DegronMD

Uniprot ID: Q7Z333

Source protein: Probable helicase senataxin

Source gene: SETX

Class: DEG_SCF_FBW7_1

Location: 1238:1245

E3 ligase: FBXW7

DEGRON score: 0.9957

ASA_SCORE: 110.875

COIL: 0.9245

CONS_SCORE: 0.281

DSS_SCORE: 0.6401

HELIX: 0.0185

FCONS_SCORE: 1.1247

RIG_SCORE: 0.6707

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1233M	TCGA-05-4389	LUAD	TCGA	VSKTPKKT	DEG_SCF_FBW7_1	0.1944
p.I1233M	DO24307	LUAD	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	0.1944
p.Q1253H	TCGA-06-5416	GBM	TCGA	VSKTPKKT	DEG_SCF_FBW7_1	0.1111
p.Q1253H	DO10880	GBM	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	0.1111
p.E1231K	TCGA-93-8067	LUAD	TCGA	VSKTPKKT	DEG_SCF_FBW7_1	0.1389
p.E1231K	DO25113	LUAD	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	0.1389
p.K1250N	TCGA-AG-A002	READ	TCGA	VSKTPKKT	DEG_SCF_FBW7_1	0.3056
p.T1241N	TCGA-DA-A1HW	SKCM	TCGA	VSKTPKKT	DEG_SCF_FBW7_1	0.7055
p.T1241N	DO38129	SKCM	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	0.7055
p.G1252R	DO229010	COCA	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	0.1389
p.G1252R	DO229013	COCA	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	0.1389
p.G1252R	DO229005	COCA	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	0.1389
p.G1252R	DO229346	LAML	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	0.1389
p.G1252R	DO229489	LAML	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	0.1389
p.G1252R	DO230659	LAML	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	0.1389
p.G1252R	DO231140	LAML	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	0.1389
p.K1243R	DO234186	ESAD	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	0.6126
p.T1228N	DO229035	LICA	ICGC	VSKTPKKT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z333	Probable helicase senataxin	DEG_SCF_FBW7_1	1238:1245	VSKTPKKT	FBXW7	0.9957	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons