D1527Y	TCGA-BK-A6W3	UCEC	TCGA	SRPQLESLS	DEG_APCC_DBOX_1	1537:1545	Mutation rewiring degron network	0.0556
p.D1527Y	DO7801	COAD	ICGC	SRPQLESLS	DEG_APCC_DBOX_1	1537:1545	Mutation rewiring degron network	0.0556
p.D1527Y	DO50076	UCEC	ICGC	SRPQLESLS	DEG_APCC_DBOX_1	1537:1545	Mutation rewiring degron network	0.0556
p.E1476D	TCGA-CA-6717	COAD	TCGA	PDSSS	DEG_SPOP_SBC_1	1485:1489	Mutation rewiring degron network	0.0833
p.E1476D	DO8264	COAD	ICGC	PDSSS	DEG_SPOP_SBC_1	1485:1489	Mutation rewiring degron network	0.0833
p.G893C	TCGA-D3-A1QA	SKCM	TCGA	LIPFTE	LIG_APCC_ABBA_1	896:901	Mutation rewiring degron network	0.25
p.G893C	DO231672	LINC	ICGC	LIPFTE	LIG_APCC_ABBA_1	896:901	Mutation rewiring degron network	0.25
p.G893C	DO47469	SKCM	ICGC	LIPFTE	LIG_APCC_ABBA_1	896:901	Mutation rewiring degron network	0.25
p.M1477L	TCGA-D7-6525	STAD	TCGA	PDSSS	DEG_SPOP_SBC_1	1485:1489	Mutation rewiring degron network	0.1111
p.M1477L	DO38783	STAD	ICGC	PDSSS	DEG_SPOP_SBC_1	1485:1489	Mutation rewiring degron network	0.1111
p.T1241N	TCGA-DA-A1HW	SKCM	TCGA	VSKTPKKT	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.7055
p.T1241N	DO38129	SKCM	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.7055
p.R1538Q	TCGA-DU-7013	LGG	TCGA	SRPQLESLS	DEG_APCC_DBOX_1	1537:1545	Mutation altering degron motif	0.7329
p.R1538Q	DO22217	LGG	ICGC	SRPQLESLS	DEG_APCC_DBOX_1	1537:1545	Mutation altering degron motif	0.7329
p.R1538Q	SIDM00363	Acute Myeloid Leukemia	GDSC	SRPQLESLS	DEG_APCC_DBOX_1	1537:1545	Mutation altering degron motif	0.7329
p.R1538Q	ACH-000770	Leukemia	CCLE	SRPQLESLS	DEG_APCC_DBOX_1	1537:1545	Mutation altering degron motif	0.7329
p.R1538Q	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	SRPQLESLS	DEG_APCC_DBOX_1	1537:1545	Mutation altering degron motif	0.7329
p.K909N	TCGA-EO-A3AY	UCEC	TCGA	LIPFTE	LIG_APCC_ABBA_1	896:901	Mutation substituting flanking lysine	0.2222
p.K909N	DO43202	UCEC	ICGC	LIPFTE	LIG_APCC_ABBA_1	896:901	Mutation substituting flanking lysine	0.2222
p.T2490N	DO44216	BRCA	ICGC	DSGFAKT	DEG_SCF_TRCP1_1	2496:2502	Mutation rewiring degron network	0.1667
p.C1554G	DO222492	COCA	ICGC	SRPQLESLS	DEG_APCC_DBOX_1	1537:1545	Mutation rewiring degron network	0.0833
p.C1554G	SIDM01020	Plasma Cell Myeloma	GDSC	SRPQLESLS	DEG_APCC_DBOX_1	1537:1545	Mutation rewiring degron network	0.0833
p.C1554G	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	SRPQLESLS	DEG_APCC_DBOX_1	1537:1545	Mutation rewiring degron network	0.0833
p.C1554G	SIDM00928	Breast Carcinoma	GDSC	SRPQLESLS	DEG_APCC_DBOX_1	1537:1545	Mutation rewiring degron network	0.0833
p.C1554G	SIDM01114	Non-Cancerous	GDSC	SRPQLESLS	DEG_APCC_DBOX_1	1537:1545	Mutation rewiring degron network	0.0833
p.C1554G	SIDM00100	Mesothelioma	GDSC	SRPQLESLS	DEG_APCC_DBOX_1	1537:1545	Mutation rewiring degron network	0.0833
p.G1252R	DO229010	COCA	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	1238:1245	Mutation rewiring degron network	0.1389
p.G1252R	DO229013	COCA	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	1238:1245	Mutation rewiring degron network	0.1389
p.G1252R	DO229005	COCA	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	1238:1245	Mutation rewiring degron network	0.1389
p.G1252R	DO229346	LAML	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	1238:1245	Mutation rewiring degron network	0.1389
p.G1252R	DO229489	LAML	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	1238:1245	Mutation rewiring degron network	0.1389
p.G1252R	DO230659	LAML	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	1238:1245	Mutation rewiring degron network	0.1389
p.G1252R	DO231140	LAML	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	1238:1245	Mutation rewiring degron network	0.1389
p.K1243R	DO234186	ESAD	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	1238:1245	Mutation altering degron motif	0.6126
p.P1485H	DO229028	LICA	ICGC	PDSSS	DEG_SPOP_SBC_1	1485:1489	Mutation altering degron motif	0.7694
p.T1228N	DO229035	LICA	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	1238:1245	Mutation rewiring degron network	0.0556
p.L2509M	DO229041	LICA	ICGC	DSGFAKT	DEG_SCF_TRCP1_1	2496:2502	Mutation rewiring degron network	0.1389
p.S1535F	DO220851	MELA	ICGC	SRPQLESLS	DEG_APCC_DBOX_1	1537:1545	Mutation rewiring degron network	0.2778
p.M2512I	DO28923	OV	ICGC	DSGFAKT	DEG_SCF_TRCP1_1	2496:2502	Mutation rewiring degron network	0.0556
p.D1553N	DO232761	PBCA	ICGC	SRPQLESLS	DEG_APCC_DBOX_1	1537:1545	Mutation rewiring degron network	0.1111
p.G893A	DO232933	PEME	ICGC	LIPFTE	LIG_APCC_ABBA_1	896:901	Mutation rewiring degron network	0.25
p.L1496F	DO46850	RECA	ICGC	PDSSS	DEG_SPOP_SBC_1	1485:1489	Mutation rewiring degron network	0.1389
p.D2505H	DO223272	SARC	ICGC	DSGFAKT	DEG_SCF_TRCP1_1	2496:2502	Mutation rewiring degron network	0.25
p.P898S	DO229456	SKCA	ICGC	LIPFTE	LIG_APCC_ABBA_1	896:901	Mutation altering degron motif	0.6752
p.K2501N	SIDM00193	Colorectal Carcinoma	GDSC	DSGFAKT	DEG_SCF_TRCP1_1	2496:2502	Mutation altering degron motif	0.5806
p.K2501N	ACH-000991	Colon/Colorectal Cancer	CCLE	DSGFAKT	DEG_SCF_TRCP1_1	2496:2502	Mutation altering degron motif	0.5806
p.K2501N	SNU-81	large intestine	COSMIC	DSGFAKT	DEG_SCF_TRCP1_1	2496:2502	Mutation altering degron motif	0.5806
p.S2497N	SIDM00842	Colorectal Carcinoma	GDSC	DSGFAKT	DEG_SCF_TRCP1_1	2496:2502	Mutation altering degron motif	0.7069
p.S2497N	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	DSGFAKT	DEG_SCF_TRCP1_1	2496:2502	Mutation altering degron motif	0.7069
p.V891A	SIDM00493	Other Solid Cancers	GDSC	LIPFTE	LIG_APCC_ABBA_1	896:901	Mutation rewiring degron network	0.1944
p.A1479V	SIDM00467	Acute Myeloid Leukemia	GDSC	PDSSS	DEG_SPOP_SBC_1	1485:1489	Mutation rewiring degron network	0.1667
p.A1479V	ACH-002299	Leukemia	CCLE	PDSSS	DEG_SPOP_SBC_1	1485:1489	Mutation rewiring degron network	0.1667
p.A1479V	QIMR-WIL	haematopoietic and lymphoid tissue	COSMIC	PDSSS	DEG_SPOP_SBC_1	1485:1489	Mutation rewiring degron network	0.1667
p.K908N	SIDM01588	Endometrial Carcinoma	GDSC	LIPFTE	LIG_APCC_ABBA_1	896:901	Mutation blocking ubiquitination signal	0.5833
p.K908N	ACH-000993	Endometrial/Uterine Cancer	CCLE	LIPFTE	LIG_APCC_ABBA_1	896:901	Mutation blocking ubiquitination signal	0.5833

Kaplan plot for SETX in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SETX

UniProt ID: Q7Z333

Entrez ID: 23064

Protein name: Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SETX in